{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:04:17Z","timestamp":1786496657660,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Reported rates of acute kidney injury (AKI) after transcatheter aortic valve replacement in small observational studies vary widely.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Patients who underwent transcatheter aortic valve replacement in the United States between January 1, 2016 and June 30, 2018, were included. Patients without reported baseline or peak creatinine values and those who were previously on hemodialysis were excluded. AKI was defined using AKI Network criteria from stages 0 to 3. Logistic regression was used to assess patient and clinical factors associated with incident in-hospital AKI. Among patients with available data from the Center for Medicare and Medicaid Services administrative files, we compared 1-year mortality among patients with and without AKI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Of 107\u2009814 study patients, 11\u2009566 (10.7%) experienced postprocedural AKI. Among patients who developed AKI, 10\u2009220 (9.5%) experienced stage 1 AKI, 134 (0.1%) stage 2 AKI, and 1212 (1.1%) stage 3 AKI. Race, baseline comorbidities, clinical presentation, and procedural factors were associated with the development of stage 3 AKI. In Center for Medicare and Medicaid Services\u2013linked analyses of 62\u2009757 (58.2%) patients, those with AKI had higher adjusted hazard ratio for mortality at 1 year compared with patients who did not experience AKI (stage 1 AKI: adjusted hazard ratio, 2.7 [95% CI, 2.5\u20132.8],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; stage 2 AKI: adjusted hazard ratio, 10.4 [95% CI, 7.0\u201315.4],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; stage 3 AKI: adjusted hazard ratio, 7.0 [95% CI, 6.0\u20138.2],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Using data from the Society of Thoracic Surgeons\/American College of Cardiology National Cardiovascular Data Registry Transcatheter Valve Therapy Registry registry, we found that AKI is common after transcatheter aortic valve replacement, with over 10% of patients developing postprocedure AKI. Patients who developed stage 3 AKI had 7\u00d7 higher adjusted 1-year mortality compared with patients who did not develop AKI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.120.010032","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T18:26:59Z","timestamp":1618943219000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Incidence, Predictors, and Outcomes of Acute Kidney Injury in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-097X","authenticated-orcid":true,"given":"Howard M.","family":"Julien","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0808-9025","authenticated-orcid":true,"given":"Amanda","family":"Stebbins","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (A.S., S.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1599-2957","authenticated-orcid":true,"given":"Sreekanth","family":"Vemulapalli","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, NC (A.S., S.V.)."},{"name":"Duke University Health System, Duke Heart Center, Division of Cardiology, Durham, NC (S.V., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-6423","authenticated-orcid":true,"given":"Ashwin S.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Penn Cardiovascular Outcomes, Quality, &amp; Evaluative Research Center (A.S.N., P.G., N.D.D., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Perelman School of Medicine and The Leonard Davis Institute of Health Economics (A.S.N., N.D.E., P.G., N.D.D.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwamaka D.","family":"Eneanya","sequence":"additional","affiliation":[{"name":"Renal-Electrolyte and Hypertension Division (N.D.E.), Palliative and Advanced Illness Research Center (N.D.E.), University of Pennsylvania, Philadelphia, PA."},{"name":"Perelman School of Medicine and The Leonard Davis Institute of Health Economics (A.S.N., N.D.E., P.G., N.D.D.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7374-4292","authenticated-orcid":true,"given":"Peter","family":"Groeneveld","sequence":"additional","affiliation":[{"name":"Penn Cardiovascular Outcomes, Quality, &amp; Evaluative Research Center (A.S.N., P.G., N.D.D., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Division of General Internal Medicine (P.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Perelman School of Medicine and The Leonard Davis Institute of Health Economics (A.S.N., N.D.E., P.G., N.D.D.), University of Pennsylvania, Philadelphia, PA."},{"name":"Center for Health Equity Research and Promotion, Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Fiorilli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3322-9568","authenticated-orcid":true,"given":"Howard C.","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson Y.","family":"Szeto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimesh D.","family":"Desai","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Penn Cardiovascular Outcomes, Quality, &amp; Evaluative Research Center (A.S.N., P.G., N.D.D., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Perelman School of Medicine and The Leonard Davis Institute of Health Economics (A.S.N., N.D.E., P.G., N.D.D.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif","family":"Anwaruddin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-9114","authenticated-orcid":true,"given":"Amit","family":"Vora","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center-Pinnacle, Wormleysburg, PA (A.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-8001","authenticated-orcid":true,"given":"Binita","family":"Shah","sequence":"additional","affiliation":[{"name":"NYU School of Medicine (B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian G.","family":"Ng","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York, New York (V.G.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4321-4538","authenticated-orcid":true,"given":"Dharam J.","family":"Kumbhani","sequence":"additional","affiliation":[{"name":"Division of Cardiology, UT Southwestern Medical Center, Dallas (D.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8076-0098","authenticated-orcid":true,"given":"Jay","family":"Giri","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (H.M.J., A.S.N., P.N.F., H.C.H., W.Y.S., N.D.D., S.A., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Penn Cardiovascular Outcomes, Quality, &amp; Evaluative Research Center (A.S.N., P.G., N.D.D., J.G.), University of Pennsylvania, Philadelphia, PA."},{"name":"Duke University Health System, Duke Heart Center, Division of Cardiology, Durham, NC (S.V., J.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001380"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.01.019"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.10.007"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.03.008"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21619"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20316"},{"key":"e_1_3_5_8_2","first-page":"18","article-title":"Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention.","volume":"15","author":"Iakovou I","year":"2003","unstructured":"Iakovou, I, Dangas, G, Mehran, R, Lansky, AJ, Ashby, DT, Fahy, M, Mintz, GS, Kent, KM, Pichard, AD, Satler, LF, et al. Impact of gender on the incidence and outcome of contrast-induced nephropathy after percutaneous coronary intervention. J Invasive Cardiol. 2003;15:18\u201322.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002212"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.07.043"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.218677"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1161-5"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.05.011"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2015.1002467"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.10.029"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.09.090"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.060"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfs160"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrsc.2015.11.004"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.015"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2015.0326"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I9A164"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.4812"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.08.89"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026656"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.03.008"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.12.019"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1244072"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282043"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3316"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.03.007"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002703"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00177.x"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006367"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.17.19340"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.120.010032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:26:27Z","timestamp":1715567187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.120.010032"}},"subtitle":["Insights From the Society of Thoracic Surgeons\/American College of Cardiology National Cardiovascular Data Registry\u2013Transcatheter Valve Therapy Registry"],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.120.010032"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.120.010032","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e010032"}}