{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:39:10Z","timestamp":1753882750594,"version":"3.41.2"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Uncertainty exists over whether stents commonly used for percutaneous coronary intervention have comparable short- and long-term safety. The objective of this study was to determine the outcomes of patients treated with bioabsorbable polymer everolimus-eluting (BP-EES; Synergy, Boston Scientific), durable polymer everolimus-eluting (DP-EES; XIENCE, Abbott Vascular), or durable polymer zotarolimus-eluting (DP-ZES; Resolute, Medtronic) stents in routine clinical practice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>All percutaneous coronary intervention cases from 48 hospitals performed after the introduction of the BP-EES stent in 2015 until the first quarter of 2018 were included. Propensity-matched multivariable analysis was used to adjust for differences in baseline characteristics and procedural variables. After matching, we performed pair-wise comparisons between DP-EES and BP-EES, DP-EES and DP-ZES, and BP-EES and DP-ZES for in-hospital postpercutaneous coronary intervention outcomes. We also evaluated 2-year postdischarge mortality in a subset of patients who could be matched to Medicare data.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              During the study period, 53\u2009724 percutaneous coronary intervention cases were performed. A total of 59% of patients were treated with DP-EES stents, 14% with BP-EES stents, and 27% with DP-ZES stents. Although baseline characteristics of patients differed between stent types, these differences were attenuated after matching. In the matched cohort, there was no difference in in-hospital mortality, stent thrombosis, or postprocedural stroke (a falsification end point) between BP-EES, DP-EES, and DP-ZES. After matching, there was no difference in 2-year postdischarge mortality (DP-EES versus BP-EES hazard ratio 0.91,\n              <jats:italic>P<\/jats:italic>\n              =0.50; DP-EES versus DP-ZES hazard ratio 1.03,\n              <jats:italic>P<\/jats:italic>\n              =0.77; BP-EES versus DP-ZES hazard ratio 1.20,\n              <jats:italic>P<\/jats:italic>\n              =0.29).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Our data suggest similar risk-adjusted in-hospital outcomes among drug-eluting stent platforms commonly used in clinical practice. The absence of a difference in 2-year mortality between BP-EES, DP-EES, and DP-ZES suggests that stent choice decisions could be made based on other factors, including durability, availability, and cost.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009850","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T10:00:16Z","timestamp":1614247216000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Safety of Bioabsorbable Polymer Everolimus-Eluting, Durable Polymer Everolimus-Eluting, and Durable Polymer Zotarolimus-Eluting Stents in Contemporary Clinical Practice"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-3085","authenticated-orcid":true,"given":"Nadia R.","family":"Sutton","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (N.R.S., M.S., D.S., H.S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Seth","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (N.R.S., M.S., D.S., H.S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan D.","family":"Madder","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Spectrum Health, Grand Rapids, MI (R.D.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devraj","family":"Sukul","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (N.R.S., M.S., D.S., H.S.G.)."},{"name":"Department of Medicine, Section of Cardiology, Veterans Affairs Medical Center, Ann Arbor, MI (D.S., H.S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon R.","family":"Dixon","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Beaumont Hospital, Royal Oak, MI (S.R.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis A.","family":"Cannon","sequence":"additional","affiliation":[{"name":"Cardiac and Vascular Research Center of Northern Michigan, Petoskey (L.A.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitinder S.","family":"Gurm","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor (N.R.S., M.S., D.S., H.S.G.)."},{"name":"Department of Medicine, Section of Cardiology, Veterans Affairs Medical Center, Ann Arbor, MI (D.S., 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