{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:40:27Z","timestamp":1770352827203,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The folded valve is a manual shortening of the Melody device, which has been validated as a valuable therapeutic option for the management of dysfunctional right ventricular outflow tracts needing a short valved stent. In this article, we aimed to evaluate, in a multicenter cohort, the mid-term outcomes of patients in whom a percutaneous pulmonary valve implantation was performed using the folded valve technique.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>A 2012 to 2018 retrospective multicenter study was performed in 7 European institutions. All patients who benefit from percutaneous pulmonary valve implantation with a folded Melody valve were included.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              A total of 49 patients (median age, 19 years [range 4\u201356], 63% male) were included. The primary percutaneous pulmonary valve implantation indication was right ventricular outflow tract stenosis (n=19; 39%), patched native right ventricular outflow tracts were the most common substrate (n=15; 31%). The folded technique was mostly used in short right ventricular outflow tracts (n=28; 57%). Procedural success was 100%. After a median follow-up of 28 months (range, 4\u201380), folded Melody valve function was comparable to the immediate postimplantation period (mean transvalvular peak velocity=2.6\u00b10.6 versus 2.4\u00b10.6 m\/s,\n              <jats:italic>P<\/jats:italic>\n              &gt;0.1; only 2 patients had mild pulmonary regurgitation). Incidence rate of valve-related reinterventions was 2.1% per person per year (95% CI, 0.1%\u20133.9%). The probability of survival without valve-related reinterventions at 36 months was 90% (95% CI, 76%\u2013100%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The folded Melody valve is a safe technique with favorable mid-term outcomes up to 6.5 years after implantation, comparable with the usual Melody valve implantation procedure. Complications and reinterventions rates were low, making this technique relevant in selected patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009707","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T09:00:31Z","timestamp":1615971631000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Mid-Term Outcomes Following Percutaneous Pulmonary Valve Implantation Using the \u201cFolded Melody Valve\u201d Technique"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4968-8526","authenticated-orcid":true,"given":"Zakaria","family":"Jalal","sequence":"first","affiliation":[{"name":"Bordeaux University Hospital (CHU), Department of Pediatric and Adult Congenital Cardiology, Pessac, France (Z.J., E.V., J.-B.T.)."},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Universit\u00e9, Pessac-Bordeaux, France (Z.J., E.V., X.P., J.-B.T.)."},{"name":"INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, France (Z.J., E.V., X.P., J.-B.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9720-9008","authenticated-orcid":true,"given":"Est\u00edbaliz","family":"Valdeolmillos","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Department of Pediatric and Adult Congenital Cardiology, Pessac, France (Z.J., E.V., J.-B.T.)."},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Universit\u00e9, Pessac-Bordeaux, France (Z.J., E.V., X.P., J.-B.T.)."},{"name":"INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, France (Z.J., E.V., X.P., J.-B.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Malekzadeh-Milani","sequence":"additional","affiliation":[{"name":"Department of Congenital and Pediatric Cardiology, Centre de Reference Malformations Cardiaques Congenitales Complexes\u2014M3C, Necker Hospital for Sick Children, Assistance Publique des H\u00f4pitaux de Paris, Pediatric Cardiology, France (S.M.-M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Eicken","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Germany (A.E., S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6239-8160","authenticated-orcid":true,"given":"Stanimir","family":"Georgiev","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Congenital Heart Disease, German Heart Center Munich at the TU Munich, Germany (A.E., S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hofbeck","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Children\u2019s Hospital, Tuebingen, Germany (M.H., L.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludger","family":"Sieverding","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Children\u2019s Hospital, Tuebingen, Germany (M.H., L.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-5922","authenticated-orcid":true,"given":"Marc","family":"Gewillig","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, University Hospitals Leuven, Belgium (M.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-2760","authenticated-orcid":true,"given":"Caroline","family":"Ovaert","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology and Congenital Heart Disease, AP-HM, Timone enfants, Hopital de la Timone, Provence-Alpes-C\u00f4te d\u2019Azur, France (C.O.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Bouvaist","sequence":"additional","affiliation":[{"name":"Cardiology Department, CHU Grenoble, France (H.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Pillois","sequence":"additional","affiliation":[{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Universit\u00e9, Pessac-Bordeaux, France (Z.J., E.V., X.P., J.-B.T.)."},{"name":"INSERM, Centre de recherche Cardio-Thoracique de Bordeaux, U1045, France (Z.J., E.V., X.P., J.-B.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Benoit","family":"Thambo","sequence":"additional","affiliation":[{"name":"Bordeaux University Hospital (CHU), Department of Pediatric and Adult Congenital Cardiology, Pessac, France (Z.J., E.V., J.-B.T.)."},{"name":"IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux 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