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Myocardial reperfusion injury is the result of several complex nonlinear phenomena, and for a therapy to be effective, it should act on multiple targets involved in this injury. In this regard, hypothermia remains a promising treatment despite a number of negative randomized controlled trials in humans with acute myocardial infarction so far. To turn the tide for hypothermia in patients with acute myocardial infarction, sophisticated solutions for important limitations of systemic hypothermia should continue to be developed. In this review, we provide a comprehensive overview of the pathophysiology and clinical expression of myocardial reperfusion injury and discuss the current status and possible future of hypothermia for cardioprotection in patients with acute myocardial infarction.<\/jats:p>","DOI":"10.1161\/circinterventions.120.010326","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T09:00:11Z","timestamp":1626426011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Hypothermia for Reduction of Myocardial Reperfusion Injury in Acute Myocardial Infarction: Closing the Translational Gap"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-0796","authenticated-orcid":true,"given":"Mohamed","family":"El Farissi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle C.J.","family":"Keulards","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-4901","authenticated-orcid":true,"given":"Jo M.","family":"Zelis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"van \u2019t Veer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik M.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico H.J.","family":"Pijls","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8510-8648","authenticated-orcid":true,"given":"Luuk C.","family":"Otterspoor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, the Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742cf6"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.069"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071667"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.086"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310519"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)02567-6"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.02.049"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.957902"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.027"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001965"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00279"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2020.0018"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht090"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.18.1848"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-6-200103200-00009"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)91295-f"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(83)90274-0"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.037"},{"key":"e_1_3_4_20_2","first-page":"98","article-title":"Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.","volume":"111","author":"Engler RL","year":"1983","unstructured":"Engler, RL, Schmid-Sch\u00f6nbein, GW, Pavelec, RS. 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