{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:29:53Z","timestamp":1790800193760,"version":"4.1.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Women have a higher rate of adverse events after mitral valve surgery. We sought to evaluate whether outcomes after transcatheter edge-to-edge repair intervention by sex have similar trends to mitral valve surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The primary outcome was 1-year major adverse events defined as a composite of all-cause mortality, stroke, and any bleeding in the overall study cohort. Patients who underwent transcatheter edge-to-edge repair for mitral regurgitation with the MitraClip system in the Society of Thoracic Surgery\/American College of Cardiology Transcatheter Valve Therapy registry were evaluated. Linked administrative claims from the Centers for Medicare and Medicaid Services were used to evaluate 1-year clinical outcomes. Associations between sex and outcomes were evaluated using a multivariable logistic regression model for in-hospital outcomes and Cox model for 1-year outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              From November 2013 to March 2017, 5295 patients, 47.6% (n=2523) of whom were female, underwent transcatheter edge-to-edge repair. Females were less likely to have &gt;1 clip implanted (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and had a lower adjusted odds ratio of device success (adjusted odds ratio, 0.78 [95% CI, 0.67\u20130.90]), driven by lower odds of residual mitral gradient &lt;5 mm\u2009Hg (adjusted odds ratio, 0.54 [CI, 0.46\u20130.63]) when compared with males. At 1-year follow-up, the primary outcome did not differ by sex. Female sex was associated with lower adjusted 1-year risk of all-cause mortality (adjusted hazard ratio, 0.80 [CI, 0.68\u20130.94]), but the adjusted 1-year risk of stroke and any bleeding did not differ by sex.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>No difference in composite outcome of all-cause mortality, stroke, and any bleeding was observed between females and males. Adjusted 1-year all-cause mortality was lower in females compared with males.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009374","type":"journal-article","created":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T19:00:28Z","timestamp":1637089228000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Sex-Based Differences in Outcomes With Percutaneous Transcatheter Repair of Mitral Regurgitation With the MitraClip System: Transcatheter Valve Therapy Registry From 2011 to 2017"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6266-9637","authenticated-orcid":true,"given":"Pedro A.","family":"Villablanca","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-2957","authenticated-orcid":true,"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.V., A.S., D.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-9025","authenticated-orcid":true,"given":"Amanda","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.V., A.S., D.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dadi","family":"Dai","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (S.V., A.S., D.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-714X","authenticated-orcid":true,"given":"Chak-yu","family":"So","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-6504","authenticated-orcid":true,"given":"Marvin H.","family":"Eng","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dee Dee","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberio M.","family":"Frisoli","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-4012","authenticated-orcid":true,"given":"James C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guson","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiology, Center for Structural Heart Disease, Henry Ford Hospital, Detroit, MI (P.A.V., C.-y.S., M.H.E., D.D.W., T.M.F., J.C.L., G.K., A.L., W.W.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Szerlip","sequence":"additional","affiliation":[{"name":"Baylor Scott and White Health, Plano, TX (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homam","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine (H.I., C.S., M.R.W., B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-8889","authenticated-orcid":true,"given":"Cezar","family":"Staniloae","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman 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