{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:39:03Z","timestamp":1791491943996,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Transcatheter closure of a symptomatic prosthetic paravalvular leak (PVL) is feasible, but there is presently no conclusive evidence to show consistent efficacy. We aimed to identify predictors of clinical success after transcatheter PVL closure.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Consecutive patients referred to 24 European centers for transcatheter PVL closure in 2017 to 2019 were included in a prospective registry (\n              <jats:italic>Fermeture de Fuite ParaProth\u00e9tique<\/jats:italic>\n              , FFPP). Clinical success was absence of any of the following within 1 month: re-admission for heart failure, blood transfusion, open-heart valvular surgery, and death.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              We included 216 symptomatic patients, who underwent 238 percutaneous PVL closure procedures on the mitral (64.3%), aortic (34.0%), or tricuspid (1.7%) valve. Symptoms were heart failure, hemolytic anemia, or both in 48.9%, 7.8%, and 43.3% of patients, respectively. One, 2, and 3 leaks were treated during the same procedure in 69.6%, 26.6%, and 3.8% of patients, respectively. The PVL was pinpoint or involved 1\/8 or 1\/4 of the valve circumference in 18.6%, 52.4%, and 28.1% of cases, respectively. The most frequently used devices were the Vascular Plug 3, Ventricular Septal Defect Occluder, Vascular Plug 2, and Paravalvular Leak Device (45.0%, 16.6%, 14.2%, and 13.6% of cases, respectively). Successful device(s) implantation with leak reduction to \u2264grade 2 was obtained in 85.0% of mitral and 91.4% of aortic procedures, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.164); with major periprocedural adverse event rates of 3.3% and 1.2%, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.371); and clinical success rates of 70.3% and 88.0%, respectively (\n              <jats:italic>P<\/jats:italic>\n              =0.004). By multivariate analysis, technical failure, mechanical valve, and hemolytic anemia were independently associated with absence of clinical success (odds ratios [95% CIs], 7.7 [2.0\u201325.0];\n              <jats:italic>P=<\/jats:italic>\n              0.002; 3.6 [1.1\u201311.1];\n              <jats:italic>P<\/jats:italic>\n              =0.036; and 3.7 [1.2\u201311.9];\n              <jats:italic>P<\/jats:italic>\n              =0.025; respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Transcatheter PVL closure is efficient and safe in symptomatic patients but is associated with a lower clinical success rate in patients with hemolysis and\/or a mechanical valve.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Registration:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifiers: NCT05089136\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.122.012193","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T18:00:19Z","timestamp":1666116019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Predictors of Clinical Success After Transcatheter Paravalvular Leak Closure: An International Prospective Multicenter Registry"],"prefix":"10.1161","volume":"15","clinical-trial-number":[{"clinical-trial-number":"nct05089136","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-0503","authenticated-orcid":true,"given":"S\u00e9bastien","family":"Hasco\u00ebt","sequence":"first","affiliation":[{"name":"H\u00f4pital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph, Facult\u00e9 de m\u00e9decine Paris-Saclay, Universit\u00e9 Paris-Saclay, France (S.H., D.B., M.K., B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Smolka","sequence":"additional","affiliation":[{"name":"Medical University of Silesia, Katowice, Poland (G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0606-9207","authenticated-orcid":true,"given":"David","family":"Blanchard","sequence":"additional","affiliation":[{"name":"H\u00f4pital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph, Facult\u00e9 de m\u00e9decine Paris-Saclay, Universit\u00e9 Paris-Saclay, France (S.H., D.B., M.K., B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Klo\u00ebckner","sequence":"additional","affiliation":[{"name":"H\u00f4pital Marie Lannelongue, Groupe Hospitalier Paris Saint Joseph, Facult\u00e9 de m\u00e9decine Paris-Saclay, Universit\u00e9 Paris-Saclay, France (S.H., D.B., M.K., B.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Brochet","sequence":"additional","affiliation":[{"name":"H\u00f4pital Bichat AP-HP, H\u00f4pital Bichat-Paris, Paris, France (E.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Bouisset","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toulouse Rangueil University Hospital, UMR 1295 INSERM, H\u00f4pital Rangueil, CHU Toulouse, Toulouse, France (F.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-3843","authenticated-orcid":true,"given":"Guillaume","family":"Leurent","sequence":"additional","affiliation":[{"name":"Department of cardiology, Universit\u00e9 Rennes, Inserm, LTSI \u2013 UMR1099, CHU Rennes, Rennes, France (G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Benoit","family":"Thambo","sequence":"additional","affiliation":[{"name":"CHU Haut L\u00e9v\u00eaque-Bordeaux, Pessac, France (J.-B.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-7791","authenticated-orcid":true,"given":"Nicolas","family":"Combes","sequence":"additional","affiliation":[{"name":"Clinique Pasteur, Toulouse, France (N.C., N.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dumonteil","sequence":"additional","affiliation":[{"name":"Clinique Pasteur, Toulouse, France 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