{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T22:46:06Z","timestamp":1775947566422,"version":"3.50.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Lifestyle changes and medications are recommended as the first line of treatment for claudication, with revascularization considered for treatment-resistant symptoms, based on patients\u2019 preferences. Real-world evidence comparing health status outcomes of early invasive with noninvasive management strategies is lacking.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>In the international multicenter prospective observational PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories) registry, disease-specific health status was assessed by the Peripheral Artery Questionnaire in patients with new-onset or worsening claudication at presentation and 3, 6, and 12 months later. One-year health status trajectories were compared by early revascularization versus noninvasive management on a propensity-matched sample using hierarchical generalized linear models for repeated measures adjusted for baseline health status.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In a propensity-matched sample of 1000 patients (67.4\u00b19.3 years, 62.8% male, and 82.4% White), 297 (29.7%) underwent early revascularization and 703 (70.3%) were managed noninvasively. Over 1 year of follow-up, patients who underwent early invasive management reported significantly higher health status than patients managed noninvasively (interaction term for time and treatment strategy;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 for all Peripheral Artery Questionnaire domains). The average 1-year change in Peripheral Artery Questionnaire summary scores was 30.8\u00b125.2 in those undergoing early invasive, compared with 16.7\u00b123.4 in those treated noninvasively (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Patients with claudication undergoing early invasive treatment had greater health status improvements over the course of 1 year than those treated noninvasively. These data can be used to support shared decision-making with patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT01419080.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.121.011506","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T18:00:52Z","timestamp":1655834452000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease"],"prefix":"10.1161","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct01419080","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Suveen","family":"Angraal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Missouri Kansas City School of Medicine (S.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-040X","authenticated-orcid":true,"given":"Vittal","family":"Hejjaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saint Luke\u2019s Mid America Heart Institute (V.H., J.A.S.), University of Missouri-Kansas City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (Y.T., K.L.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-6913","authenticated-orcid":true,"given":"Kensey L.","family":"Gosch","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (Y.T., K.L.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2393-0855","authenticated-orcid":true,"given":"Manesh R.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Duke University Medical Center, Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (M.R.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Heyligers","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, St. Elisabeth Hospital, Tilburg, the Netherlands (J.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ochsner Clinical School, University of Queensland, AU, and Ochsner Health, New Orleans, LA (C.J.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Tutein Nolthenius","sequence":"additional","affiliation":[{"name":"Department of (vascular) Surgery, Albert Schweitzer Hospital, Dordrecht, the Netherlands (R.T.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4954-5672","authenticated-orcid":true,"given":"Carlos","family":"Mena-Hurtado","sequence":"additional","affiliation":[{"name":"Vascular Medicine Outcomes Program, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (C.M.-H., K.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-7893","authenticated-orcid":true,"given":"Herbert D.","family":"Aronow","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Lifespan Cardiovascular Institute, Alpert Medical School of Brown University, Providence, RI (H.D.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory L.","family":"Moneta","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Department of Surgery and Knight Cardiovascular Institute, Oregon Health &amp; Science University, Portland (H.D.A., G.L.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fitridge","sequence":"additional","affiliation":[{"name":"Departments of Vascular Surgery, Royal Adelaide and The Queen Elizabeth Hospital, Australia (R.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Soukas","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, The Warren Alpert Medical School of Brown University and Lifespan Cardiovascular Institute, Providence, RI (P.A.S., J.D.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2560-0155","authenticated-orcid":true,"given":"J. Dawn","family":"Abbott","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, The Warren Alpert Medical School of Brown University and Lifespan Cardiovascular Institute, Providence, RI (P.A.S., J.D.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-3163","authenticated-orcid":true,"given":"Eric A.","family":"Secemsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology (E.A.S.), Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA."},{"name":"Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology (E.A.S.), Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-2611","authenticated-orcid":true,"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saint Luke\u2019s Mid America Heart Institute (V.H., J.A.S.), University of Missouri-Kansas City."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6104-6254","authenticated-orcid":true,"given":"Kim G.","family":"Smolderen","sequence":"additional","affiliation":[{"name":"Vascular Medicine Outcomes Program, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT (C.M.-H., K.G.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32409-1"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.06.008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.043"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2006.08.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000470"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.608679"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x03vm483ra"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2017.09.003"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.2002.01055.x"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000052"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011004"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.14851"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.08.001"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.007232"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0006-341x.2000.00118.x"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/03610910902859574"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016900"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.119.005730"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.121.011506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T02:24:16Z","timestamp":1715567056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.121.011506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.121.011506"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.121.011506","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}