{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:23:32Z","timestamp":1790717012670,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Comparative data on transcatheter self-expanding ACURATE neo2 (NEO2) and balloon-expandable SAPIEN 3 Ultra prostheses in technically challenging anatomy of severe aortic valve calcified aortic annuli are scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              A total of 1987 patients with severe native aortic stenosis treated with the self-expanding NEO2 (n=1457) or balloon-expandable SAPIEN 3 Ultra (n=530) from January 2017 to April 2023 were evaluated. The primary end point was procedural outcome according to the Valve Academic Research Consortium 3 definitions. Propensity matching defined 219 pairs with severe calcification (calcium density cutoff, 758 AU\/cm\n              <jats:sup>2<\/jats:sup>\n              ) of the native aortic valve.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Technical success (90.4% versus 91.8%; risk difference, 1.4% [95% CI, \u22124.4 to \u22127.2];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.737) and device success at 30 days (80.8% versus 75.8%; risk difference, \u22125.0% [95% CI, \u221213.2 to 3.1];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.246) were comparable between NEO2 and SAPIEN 3 Ultra. The rate of severe prosthesis-patient mismatch (1.1% versus 10.1%; risk difference, 10.0% [95% CI, 4.0\u201313.9];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and mean transvalvular gradient \u226520 mm\u2005Hg (2.8% versus 14.3%; risk difference, 11.5% [95% CI, 5.8\u201317.1];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) was lower with NEO2. The rate of more-than-mild paravalvular leakage or valve-in-valve due to paravalvular leakage was significantly higher (6.2% versus 0.0%; risk difference, 6.2% [95% CI, \u221210.1 to \u22122.7];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.002), and there was a tendency for a higher rate of device embolization or migration (1.8% versus 0.0%; risk difference, \u22121.8% [95% CI, \u22124.1 to 0.4];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.123) with NEO2. Multivarate regression revealed no independent impact of transcatheter heart valve selection on device success (odds ratio, 0.93 [95% CI, 0.48\u20131.77];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.817).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients with severely calcified annuli, supraannular implantation of NEO2 showed hemodynamic advantages. Nevertheless, NEO2 was associated with a higher incidence of relevant paravalvular leakage and a numerically higher rate of device embolization than SAPIEN 3 Ultra in this particular patient group.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013608","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T09:02:11Z","timestamp":1711443731000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["ACURATE neo2 Versus SAPIEN 3 Ultra Transcatheter Heart Valve in Severe Aortic Valve Calcification: A Propensity-Matched Analysis"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-8096","authenticated-orcid":true,"given":"Clemens","family":"Eckel","sequence":"first","affiliation":[{"name":"Department of Cardiology, St. Johannes Hospital, Dortmund, Germany (C.E., D.S., C.G., V.T., H.M., J.B.)."},{"name":"Department of Cardiology, University of Oldenburg, Germany (C.E., A.E., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":true,"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (W.-K.K., M.R.), Kerckhoff Heart Center, Bad Nauheim, Germany."},{"name":"Cardiac Surgery (W.-K.K., M.R., E.I.C., Y.-H.C.), Kerckhoff Heart Center, Bad Nauheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"S\u00f6temann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Johannes Hospital, Dortmund, Germany (C.E., D.S., C.G., V.T., H.M., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Grothusen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Johannes Hospital, Dortmund, Germany (C.E., D.S., C.G., V.T., H.M., J.B.)."},{"name":"Department of Cardiac Surgery, University of Kiel, Germany (C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2289-5613","authenticated-orcid":true,"given":"Vedat","family":"Tiyerili","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Johannes Hospital, Dortmund, Germany (C.E., D.S., C.G., V.T., H.M., J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6577-7898","authenticated-orcid":true,"given":"Guido","family":"Dohmen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, St. Johannes Hospital, Dortmund, Germany (G.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Renker","sequence":"additional","affiliation":[{"name":"Departments of Cardiology (W.-K.K., M.R.), Kerckhoff Heart Center, Bad Nauheim, Germany."},{"name":"Cardiac Surgery (W.-K.K., M.R., E.I.C., Y.-H.C.), Kerckhoff Heart Center, Bad Nauheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios I.","family":"Charitos","sequence":"additional","affiliation":[{"name":"Cardiac Surgery (W.-K.K., M.R., E.I.C., Y.-H.C.), Kerckhoff Heart Center, Bad Nauheim, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Giessen, Germany (C.W.H.)."},{"name":"German Center for Cardiovascular Research, Partner Site RheinMain, Bad Nauheim, Germany (C.W.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-9926","authenticated-orcid":true,"given":"Yeong-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Cardiac Surgery (W.-K.K., M.R., E.I.C., Y.-H.C.), Kerckhoff Heart Center, Bad Nauheim, 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