{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:03:39Z","timestamp":1792713819202,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The efficacy and safety of each third-generation drug-eluting stent with ultrathin struts and advanced polymer technology remain unclear. We investigated the clinical outcomes of percutaneous coronary intervention using the Coroflex ISAR polymer-free sirolimus-eluting stent (SES) or Orsiro biodegradable polymer SES.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>The HOST-IDEA trial (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis\u2013Coronary Intervention With Next-Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy), initially designed with a 2\u00d72 factorial approach, sought to randomize patients undergoing percutaneous coronary intervention based on dual antiplatelet therapy duration (3 versus 12 months) and stent type (Coroflex ISAR versus Orsiro). Despite randomizing 2013 patients for dual antiplatelet therapy duration, the stent arm transitioned to a registry format during the trial. Among these, 328 individuals (16.3%) were randomized for Coroflex ISAR or Orsiro SES, while 1685 (83.7%) underwent percutaneous coronary intervention without stent-type randomization. In this study, the Coroflex ISAR (n=559) and Orsiro groups (n=1449) were matched using a propensity score. The prespecified primary end point was target lesion failure, a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization at 12 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              The baseline patient and procedural characteristics were well balanced between the Coroflex ISAR and Orsiro groups after propensity score matching (n=559, each group). The Coroflex ISAR group was significantly associated with a higher rate of target lesion failure, mainly driven by clinically driven target lesion revascularization, compared with the Orsiro group (3.4% versus 1.1%; hazard ratio, 3.21 [95% CI, 1.28\u20138.05];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.01). A higher risk of target lesion failure in the Coroflex ISAR group was consistently observed across various subgroups. The rates of any bleeding (hazard ratio, 0.85 [95% CI, 0.51\u20131.40];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.52) and major bleeding (hazard ratio, 1.58 [95% CI, 0.61\u20134.08];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.34) were comparable between the 2 groups.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this propensity score-matched analysis of the stent arm registry from the HOST-IDEA trial, the Orsiro SES was associated with significantly better outcomes in terms of 1-year target lesion failure, mainly driven by clinically driven target lesion revascularization, than the Coroflex ISAR SES.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02601157.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013585","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:14:14Z","timestamp":1716556454000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Biodegradable Polymer Versus Polymer-Free Ultrathin Sirolimus-Eluting Stents: Analysis of the Stent Arm Registry From the HOST-IDEA Randomized Trial"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02601157","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-0747","authenticated-orcid":true,"given":"Jung-Kyu","family":"Han","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-3930","authenticated-orcid":true,"given":"Seokhun","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Hyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-2351","authenticated-orcid":true,"given":"Han-Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-4432","authenticated-orcid":true,"given":"Kyung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-1746","authenticated-orcid":true,"given":"Hyun-Jae","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-3348","authenticated-orcid":true,"given":"Bon-Kwon","family":"Koo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., S. Yang, D.H., S.-H. Park, J. Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3696-3557","authenticated-orcid":true,"given":"Jin-Man","family":"Cho","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea (J.-M. Cho)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-0017","authenticated-orcid":true,"given":"Janghyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Saint Carollo Hospital, Sun-cheon, Republic of Korea (J. Cho)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duk Won","family":"Bang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea (D.W.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-7760","authenticated-orcid":true,"given":"Jae-Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Chungnam National University Sejong Hospital, Chungnam National University School of Medicine, Republic of Korea (J.-H. Lee)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Cheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea (H.C. Lee)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-3284","authenticated-orcid":true,"given":"Kyung-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ewha Womans University Medical Center, Ewha Womans University School of Medicine, Seoul, Republic of Korea (K.-J. Kim)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo Jung","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Republic of Korea (W.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Woo","family":"Seo","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea (W.-W.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jung","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Hallym University Pyeongchon Sacred Heart Hospital, Anyang, Republic of Korea (W.-J. 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Kang, H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. Kim)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M. Yang, K.W. Park, H.-J. Kang, B.-K.K., H.-S. 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