{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:11:58Z","timestamp":1791879118151,"version":"4.3.4"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Complete revascularization improves cardiovascular outcomes compared with culprit-only revascularization in patients with acute myocardial infarction ([MI]; ST-segment\u2013elevation MI or non\u2013ST-segment\u2013elevation MI) and multivessel coronary artery disease. However, the timing of complete revascularization (single-setting versus staged revascularization) is uncertain. The aim was to compare the outcomes of single-setting complete, staged complete, and culprit vessel\u2013only revascularization in patients with acute MI and multivessel disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      PubMed, EMBASE, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      databases were searched for randomized controlled trials that compared 3 revascularization strategies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>From 16 randomized controlled trials that randomized 11\u2009876 patients with acute MI and multivessel disease, both single-setting complete and staged complete revascularization reduced primary outcome (cardiovascular mortality\/MI; odds ratio [OR], 0.52 [95% CI, 0.41\u20130.65]; OR, 0.74 [95% CI, 0.62\u20130.88]), composite of all-cause mortality\/MI (OR, 0.52 [95% CI, 0.40\u20130.67]; OR, 0.78 [95% CI, 0.67\u20130.91]), major adverse cardiovascular event (OR, 0.42 [95% CI, 0.32\u20130.56]; OR, 0.62 [95% CI, 0.47\u20130.82]), MI (OR, 0.39 [95% CI, 0.26\u20130.57]; OR, 0.73 [95% CI, 0.59\u20130.90]), and repeat revascularization (OR, 0.30 [95% CI, 0.18\u20130.47]; OR, 0.46 [95% CI, 0.30\u20130.71]) compared with culprit-only revascularization. Single-setting complete revascularization reduced cardiovascular mortality\/MI (OR, 0.70 [95% CI, 0.55\u20130.91]), major adverse cardiovascular event (OR, 0.67 [95% CI, 0.50\u20130.91]), and all-cause mortality\/MI driven by a lower risk of MI (OR, 0.53 [95% CI, 0.36\u20130.77]) compared with staged complete revascularization. Single-setting complete revascularization ranked number 1, followed by staged complete revascularization (number 2) and culprit-only revascularization (number 3) for all outcomes. The results were largely consistent in subgroup analysis comparing ST-segment\u2013elevation MI versus non\u2013ST-segment\u2013elevation MI cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Single-setting complete revascularization may offer the greatest reductions in cardiovascular events in patients with acute MI and multivessel disease. A large-scale randomized trial of single-setting complete versus staged complete revascularization is warranted to evaluate the optimal timing of complete revascularization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013737","type":"journal-article","created":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T05:00:46Z","timestamp":1720414846000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Culprit-Only Revascularization, Single-Setting Complete Revascularization, and Staged Complete Revascularization in Acute Myocardial Infarction: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-4448","authenticated-orcid":true,"given":"Muhammad Haisum","family":"Maqsood","sequence":"first","affiliation":[{"name":"Department of Cardiology, DeBakey Heart and Vascular Center, The Methodist Hospital, Houston, TX (M.H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-8769","authenticated-orcid":true,"given":"Jacqueline E.","family":"Tamis-Holland","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Heart, Vascular and Thoracic Institute, OH (J.E.T.-H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-0894","authenticated-orcid":true,"given":"Sunil V.","family":"Rao","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, New York University Grossman School of Medicine (S.V.R., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3416-8210","authenticated-orcid":true,"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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