{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:00Z","timestamp":1787018040786,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>We assessed the safety profile of tricuspid transcatheter edge-to-edge repair (TEER) in patients with right ventricular (RV) dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We identified patients undergoing TEER to treat tricuspid regurgitation from June 2015 to October 2021 and assessed tricuspid annular plane systolic excursion (TAPSE) and RV fractional area change (RVFAC). RV dysfunction was defined as TAPSE &lt;17 mm and RVFAC &lt;35%. The primary end point was 30-day mortality after TEER. We also investigated the change in the RV function in the early phase and clinical outcomes at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The study participants (n=262) were at high surgical risk (EuroSCORE II, 6.2% [interquartile range, 4.0%\u201310.3%]). Among them, 44 patients met the criteria of RV dysfunction. Thirty-day mortality was 3.2% in patients with normal RV function and 2.3% in patients with RV dysfunction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.99). Tricuspid regurgitation reduction to \u22642+ was consistently achieved irrespective of RV dysfunction (76.5% versus 70.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.44). TAPSE and RVFAC declined after TEER in patients with normal RV function (TAPSE, 19.0\u00b14.7 to 17.9\u00b14.5 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001; RVFAC, 46.2%\u00b18.1% to 40.3%\u00b19.7%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). In contrast, those parameters were unchanged or tended to increase in patients with RV dysfunction (TAPSE, 13.2\u00b12.3 to 15.3\u00b14.7 mm;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.011; RVFAC, 29.6%\u00b14.1% to 31.6%\u00b18.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.14). Two years after TEER, compared with patients with normal RV function, patients with RV dysfunction had significantly higher mortality (27.0% versus 56.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>TEER was safe and feasible to treat tricuspid regurgitation in patients with RV dysfunction. The decline in the RV function was observed in patients with normal RV function but not in patients with RV dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013156","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T05:09:59Z","timestamp":1713330599000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Outcomes of Transcatheter Tricuspid Edge-to-Edge Repair in Patients With Right Ventricular Dysfunction"],"prefix":"10.1161","volume":"17","author":[{"given":"Johanna","family":"Vogelhuber","sequence":"first","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0780-8689","authenticated-orcid":true,"given":"Tetsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4035-1142","authenticated-orcid":true,"given":"Refik","family":"Kavsur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5880-2968","authenticated-orcid":true,"given":"Tadahiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Japan (T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-2488","authenticated-orcid":true,"given":"Can","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Silaschi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery (M.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-9963","authenticated-orcid":true,"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II (J.V., T.T., R.K., C.O., G.N., S.Z., M.W., A.S.), Heart Center Bonn, University Hospital Bonn, 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