{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:58:18Z","timestamp":1792029498384,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Transcatheter mitral valve-in-valve replacement offers a less-invasive alternative for high-risk patients with bioprosthetic valve failure. Limited experience exists in intermediate-risk patients. We aim to evaluate 1-year outcomes of the PARTNER 3 mitral valve-in-valve study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This prospective, single-arm, multicenter study enrolled symptomatic patients with a failing mitral bioprosthesis demonstrating greater than or equal to moderate stenosis and regurgitation and Society of Thoracic Surgeons score \u22653% and &lt;8%. A balloon-expandable transcatheter heart valve (SAPIEN 3, Edwards Lifesciences) was used via a transeptal approach. The primary end point was the composite of all-cause mortality and stroke at 1 year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>A total of 50 patients from 12 sites underwent mitral valve-in-valve from 2018 to 2021. The mean age was 70.1\u00b19.7 years, mean Society of Thoracic Surgeons score was 4.1%\u00b11.6%, and 54% were female. There were no primary end point events (mortality or stroke) through 1 year, and no left-ventricular outflow tract obstruction, endocarditis, or mitral valve reintervention was reported. Six patients (12%) required rehospitalization, including heart failure (n=2), minor procedural side effects (n=2), and valve thrombosis (n=2; both resolved with anticoagulation). An additional valve thrombosis was associated with no significant clinical sequelae. From baseline to 1 year, all subjects with available data had none\/trace or mild (grade 1+) mitral regurgitation and the New York Heart Association class improved in 87.2% (41\/47) of patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Mitral valve-in-valve with a balloon-expandable valve via transseptal approach in intermediate-risk patients was associated with improved symptoms and quality of life, adequate transcatheter valve performance, and no mortality or stroke at 1-year follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03193801.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013782","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T09:00:48Z","timestamp":1721638848000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["One-Year Outcomes of Transseptal Mitral Valve-in-Valve in Intermediate Surgical Risk Patients"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct03193801","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0704-0334","authenticated-orcid":true,"given":"S. Chris","family":"Malaisrie","sequence":"first","affiliation":[{"name":"Northwestern University, Chicago, IL (S.C.M., C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":true,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Mayo Clinic, Rochester, MN (M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-9995","authenticated-orcid":true,"given":"Charles","family":"Davidson","sequence":"additional","affiliation":[{"name":"Northwestern University, Chicago, IL (S.C.M., C.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew","family":"Williams","sequence":"additional","affiliation":[{"name":"NYU Langone Medical Center, New York, NY (M.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"F\u00e1bio S\u00e2ndoli","family":"de Brito","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil (F.S.d.B., A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8689-9990","authenticated-orcid":true,"given":"Alexandre","family":"Abizaid","sequence":"additional","affiliation":[{"name":"Instituto do Cora\u00e7\u00e3o da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil (F.S.d.B., A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7557","authenticated-orcid":true,"given":"Pinak","family":"Shah","sequence":"additional","affiliation":[{"name":"Brigham and Women\u2019s Hospital, Boston, MA (P.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6500-7471","authenticated-orcid":true,"given":"Tsuyoshi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Washington University, Barnes-Jewish Hospital, St. Louis, MO (T.K., A.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Poon","sequence":"additional","affiliation":[{"name":"Prince Charles Hospital, Brisbane, Australia (K.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-7905","authenticated-orcid":true,"given":"Justin","family":"Levisay","sequence":"additional","affiliation":[{"name":"NorthShore University Health System, Evanston, IL (J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-798X","authenticated-orcid":true,"given":"Xiao","family":"Yu","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Irvine, CA (X.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":true,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Laval, Qu\u00e9bec City, Canada (P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-9191","authenticated-orcid":true,"given":"Rebecca T.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Columbia University, New York (R.T.H., M.B.L.)."},{"name":"Cardiovascular Research Foundation, New York (R.T.H., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Blanke","sequence":"additional","affiliation":[{"name":"St. Paul\u2019s Hospital, Vancouver, BC, Canada (P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University, New York (R.T.H., M.B.L.)."},{"name":"Cardiovascular Research Foundation, New York (R.T.H., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3148-9158","authenticated-orcid":true,"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Baylor Scott &amp; White Health, Plano, TX (M.J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Zajarias","sequence":"additional","affiliation":[{"name":"Washington University, Barnes-Jewish Hospital, St. Louis, MO (T.K., A.Z.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the PARTNER 3 Mitral Valve-in-Valve Study Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000923"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.10.012"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2020-0477"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.049"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2022.05.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy029"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.01.046"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2008.05.068"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008425"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2020.2974"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000089184.46999.f4"},{"key":"e_1_3_3_13_2","first-page":"376","article-title":"Multiple valve replacement increases the risk of reoperation for structural degeneration of bioprostheses.","volume":"8","author":"Caus T","year":"1999","unstructured":"Caus T, Albertini JN, Chi Y, Collart F, Monties JR, Mesana T. Multiple valve replacement increases the risk of reoperation for structural degeneration of bioprostheses. J Heart Valve Dis. 1999;8:376\u2013383.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_3_14_2","first-page":"646","article-title":"Reoperation in patients with a bioprosthesis in the mitral position: indications and early results.","volume":"2","author":"Mazzucco A","year":"1993","unstructured":"Mazzucco A, Milano A, Mazzaro E, Bortolotti U. Reoperation in patients with a bioprosthesis in the mitral position: indications and early results. J Heart Valve Dis. 1993;2:646\u2013648.","journal-title":"J Heart Valve Dis"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.12.033"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.09.015"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049088"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.02.027"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020948"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.12.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27447"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2022.11.043"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.09.022"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2022.100077"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019854"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.123.013782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:21Z","timestamp":1748552961000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.123.013782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.123.013782"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.123.013782","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"2023-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}