{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:42:54Z","timestamp":1776894174321,"version":"3.51.2"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Coronary pressure indices such as fractional flow reserve are the standard for guiding elective revascularization. However, considering additional coronary flow parameters could further individualize and optimize the decision on revascularization. We aimed to investigate the potentially differential prognostic associations of elective percutaneous coronary intervention (PCI) according to coronary flow properties represented by coronary flow reserve (CFR), coronary flow capacity (CFC), and baseline CFC (bCFC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>From the ILIAS Registry (Inclusive Invasive Physiological Assessment in Angina Syndromes) composed of 16 hospitals globally from 7 countries, patients with obstructive coronary artery disease who underwent invasive coronary physiological assessment were included (N=2370 vessels). We assessed effect measure modifications of the association of PCI and 5-year target vessel failure according to CFR, CFC, and bCFC either assessed by Doppler-technique or thermodilution-method.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              The mean age of the population was 63.3 years, and there were 1322 (73.6%) males. Median fractional flow reserve was 0.85, and PCI was performed in 600 (25.3%) vessels. Reduced CFR, CFC, and abnormal bCFC were defined in 988 (41.7%), 542 (22.9%), and 600 (25.3%) vessels, respectively. Significant effect measure modifications were observed by CFC either in odds ratio (\n              <jats:italic>P<\/jats:italic>\n              =0.0018), additive (\n              <jats:italic>P<\/jats:italic>\n              =0.029), and hazard ratio scale (\n              <jats:italic>P<\/jats:italic>\n              =0.0002). The absolute risk of 5-year target-vessel failure was higher if treated by PCI in vessels with normal CFC by 1.8 (\u22121.7 to 5.3) percent, while that was lower by \u22125.9 (\u221212 to \u22120.1) percent in those with reduced CFC. CFR and bCFC were not significant effect modifiers in any scales. Similar associations were observed in per-patient analyses, whereas the findings were less robust.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>We observed qualitative effect measure modification of PCI and 5-year clinical outcomes according to CFC status in additive scale. CFR and bCFC were not robust effect modifiers. Therefore, CFC could be potentially used to optimize the patient selection for elective PCI treatment combined with fractional flow reserve.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.121.011948","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T18:00:52Z","timestamp":1655834452000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Differential Impact of Coronary Revascularization on Long-Term Clinical Outcome According to Coronary Flow Characteristics: Analysis of the International ILIAS Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-1983","authenticated-orcid":true,"given":"Rikuta","family":"Hamaya","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA (R.H.)."},{"name":"Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (R.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim P.","family":"van de Hoef","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC \u2013 location AMC, the Netherlands (T.P.v.d.H., C.K.M.B., S.A.J.C., J.J.P.)."},{"name":"Department of Cardiology, Amsterdam UMC \u2013 location VUmc, Amsterdam, the Netherlands (T.P.v.d.H., K.M., S.A.J.C., P.K.)."},{"name":"Department of Cardiology, NoordWest Ziekenhuisgroep, the Netherlands (T.P.v.d.H., G.A.d.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-4014","authenticated-orcid":true,"given":"Joo Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine, Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Seoul, Republic of Korea (J.M.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tsuchiura Kyodo General Hospital, Japan (M.H., Y.K., T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-4377","authenticated-orcid":true,"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tsuchiura Kyodo General Hospital, Japan (M.H., Y.K., T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-4296","authenticated-orcid":true,"given":"Tadashi","family":"Murai","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Yokosuka Kyosai Hospital, Japan (T.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-9623","authenticated-orcid":true,"given":"Coen K.M.","family":"Boerhout","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC \u2013 location AMC, the Netherlands (T.P.v.d.H., C.K.M.B., S.A.J.C., J.J.P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guus A.","family":"de Waard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, NoordWest Ziekenhuisgroep, the Netherlands (T.P.v.d.H., G.A.d.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Sejong General Hospital, Sejong Heart Institute, Bucheon, Korea (J.-H.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7826","authenticated-orcid":true,"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea (S.H.L.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hernan","family":"Mejia Renteria","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico San Carlos, IDISSC, and Universidad Complutense de Madrid, Spain (H.M.R., J.E.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Echavarria-Pinto","sequence":"additional","affiliation":[{"name":"Hospital General ISSSTE Quer\u00e9taro - Facultad de Medicina, Universidad Aut\u00f3noma de Quer\u00e9taro, M\u00e9xico (M.E.-P.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martijn","family":"Meuwissen","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine, Department of Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, MA (R.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-6533","authenticated-orcid":true,"given":"Hitoshi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Gifu Heart Center, Japan (H.M., M.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maribel","family":"Madera-Cambero","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tergooi Hospital, Blaricum, the Netherlands (M.M.-C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (A.E., E.H.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Effat","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Health and Diseases, Department of Internal Medicine (M.A.E.), University of Cincinnati, OH."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Marques","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam UMC \u2013 location VUmc, Amsterdam, the Netherlands (T.P.v.d.H., K.M., S.A.J.C., P.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon-Hyung","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea (J.-H.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evald H.","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (A.E., E.H.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7235-9560","authenticated-orcid":true,"given":"Rupak","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Mechanical and Materials Engineering Department (R.B.), University of Cincinnati, OH."},{"name":"Research Services, Veteran Affairs Medical Center, Cincinnati, OH (R.B.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-5774","authenticated-orcid":true,"given":"Chang-Wook","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (C.-W.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giampaolo","family":"Niccoli","sequence":"additional","affiliation":[{"name":"Catholic University of the Sacred Heart, Department of Cardiovascular Medicine, Institute of Cardiology, Rome, Italy (G.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8024-9620","authenticated-orcid":true,"given":"Masafumi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Gifu Heart Center, Japan (H.M., M.N.)."},{"name":"Toda Central General Hospital, Cardiovascular Center, Japan (M.N.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0117-8949","authenticated-orcid":true,"given":"Nobuhiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Medical University Hachioji Medical Center, Japan (N.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-6968","authenticated-orcid":true,"given":"Eun-Seok","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, South Korea (E.-S.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3582-6104","authenticated-orcid":true,"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Medical and 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