{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:28:42Z","timestamp":1793831322894,"version":"4.6.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Drug-coated balloons (DCBs) are an established treatment strategy for coronary artery disease. Randomized data on the application of DCBs in patients with an acute coronary syndrome (ACS) are limited. We evaluated the impact of clinical presentation (ACS versus chronic coronary syndrome) on clinical outcomes in patients undergoing DCB or drug-eluting stent (DES) treatment in a prespecified analysis of the BASKET-SMALL 2 trial (Basel Kosten Effektivit\u00e4ts Trial\u2013Drug-Coated Balloons Versus Drug-Eluting Stents in Small Vessel Interventions).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>BASKET-SMALL 2 randomized 758 patients with small vessel coronary artery disease to DCB or DES treatment and followed them for 3 years regarding major adverse cardiac events (cardiac death, nonfatal myocardial infarction, and target vessel revascularization).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Among 758 patients, 214 patients (28.2%) presented with an ACS (15 patients [7%], ST-segment\u2013elevation myocardial infarction; 109 patients [50.9%], non\u2013ST-segment\u2013elevation myocardial infarction; 90 patients [42.1%], unstable angina pectoris). At 1-year follow-up, there was no significant difference in the incidence of the primary end point by randomized treatment in patients with ACS (hazard ratio, 0.50 [95% CI, 0.19\u20131.26] for DCB versus DES) or chronic coronary syndrome (hazard ratio, 1.29 [95% CI, 0.67\u20132.47] for DCB versus DES). There was no significant interaction between clinical presentation and treatment effect (\n              <jats:italic>P<\/jats:italic>\n              for interaction, 0.088). For cardiac death (\n              <jats:italic>P<\/jats:italic>\n              for interaction, 0.049) and nonfatal myocardial infarction (\n              <jats:italic>P<\/jats:italic>\n              for interaction, 0.010), a significant interaction between clinical presentation and treatment was seen at 1 year with lower rates of these secondary end points in patients with ACS treated by DCB. At 3 years, there were similar major adverse cardiac event rates throughout groups without significant interaction between clinical presentation and treatment (\n              <jats:italic>P<\/jats:italic>\n              for interaction, 0.301). All-cause mortality was higher in ACS compared with chronic coronary syndrome; however, there was no difference between DCB and DES irrespective of clinical presentation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In this subgroup analysis of the BASKET-SMALL 2 trial, there was no interaction between indication for percutaneous coronary intervention (acute versus chronic coronary syndrome) and treatment effect of DCB versus DES in patients with small vessel coronary artery disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01574534.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.121.011325","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T10:00:31Z","timestamp":1641808831000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Safety and Efficacy of Drug-Coated Balloons Versus Drug-Eluting Stents in Acute Coronary Syndromes: A Prespecified Analysis of BASKET-SMALL 2"],"prefix":"10.1161","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct01574534","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-7923","authenticated-orcid":true,"given":"Norman","family":"Mangner","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universit\u00e4t Dresden, Germany (N.M., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Farah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Knappschaftskrankenhaus, Klinikum Westfalen, Dortmund, Germany (A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Alexander","family":"Ohlow","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, SRH Wald-Klinikum, Gera, Germany (M.-A.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1319-6738","authenticated-orcid":true,"given":"Sven","family":"M\u00f6bius-Winkler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weilenmann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cantonal Hospital St. Gallen, Switzerland (D.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9915-1815","authenticated-orcid":true,"given":"Jochen","family":"W\u00f6hrle","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Intensive Care, Medizin Campus Bodensee, Friedrichshafen, Germany (J.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Linke","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Cardiology, Herzzentrum Dresden, Technische Universit\u00e4t Dresden, Germany (N.M., A.L.)."},{"name":"Dresden Cardiovascular Research Institute and Core Laboratories GmbH, Germany (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9901-5429","authenticated-orcid":true,"given":"Georg","family":"Stachel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Leipzig, University Hospital, Germany (G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinisa","family":"Markovic","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Ulm, Germany (S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Leibundgut","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cantonal Hospital Baselland, Liestal, Switzerland (G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rickenbacher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (P.R., N.G., C.K., R.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8431","authenticated-orcid":true,"given":"Marco","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University Hospital Basel, University of Basel, Switzerland (M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gilgen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (P.R., N.G., C.K., R.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kaiser","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (P.R., N.G., C.K., R.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-5298","authenticated-orcid":true,"given":"Bruno","family":"Scheller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology and Intensive Care, University of Saarland, Homburg, Germany (B.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1290-5491","authenticated-orcid":true,"given":"Raban V.","family":"Jeger","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, University of Basel, Switzerland (P.R., N.G., C.K., R.V.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the BASKET-SMALL 2 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