{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:38:28Z","timestamp":1791844708558,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>In recent years, transcatheter aortic valve replacement (TAVR) techniques and technology have continuously improved. Data regarding the impact of these advancements on outcomes in large real-world settings are still limited. The aim of this study was to investigate temporal trends and assess contemporary outcomes after TAVR with Evolut PRO\/PRO+ supra-annular self-expanding valves.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This study included patients enrolled in the multicenter NEOPRO (A Multicenter Comparison of Acurate NEO Versus Evolut PRO Transcatheter Heart Valves) and NEOPRO-2 (A Multicenter Comparison of ACURATE NEO2 Versus Evolut PRO\/PRO+ Transcatheter Heart Valves 2) registries who underwent transfemoral TAVR with Evolut PRO\/PRO+. Procedural dates (August 2017 through November 2021) were stratified in quartiles (Q) and used to investigate temporal trends in TAVR outcomes. Predischarge, 30-day Valve Academic Research Consortium-3 defined, and 1-year outcomes were evaluated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              In total, 1616 patients from 28 centers were included. Over time, patients had lower Society of Thoracic Surgeon-Predicted Risk of Mortality score (Q1\u20134, 4.1% [2.8\u20136.3%], 3.7% [2.6\u20135.3%], 3.3% [2.4\u20134.9%], 2.9% [2.2\u20134.3%];\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and more moderate or heavy valve calcification (Q1\u20134, 80%, 80%, 82%, 88%;\n              <jats:italic>P<\/jats:italic>\n              =0.038). Overall Valve Academic Research Consortium-3 technical success was 94.1%, with 30-day and 1-year all-cause mortality of 2.4% and 10%, respectively. Throughout the study period, procedures were associated with higher rates of 30-day device success (Q1\u20134, 81.2%, 82.2%, 82.0%, 88.0%; Cochran-Armitage\n              <jats:italic>P<\/jats:italic>\n              =0.023) and early safety (Q1\u20134, 66.8%, 67.5%, 74.0%, 77.6%; Cochran-Armitage\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001), with fewer permanent pacemaker implantations (Q1\u20134: 15.3%, 20.0%, 12.1%, 11.6%; Cochran-Armitage\n              <jats:italic>P<\/jats:italic>\n              =0.023) and residual mild or greater paravalvular leaks (Q1\u20134, 50.4%, 42.1%, 36.5%, 35.8%; Cochran-Armitage\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>TAVR with Evolut PRO\/PRO+ self-expanding valve is safe and effective. Despite the treatment of heavier calcified anatomies, procedural outcomes are improving over time with less need for pacemaker implantation and less significant paravalvular leaks.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.122.012538","type":"journal-article","created":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T19:00:31Z","timestamp":1673982031000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Temporal Trends and Contemporary Outcomes After Transcatheter Aortic Valve Replacement With Evolut PRO\/PRO+ Self-Expanding Valves: Insights From the NEOPRO\/NEOPRO-2 Registries"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-4384","authenticated-orcid":true,"given":"Andrea","family":"Scotti","sequence":"first","affiliation":[{"name":"Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (A.S., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2442-9982","authenticated-orcid":true,"given":"Sara","family":"Baggio","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (S.B., B.R., A.C., A.M.)."},{"name":"IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy (S.B., B.R., A.C., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pagnesi","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, ASST Spedali Civili di Brescia University of Brescia, Italy (M.P., M.A., M. Massussi)."},{"name":"Department of Medical Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.P., M.A., M. Massussi)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-5437","authenticated-orcid":true,"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Department of Cardiology, C.A.S.T. Policlinico G. Rodolico, Catania, Italy (M.B., G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Cardiothoracic Department, ASST Spedali Civili di Brescia University of Brescia, Italy (M.P., M.A., M. Massussi)."},{"name":"Department of Medical Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.P., M.A., M. Massussi)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-9057","authenticated-orcid":true,"given":"Amnon","family":"Eitan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Carmel Medical Center, Haifa, Israel (A.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5841-5514","authenticated-orcid":true,"given":"Rodrigo","family":"Est\u00e9vez-Loureiro","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospital Alvaro Cunqueiro, Galicia Sur Health Research Institute, Vigo, Spain (R.E.-L., R.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2744-2154","authenticated-orcid":true,"given":"Verena","family":"Veulemans","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital D\u00fcsseldorf, Germany (V.V., T.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-0298","authenticated-orcid":true,"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne, Department of Cardiology, Luzerner Kantonsspital, Lucerne, Switzerland (S.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Galway University Hospitals, Ireland (D.M., M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3554-6938","authenticated-orcid":true,"given":"Federico","family":"De Marco","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino IRCCS, Milan, Italy (F.D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1410","authenticated-orcid":true,"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, GVM Care and Research, Maria Cecilia Hospital, Cotignola, Italy (F.G., L.D.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5554-3577","authenticated-orcid":true,"given":"Marco","family":"Ferlini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy (M.F., G.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph K.","family":"Naber","sequence":"additional","affiliation":[{"name":"Contilia Heart and Vascular Centre, Elisabeth-Krankenhaus Essen, Germany (C.K.N., A.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Buono","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit, Fondazione Poliambulanza, Brescia, Italy (A.B., D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Schofer","sequence":"additional","affiliation":[{"name":"Department for Percutaneous Treatment of Structural Heart Disease, Albertinen Heart Center, Hamburg, Germany (J.S.)."},{"name":"MVZ Department Structural Heart Disease, Asklepios St Georg Clinic, Hamburg, Germany (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rottbauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Ulm, Germany (W.R., S.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-1205","authenticated-orcid":true,"given":"Nicolas M.","family":"Van Mieghem","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands (N.M.V.M., F.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saib","family":"Khogali","sequence":"additional","affiliation":[{"name":"Heart and Lung Center, New Cross Hospital, Wolverhampton, UK (S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Taramasso","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery, HerzZentrum Hirslanden Z\u00fcrich, Switzerland (M.T., M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-4068","authenticated-orcid":true,"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (T.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Malte","family":"Sinning","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center Bonn, University Hospital Bonn, Germany (J.-M.S., A. 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