{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:38:38Z","timestamp":1790419118209,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Deciphering which patients with low-gradient aortic valve disease have severe stenosis can be difficult. We aimed to correlate the postextrasystolic potentiation (PESP) with dobutamine stress echocardiography and multidetector computed tomography in patients with low-gradient aortic valve stenosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>\n              Patients with an aortic valve area \u22641 cm\n              <jats:sup>2<\/jats:sup>\n              and a mean gradient &lt;40 mm\u2009Hg were included. Aortic valve stenosis severity was assessed by a core lab with dobutamine stress echocardiography, followed by a multidetector computed tomography aortic valve score if indeterminate. A premature ventricular contraction was induced by intentional catheter contact with the myocardium within the left ventricle. PESP was calculated as a percent change of pre-to-post mean gradient. Multidetector computed tomography was used to measure the aortic valve calcification score, and subsequently, aortic valve calcification density.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>\n              Twenty-eight patients (age, 77\u00b110 years; 19 female) were included. Dobutamine stress echocardiography increased mean gradient from baseline of 25\u00b17 mm\u2009Hg to 36\u00b111 mm\u2009Hg; pre-premature ventricular contraction mean gradient was 25\u00b17 mm\u2009Hg and increased to post-premature ventricular contraction mean gradient of 32\u00b110 mm\u2009Hg, representing a PESP of 24\u00b111%. A \u226520% in PESP resulted in 100% sensitivity, 77% specificity, 83% positive predictive value, and 100% negative predictive value for diagnosing severe aortic valve stenosis. There was a significant correlation between PESP and projected aortic valve area and aortic valve calcification density (R=\u22120.64,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.0003; R=0.057,\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.014, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>In patients with low-gradient aortic valve stenosis, catheter-induced premature ventricular contractions during cardiac catheterization causing \u226520% PESP has a 100% sensitivity for severe aortic valve stenosis. Validation of this 20% cutoff in larger groups with correlation to clinical end points is required.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.012892","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T09:00:42Z","timestamp":1682931642000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Catheter-Induced Postextrasystolic Potentiation in the Assessment of Severity of Low-Gradient Aortic Valve Stenosis"],"prefix":"10.1161","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-7989","authenticated-orcid":true,"given":"Payam","family":"Dehghani","sequence":"first","affiliation":[{"name":"Prairie Vascular Research Inc, Regina, Saskatchewan, Canada (P.D., J.S., J.B., A.J.L., R.H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Prairie Vascular Research Inc, Regina, Saskatchewan, Canada (P.D., J.S., J.B., A.J.L., R.H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Singer","sequence":"additional","affiliation":[{"name":"Western University, London, Ontario, Canada (Z.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8525-4928","authenticated-orcid":true,"given":"Jeffrey","family":"Booker","sequence":"additional","affiliation":[{"name":"Prairie Vascular Research Inc, Regina, Saskatchewan, Canada (P.D., J.S., J.B., A.J.L., R.H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea J.","family":"Lavoie","sequence":"additional","affiliation":[{"name":"Prairie Vascular Research Inc, Regina, Saskatchewan, Canada (P.D., J.S., J.B., A.J.L., R.H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney H.","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Prairie Vascular Research Inc, Regina, Saskatchewan, Canada (P.D., J.S., J.B., A.J.L., R.H.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay S.","family":"Shavadia","sequence":"additional","affiliation":[{"name":"University of Saskatchewan, Saskatoon, Canada (J.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"University of British Colombia, Vancouver, Canada (J.G.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8924-740X","authenticated-orcid":true,"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute - Laval University, Quebec City, Canada (M.-A.C., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":true,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute - Laval University, Quebec City, Canada (M.-A.C., P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw096"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000025611.21140.34"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.02.053"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.11.052"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.117.007146"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2021.11.009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1810130604"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12574-019-00422-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.44.4.523"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.74.1.10"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.557678"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.757427"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2015.01.009"},{"key":"e_1_3_3_15_2","first-page":"203","article-title":"Measures of diagnostic accuracy: basic definitions.","volume":"19","author":"\u0160imundi\u0107 AM","year":"2009","unstructured":"\u0160imundi\u0107, AM. 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