{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:05:33Z","timestamp":1792091133997,"version":"4.4.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Anomalous aortic origin of coronary artery (AAOCA) with intramural segment is associated with risk of sudden cardiac death, probably related to a compressive mechanism exerted by the aorta. However, the intramural compression occurrence and magnitude during the cardiac cycle remain unknown. We hypothesized that (1) in end diastole, the intramural segment is narrower, more elliptic, and has greater resistance than extramural segment; (2) the intramural segment experiences a further compression in systole; and (3) morphometry and its systolic changes vary within different lumen cross-sections of the intramural segment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Phasic changes of lumen cross-sectional coronary area, roundness (minimum\/maximum lumen diameter), and hemodynamic resistance (Poiseuille law for noncircular sections) were derived from intravascular ultrasound pullbacks at rest for the ostial, distal intramural, and extramural segments. Data were obtained for 35 AAOCA (n=23 with intramural tract) after retrospective image-based gating and manual lumen segmentation. Differences between systolic and end-diastolic phases in each section, between sections of the same coronary, and between AAOCA with and without intramural tract were assessed by nonparametric statistical tests.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              In end diastole, both the ostial and distal intramural sections were more elliptical (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) than the reference extramural section and the correspondent sections in AAOCA without intramural segment. In systole, AAOCA with intramural segment showed a flattening at the ostium (\u22126.76% [10.82%];\n              <jats:italic>P<\/jats:italic>\n              =0.024) and a flattening (\u22125.36% [16.56%];\n              <jats:italic>P<\/jats:italic>\n              =0.011), a narrowing (\u22124.62% [11.38%];\n              <jats:italic>P<\/jats:italic>\n              =0.020), and a resistance increase (15.61% [30.07%];\n              <jats:italic>P<\/jats:italic>\n              =0.012) at the distal intramural section. No-intramural sections did not show morphological changes during the entire cardiac cycle.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>AAOCA with intramural segment has pathological segment-specific dynamic compression mainly in the systole under resting conditions. Studying AAOCA behavior with intravascular ultrasound during the cardiac cycle may help to evaluate and quantify the severity of the narrowing.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.122.012636","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T09:00:22Z","timestamp":1688720422000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Morphological Changes of Anomalous Coronary Arteries From the Aorta During the Cardiac Cycle Assessed by IVUS in Resting Conditions"],"prefix":"10.1161","volume":"16","author":[{"given":"Giovanni Maria","family":"Formato","sequence":"first","affiliation":[{"name":"3D and Computer Simulation Laboratory (G.M.F., A.R.), IRCCS Policlinico San Donato, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Luca","family":"Agnifili","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Cardiology (M.L.A., L.A., M.D., F.B.), IRCCS Policlinico San Donato, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Arzuffi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Cardiology (M.L.A., L.A., M.D., F.B.), IRCCS Policlinico San Donato, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3975-913X","authenticated-orcid":true,"given":"Antonio","family":"Rosato","sequence":"additional","affiliation":[{"name":"3D and Computer Simulation Laboratory (G.M.F., A.R.), IRCCS Policlinico San Donato, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Ceserani","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering and Architecture, University of Pavia, Italy (V.C., M.C., F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3840-1427","authenticated-orcid":true,"given":"Karina Geraldina","family":"Zuniga Olaya","sequence":"additional","affiliation":[{"name":"Department of Congenital Cardiac Surgery (K.G.Z.O., A.F., M.L.R.), IRCCS Policlinico San Donato, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Secchi","sequence":"additional","affiliation":[{"name":"Department of Radiology (F.S.), IRCCS Policlinico San Donato, Milan, Italy."},{"name":"Department of Biomedical Sciences for Health, Universit\u00e0 degli Studi di Milano, Milan, Italy (F.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Deamici","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Cardiology (M.L.A., L.A., M.D., F.B.), IRCCS Policlinico San Donato, Milan, 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