{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:37:26Z","timestamp":1783024646337,"version":"3.54.6"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Physiological assessment with pressure wire pullback can characterize coronary artery disease (CAD) with a focal or diffuse pattern. However, the clinical relevance of this distinction is unknown. We use data from the ORBITA trial (Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina) to test if the pattern of CAD predicts the placebo-controlled efficacy of percutaneous coronary intervention (PCI) on stress echocardiography ischemia and symptom end points.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>One hundred sixty-four patients in ORBITA underwent blinded instantaneous wave-free ratio (iFR) pullback assessment before randomization. Focal disease was defined as a \u22650.03 iFR unit drop within 15 mm, rather than over a longer distance. Analyses were performed using regression modeling.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In the PCI arm (n=85), 48 were focal and 37 were diffuse. In the placebo arm (n=79), 35 were focal and 44 were diffuse. Focal stenoses were associated with significantly lower fractional flow reserve (FFR) and iFR values than diffusely diseased vessels (mean FFR and iFR, focal 0.60\u00b10.15 and 0.65\u00b10.24, diffuse 0.78\u00b10.10 and 0.88\u00b10.08, respectively,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001). With adjustment for this difference, PCI for focal stenoses resulted in significantly greater reduction in stress echo ischemia than PCI for diffuse disease (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05). The effect of PCI on between-arm pre-randomization adjusted exercise time was 9.32 seconds (95% CI, \u221217.1 to 35.7 seconds;\n              <jats:italic>P<\/jats:italic>\n              =0.487). When stratified for pattern of disease, there was no detectable difference between focal and diffuse CAD (\n              <jats:italic>P<\/jats:italic>\n              interaction=0.700). PCI improved Seattle Angina Questionnaire angina frequency score and freedom from angina more than placebo (\n              <jats:italic>P<\/jats:italic>\n              =0.034;\n              <jats:italic>P<\/jats:italic>\n              =0.0035). However, there was no evidence of interaction between the physiological pattern of CAD and these effects (\n              <jats:italic>P<\/jats:italic>\n              interaction=0.436;\n              <jats:italic>P<\/jats:italic>\n              interaction=0.908).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>PCI achieved significantly greater reduction of stress echocardiography ischemia in focal compared with diffuse CAD. However, for symptom end points, no such difference was observed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique Identifier: NCT02062593.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.009891","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T09:00:40Z","timestamp":1627981240000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Placebo-Controlled Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Patterns of Stable Coronary Artery Disease"],"prefix":"10.1161","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct02062593","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Christopher A.","family":"Rajkumar","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-0867","authenticated-orcid":true,"given":"Matthew","family":"Shun-Shin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Seligman","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousif","family":"Ahmad","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Columbia University Medical Centre, New York\u2013Presbyterian Hospital (Y.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Warisawa","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"St. Marianna University School of Medicine, Yokohama, Japan (T.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Cook","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Basildon, United Kingdom (C.M.C., T.R.K., J.R.D., K.H.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Howard","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sashiananthan","family":"Ganesananthan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Amarin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Khan","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-1915","authenticated-orcid":true,"given":"Ayesha","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Sheffield, United Kingdom (A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Nowbar","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Foley","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Assomull","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall G.","family":"Keenan","sequence":"additional","affiliation":[{"name":"West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom (N.G.K., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joban","family":"Sehmi","sequence":"additional","affiliation":[{"name":"West Hertfordshire Hospitals NHS Trust, Watford, United Kingdom (N.G.K., J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-7994","authenticated-orcid":true,"given":"Thomas R.","family":"Keeble","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Basildon, United Kingdom (C.M.C., T.R.K., J.R.D., K.H.T.)."},{"name":"Anglia Ruskin School of Medicine, Chelmsford, Essex, United Kingdom (T.R.K., J.R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Davies","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Basildon, United Kingdom (C.M.C., T.R.K., J.R.D., K.H.T.)."},{"name":"Anglia Ruskin School of Medicine, Chelmsford, Essex, United Kingdom (T.R.K., J.R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kare H.","family":"Tang","sequence":"additional","affiliation":[{"name":"Essex Cardiothoracic Centre, Basildon, United Kingdom (C.M.C., T.R.K., J.R.D., K.H.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Gerber","sequence":"additional","affiliation":[{"name":"East Sussex Healthcare NHS Trust, Hastings, United Kingdom (R.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3157-0335","authenticated-orcid":true,"given":"Graham","family":"Cole","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"O\u2019Kane","sequence":"additional","affiliation":[{"name":"Royal Bournemouth and Christchurch NHS Trust, Bournemouth, United Kingdom (P.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S.P.","family":"Sharp","sequence":"additional","affiliation":[{"name":"University Hospital of Wales, Cardiff, United Kingdom (A.S.P.S.)."},{"name":"University of Exeter, United Kingdom (A.S.P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi","family":"Khamis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gajen","family":"Kanaganayagam","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Petraco","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3968-2750","authenticated-orcid":true,"given":"Neil","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-5614","authenticated-orcid":true,"given":"Iqbal S.","family":"Malik","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9146-1037","authenticated-orcid":true,"given":"Sukhjinder","family":"Nijjer","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayan","family":"Sen","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3410-0814","authenticated-orcid":true,"given":"Darrel P.","family":"Francis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-5532","authenticated-orcid":true,"given":"Rasha","family":"Al-Lamee","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London, United Kingdom (C.A.R., M.S.-S., H.S., Y.A., T.W., J.P.H., S.G., L.A., C.K., A.N., M.F., R.A., G.C., R.K., R.P., N.R., S.N., S.S., D.P.F., R.A.-L.)."},{"name":"Imperial College Healthcare NHS Trust, London, United Kingdom (C.A.R., M.S.-S., H.S., J.P.H., A.N., M.F., R.A., G.C., R.K., G.K., R.P., N.R., I.S.M., S.N., S.S., D.P.F., R.A.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.103.24.2928"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.06.015"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.005"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32714-9"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.033801"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.05.054"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042918"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0895-4356(01)00352-3"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072771"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.7433"},{"key":"e_1_3_5_15_2","volume-title":"R: A Language and Environment for Statistical Computing","author":"Team RDC","year":"2010","unstructured":"Team RDC. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, 2010."},{"key":"e_1_3_5_16_2","article-title":"rms: Regression Modeling Strategies.","author":"Harrell F","unstructured":"Harrell, F. rms: Regression Modeling Strategies. R package version 3.4.3.2018.","journal-title":"R package version 3.4.3.2018"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"e_1_3_5_18_2","unstructured":"Nguyen J Matsumura M Maehara A Jeremias A. Physiological assessment after PCI: the new routine? Lessons from DEFINE PCI. 2019. American College of Cardiology. https:\/\/www.acc.org\/latest-in-cardiology\/articles\/2019\/09\/23\/08\/14\/physiological-assessment-after-pci. Accessed April 1 2020."},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1915922"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.15.1840"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00635"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13764"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.120.009891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:27:21Z","timestamp":1715567241000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.120.009891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":21,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.120.009891"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.120.009891","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"2020-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e009891"}}