{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:12:17Z","timestamp":1791328337439,"version":"4.3.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Patients with an indication for oral anticoagulation who undergo percutaneous coronary intervention require a combination of oral anticoagulation and antiplatelet therapy. The use of a coronary stent with a thromboresistant and pro-healing coating may allow an abbreviated duration of dual antiplatelet therapy (DAPT) without an increase in the risk of thromboembolic events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Patients with an indication for oral anticoagulation undergoing percutaneous coronary intervention were randomized to treatment with the COBRA polyzene F (PzF) stent followed by 14 days of DAPT or a Food and Drug Administration\u2013approved new-generation drug-eluting stent followed by 3 or 6 months of DAPT. The bleeding coprimary end point was Bleeding Academic Research Consortium type \u22652 beyond 14 days (or after hospital discharge) until 6 months. The thromboembolic coprimary end point was the composite of all-cause death, myocardial infarction, definite or probable stent thrombosis, or ischemic stroke at 6 months. The trial hypothesis was that the COBRA PzF stent strategy would be superior with respect to bleeding events and noninferior with respect to thromboembolic events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 996 patients underwent randomization. The bleeding end point occurred in 37 of 475 patients (7.8%) in the COBRA PzF group and 47 of 482 patients (9.8%) in the control group (difference, \u22122.0 [95% CI, \u22125.6 to 1.6];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.14). The thromboembolic end point occurred in 37 of 492 patients (7.5%) in the COBRA PzF group and 24 of 490 patients (4.9%) in the control group (difference, 2.6%; prespecified noninferiority margin 5%, upper limit of 1-sided 95% CI of the difference, 5.2%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>noninferiority<\/jats:sub>\n              =0.07).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients with an indication for oral anticoagulation undergoing percutaneous coronary intervention, treatment with the COBRA PzF stent plus 14 days of DAPT was not superior with respect to bleeding events and was not noninferior with respect to thromboembolic events at 6 months compared with treatment with standard Food and Drug Administration\u2013approved drug-eluting stent plus 3 to 6 months of DAPT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02594501.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013735","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T18:01:03Z","timestamp":1729015263000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Randomized Trial of COBRA PzF Stenting to Reduce the Duration of Triple Therapy: The COBRA-REDUCE Trial"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02594501","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-6393","authenticated-orcid":true,"given":"Robert A.","family":"Byrne","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute, Mater Private Network, Dublin, Ireland (R.A.B., R.C., J.J.C.)."},{"name":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin (R.A.B., R.C., J.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f3is\u00edn","family":"Colleran","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Mater Private Network, Dublin, Ireland (R.A.B., R.C., J.J.C.)."},{"name":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin (R.A.B., R.C., J.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6086-3279","authenticated-orcid":true,"given":"J.J.","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute, Mater Private Network, Dublin, Ireland (R.A.B., R.C., J.J.C.)."},{"name":"School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, Dublin (R.A.B., R.C., J.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0308-4591","authenticated-orcid":true,"given":"Rajiv","family":"Jauhar","sequence":"additional","affiliation":[{"name":"North Shore University Hospital, Manhasset, NY (R.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-3045","authenticated-orcid":true,"given":"Luc","family":"Maillard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Groupement de Coop\u00e9ration Sanitaire Axium Rambot, Aix-en-Provence, France (L.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"De Labriolle","sequence":"additional","affiliation":[{"name":"Clinique du Pont de Chaume, Montauban, France (A.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-6433","authenticated-orcid":true,"given":"Michael","family":"Maeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Denmark (M.M.)."},{"name":"Department of Clinical Medicine, Aarhus University, Denmark (M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Croft","sequence":"additional","affiliation":[{"name":"Homes Regional Medical Centre, Melbourne, FL (C.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0287-9560","authenticated-orcid":true,"given":"Michael","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Medical Intensive Care, St Josefskrankenhaus, Freiburg, Germany (M. Brunner)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Leistner","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Angiology, and Intensive Care Medicine, Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Germany (D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Zrenner","sequence":"additional","affiliation":[{"name":"Medizinische Klinik I, Krankenhaus Landshut-Achdorf, Germany (B.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Kollum","sequence":"additional","affiliation":[{"name":"Study Center of the Hegau-Bodensee Klinikum Singen, Germany (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-4846","authenticated-orcid":true,"given":"Karl-Ludwig","family":"Laugwitz","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (K.-L.L.)."},{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Germany (K.-L.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-2819","authenticated-orcid":true,"given":"Erion","family":"Xhepa","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz und Kreislauferkrankungen, Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (E.X., K.M., S.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Mayer","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz und Kreislauferkrankungen, Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (E.X., K.M., S.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shqipdona","family":"Lahu","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Herz und Kreislauferkrankungen, Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (E.X., K.M., S.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-8310","authenticated-orcid":true,"given":"Michael","family":"Joner","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Germany (K.-L.L., M.J., A. Kastrati)."},{"name":"Klinik f\u00fcr Herz und Kreislauferkrankungen, Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (E.X., K.M., S.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-1058","authenticated-orcid":true,"given":"Ajay","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Irving Medical Center\/New York Presbyterian Hospital, NY; Cardiovascular Research Foundation, New York, NY (A. Kirtane)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-262X","authenticated-orcid":true,"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, New York, NY (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Barakat","sequence":"additional","affiliation":[{"name":"Celonova Biosciences Inc, San Antonio, TX (M. Barakat)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Urban","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Tour, Geneva, Switzerland (P.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-9893","authenticated-orcid":true,"given":"Donald E.","family":"Cutlip","sequence":"additional","affiliation":[{"name":"Baim Institute for Clinical Research, Boston, MA (D.E.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-891X","authenticated-orcid":true,"given":"Adnan","family":"Kastrati","sequence":"additional","affiliation":[{"name":"DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Germany (K.-L.L., M.J., A. Kastrati)."},{"name":"Klinik f\u00fcr Herz und Kreislauferkrankungen, Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t M\u00fcnchen, Munich, Germany (E.X., K.M., S.L., M.J., A. Kastrati)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the COBRA-REDUCE Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817083"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708454"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31872-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611594"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(12)62177-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.050"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz372"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28045"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.053"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.4244\/eij-d-20-00749"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt115"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.762047"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.01.022"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2017-0103"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.10.037"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.11.005"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.07.181"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00740"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.10.007"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29065"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.115.003519"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2108749"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa575"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.050438"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcvp\/pvaa116"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz732"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac294"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.123.013735","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:15Z","timestamp":1748552955000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.123.013735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":28,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.123.013735"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.123.013735","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-05-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}