{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:24:44Z","timestamp":1793942684321,"version":"4.8.0"},"reference-count":70,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>Mitral transcatheter therapies represent the treatment of choice for all patients deemed unsuitable for cardiac surgery. So far, the largest clinical experience has been limited to percutaneous repair techniques. However, given the complexity and heterogeneity of mitral valve anatomy and pathology, transcatheter mitral valve implantation will widen the mitral valve therapies horizon, toward a patient-tailored approach. Current data about transcatheter mitral valve implantation is still limited and, although some data are promising, there are still some issues to be addressed. This review provides a comprehensive insight into the available devices and describes potential advantages and limitations of transcatheter mitral valve implantation.<\/jats:p>","DOI":"10.1161\/circinterventions.121.010628","type":"journal-article","created":{"date-parts":[[2021,8,19]],"date-time":"2021-08-19T09:00:58Z","timestamp":1629363658000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Transcatheter Mitral Valve Implantation: Current Status and Future Perspectives"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-0135","authenticated-orcid":true,"given":"Giulio","family":"Russo","sequence":"first","affiliation":[{"name":"University of Zurich, Switzerland (G.R., M. Gennari,. M.G., A.P., M.T.)."},{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCSS, Roma, Italy (G.R., D.P.)."},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy (G.R., D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9079-3275","authenticated-orcid":true,"given":"Marco","family":"Gennari","sequence":"additional","affiliation":[{"name":"University of Zurich, Switzerland (G.R., M. Gennari,. M.G., A.P., M.T.)."},{"name":"IRCCS Centro Cardiologico Monzino, Milan, Italy (M. Gennari)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Gavazzoni","sequence":"additional","affiliation":[{"name":"University of Zurich, Switzerland (G.R., M. Gennari,. M.G., A.P., M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Pedicino","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli, IRCSS, Roma, Italy (G.R., D.P.)."},{"name":"Universit\u00e0 Cattolica del Sacro Cuore, Roma, Italy (G.R., D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pozzoli","sequence":"additional","affiliation":[{"name":"University of Zurich, Switzerland (G.R., M. Gennari,. M.G., A.P., M.T.)."},{"name":"Heart Surgery Unit, Cardiocentro Ticino, Lugano, Switzerland (A.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"University of Zurich, Switzerland (G.R., M. Gennari,. M.G., A.P., M.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-1709","authenticated-orcid":true,"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"University Hospital San Raffaele, Milano, Italy (F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.094"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv627"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.015"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa062"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000079169.15862.13"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.02.014"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs005"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049088"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy590"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy725"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312047"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.09.039"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.05.001"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.054"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.08.014"},{"key":"e_1_3_5_20_2","volume-title":"Lecture presented at EuroPCR","author":"Guerrero M","year":"2019","unstructured":"Guerrero, M. 1-year outcome of transcatheter MViV, MViR, and ViMAC: results from the MITRAL trial. Lecture presented at EuroPCR 2019, Paris."},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008425"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013332"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00444"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-01051"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.066"},{"key":"e_1_3_5_26_2","volume-title":"Lecture presented at EuroPCR E-Course","author":"Muller","year":"2020","unstructured":"Muller. Two-years outcome of Tendyne transcatheter mitral valve implantation to treat symptomatic severe mitral regurgitation. Lecture presented at EuroPCR E-Course; 2020."},{"key":"e_1_3_5_27_2","volume-title":"Lecture presented at EuroPCR E-Course","author":"Conradi L","year":"2020","unstructured":"Conradi, L. Transcatheter mitral valve implantation with TIARA: transapical and transseptal design. Lecture presented at EuroPCR E-Course; 2020."},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.061"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV11SWA22"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(20)31741-1"},{"key":"e_1_3_5_31_2","volume-title":"Lecture presented at the Structural Heart Disease Summit","author":"Piazza N","year":"2018","unstructured":"Piazza, N. The HIGHLIFE program: attributes, challenges and clinical data. Lecture presented at the Structural Heart Disease Summit, Chicago; 2018."},{"key":"e_1_3_5_32_2","volume-title":"Lecture presented at the TCT","author":"Makkar R","year":"2018","unstructured":"Makkar, R. SAPIEN M3 transcatheter mitral valve replacement system: 30-day outcomes from the US early feasibility study. Lecture presented at the TCT; 2018."},{"key":"e_1_3_5_33_2","volume-title":"Lecture presented at EuroPCR","author":"Maisano F","year":"2019","unstructured":"Maisano, F. Cardiovalve device attributes, procedure and early results. Lecture presented at EuroPCR; 2019, Paris."},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008003"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.056"},{"key":"e_1_3_5_36_2","unstructured":"Edwards. Edwards Lifesciences website published on May 2015 https:\/\/www.edwards.com\/ns20150519A. (last visited: 03 June 2021)"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.05.032"},{"key":"e_1_3_5_38_2","volume-title":"Paper presented at: Transcatheter Cardiovascular Therapeutics (TCT).","author":"Williams M","year":"2018","unstructured":"Williams, M. Transfemoral TMVR: caisson transcatheter mitral valve replacement. Paper presented at: Transcatheter Cardiovascular Therapeutics (TCT). San Diego, CA; 2018."},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy271"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.01.005"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.12.001"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.033"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.01.035"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.076"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.045"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-20-00454"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.881"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.027"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.08.035"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.01.219"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00834-2"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2003.12.013"},{"key":"e_1_3_5_53_2","first-page":"7E","article-title":"Surgical management of valvular heart disease 2004.","volume":"20","author":"Jamieson WR","year":"2004","unstructured":"Jamieson, WR, Cartier, PC, Allard, M, Boutin, C, Burwash, IG, Butany, J, de Varennes, B, Del Rizzo, D, Dumesnil, JG, Honos, G, et al. Surgical management of valvular heart disease 2004. Can J Cardiol. 2004;20 (suppl E):7E\u2013120E.","journal-title":"Can J Cardiol"},{"key":"e_1_3_5_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.778886"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu307"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.08.013"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000115633.19829.5E"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.07.060"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00598"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.054"},{"key":"e_1_3_5_62_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.96.6.1819"},{"key":"e_1_3_5_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.619239"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1067\/mtc.2001.116557"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1410490"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312808"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.06.047"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000498"},{"key":"e_1_3_5_69_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634436"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.039"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00743"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.121.010628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:26:45Z","timestamp":1715567205000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.121.010628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.121.010628"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.121.010628","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-08-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e010628"}}