{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:56:14Z","timestamp":1790841374387,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with severe tricuspid regurgitation present late and are often ineligible for surgery or transcatheter repair systems. Transfemoral venous implantation of a bicaval valved stent has been proposed as therapeutic option in selected patients. The aim of this study was to summarize the early procedural and clinical outcomes of the novel TRICENTO system for the treatment of patients with symptomatic severe tricuspid regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All consecutive patients treated with the custom-made TRICENTO implant at the participating centers were included in this retrospective multicentre registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 21 high-risk patients (mean age 76\u00b17 years; 67% female) with severe or higher grade tricuspid regurgitation were analyzed. The majority of the patients were in New York Heart Association class III\/IV (95%), had peripheral edema (95%), and previous hospitalization for right heart failure (67%). Technical success was 100%, and there was no case of in-hospital mortality. During follow-up (median 61 days), symptomatic improvement was observed (65% in New York Heart Association class I\/II;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001). Computed tomography revealed asymptomatic fractures of the TRICENTO prosthesis in 3 patients. Cardiac magnetic resonance imaging obtained in 7 patients showed a significant decrease (252\u00b165 mm\n                      <jats:sup>3<\/jats:sup>\n                      at baseline versus 216\u00b158 mm\n                      <jats:sup>3<\/jats:sup>\n                      at follow-up,\n                      <jats:italic>P<\/jats:italic>\n                      =0.006) of right ventricular end-diastolic volume. The overall-survival rate was 76% at 1 year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The present data indicate the feasibility of transfemoral bicaval valved stent implantation for the treatment of severe tricuspid regurgitation. Functional improvement and signs of right ventricular reverse remodeling were observed. Stent fractures did not impair valve function, but require refinement of prosthesis design and careful assessment of eligibility criteria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.121.011302","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T05:00:24Z","timestamp":1646283624000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":52,"title":["Early Clinical Experience With the TRICENTO Bicaval Valved Stent for Treatment of Symptomatic Severe Tricuspid Regurgitation: A Multicenter Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-9756","authenticated-orcid":true,"given":"Mirjam G.","family":"Wild","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inselspital, University Hospital Bern, Switzerland (M.G.W., S.W., F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Hamburg, Germany (E.L., B.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Cruz-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Salamanca, CIBER-CV, IBSAL, Spain (I.C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Amat-Santos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CIBER-CV, University Clinic Hospital Valladolid, Spain (I.A.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7944-9756","authenticated-orcid":true,"given":"Marco","family":"Ancona","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, IRCCS Ospedale San Raffaele, Milano, Italy (M.A., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University of Vienna, Austria (M.A., P.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2802-3533","authenticated-orcid":true,"given":"Niklas F.","family":"Boeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Giessen, Germany (N.F.B., H.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Brandenburg, Bernau, Germany (C.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Carrasco-Chinchilla","sequence":"additional","affiliation":[{"name":"Department of Cardiology, CIBER-CV, University Hospital Malaga, Spain (F.C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-5514","authenticated-orcid":true,"given":"Rodrigo","family":"Estevez-Loureiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Alvaro Cunqueiro, Vigo, Spain (R.E.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kempfert","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, German Heart Center, Berlin, Germany (J.K., A.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"K\u00f6ll","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Hamburg, Germany (E.L., B.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-9459","authenticated-orcid":true,"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, IRCCS Ospedale San Raffaele, Milano, Italy (M.A., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger M.","family":"Nef","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Giessen, Germany (N.F.B., H.M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-0298","authenticated-orcid":true,"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lucerne Cantonal Hospital, Switzerland (S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Unbehaun","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, 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