{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:01:51Z","timestamp":1787313711116,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The Murray law\u2013based quantitative flow ratio (\u03bcFR) is an emerging technique that requires only 1 projection of coronary angiography with similar accuracy to quantitative flow ratio (QFR). However, it has not been validated for the evaluation of noninfarct-related artery (non-IRA) in acute myocardial infarction (AMI) settings. Therefore, our study aimed to evaluate the diagnostic accuracy of \u03bcFR and the safety of deferring non-IRA lesions with \u03bcFR &gt;0.80 in the setting of AMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\u03bcFR and QFR were analyzed for non-IRA lesions of patients with AMI enrolled in the FRAME-AMI trial (Fractional Flow Reserve Versus Angiography-Guided Strategy for Management of Non-Infarction Related Artery Stenosis in Patients With Acute Myocardial Infarction), consisting of fractional flow reserve (FFR)\u2013guided percutaneous coronary intervention and angiography-guided percutaneous coronary intervention groups. The diagnostic accuracy of \u03bcFR was compared with QFR and FFR. Patients were classified by the non-IRA \u03bcFR value of 0.80 as a cutoff value. The primary outcome was a vessel-oriented composite outcome, a composite of cardiac death, non-IRA\u2013related myocardial infarction, and non-IRA\u2013related repeat revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      \u03bcFR and QFR analyses were feasible in 443 patients (552 lesions). \u03bcFR showed acceptable correlation with FFR (R=0.777;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), comparable C-index with QFR to predict FFR \u22640.80 (\u03bcFR versus QFR: 0.926 versus 0.961,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.070), and shorter total analysis time (mean, 32.7 versus 186.9 s;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Non-IRA with \u03bcFR &gt;0.80 and deferred percutaneous coronary intervention had a significantly lower risk of vessel-oriented composite outcome than non-IRA with performed percutaneous coronary intervention (3.4% versus 10.5%; hazard ratio, 0.37 [95% CI, 0.14\u20130.99];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with multivessel AMI, \u03bcFR of non-IRA showed acceptable diagnostic accuracy comparable to that of QFR to predict FFR \u22640.80. Deferred non-IRA with \u03bcFR &gt;0.80 showed a lower risk of vessel-oriented composite outcome than revascularized non-IRA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT02715518.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013844","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T14:06:08Z","timestamp":1716300368000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Value of Single-Projection Angiography\u2013Derived FFR in Noninfarct-Related Artery"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02715518","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3963-3142","authenticated-orcid":true,"given":"Woochan","family":"Kwon","sequence":"first","affiliation":[{"name":"Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (W.K., K.H.C., D.H., T.K.P., J.H.Y., Y.B.S., S.-H.C., H.-C.G., J.-Y.H., J.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-9581","authenticated-orcid":true,"given":"Ki Hong","family":"Choi","sequence":"additional","affiliation":[{"name":"Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (W.K., K.H.C., D.H., T.K.P., J.H.Y., Y.B.S., S.-H.C., H.-C.G., J.-Y.H., J.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7826","authenticated-orcid":true,"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea (S.H.L., M.C.K., Y.J.H., M.H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-0486","authenticated-orcid":true,"given":"David","family":"Hong","sequence":"additional","affiliation":[{"name":"Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea (W.K., K.H.C., D.H., T.K.P., J.H.Y., Y.B.S., S.-H.C., H.-C.G., J.-Y.H., J.M.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-5732","authenticated-orcid":true,"given":"Doosup","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Duke University Medical Center, Durham, NC (D.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4554-041X","authenticated-orcid":true,"given":"Hyun Kuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Chosun University Hospital, University of Chosun College of Medicine, Gwangju, South Korea (H.K.K., K.H.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-4954","authenticated-orcid":true,"given":"Keun Ho","family":"Park","sequence":"additional","affiliation":[{"name":"Chosun University Hospital, University of Chosun College of Medicine, Gwangju, South Korea (H.K.K., K.H.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3166-3176","authenticated-orcid":true,"given":"Eun Ho","family":"Choo","sequence":"additional","affiliation":[{"name":"Seoul St. Mary\u2019s Hospital, The Catholic University of Korea, South Korea (E.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea, Uijeongbu St. Mary\u2019s Hospital, Seoul, South Korea (C.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-1702","authenticated-orcid":true,"given":"Min Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea (S.H.L., M.C.K., Y.J.H., M.H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0192-8161","authenticated-orcid":true,"given":"Young Joon","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea (S.H.L., M.C.K., Y.J.H., M.H.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1528-2739","authenticated-orcid":true,"given":"Sung Gyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, South Korea (S.G.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-9564","authenticated-orcid":true,"given":"Joon-Hyung","family":"Doh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Inje University Ilsan Paik Hospital, Goyang, South Korea (J.-H.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1386-349X","authenticated-orcid":true,"given":"Sang Yeub","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung-Ang University College of Medicine, Chung-Ang University Gwangmyeong Hospital, South Korea (S.Y.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-9988","authenticated-orcid":true,"given":"Sang Don","family":"Park","sequence":"additional","affiliation":[{"name":"Inha University Hospital, Incheon, South Korea (S.D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1260-0778","authenticated-orcid":true,"given":"Hyun-Jong","family":"Lee","sequence":"additional","affiliation":[{"name":"Sejong General Hospital, Bucheon, South Korea (H.-J.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-1798","authenticated-orcid":true,"given":"Min Gyu","family":"Kang","sequence":"additional","affiliation":[{"name":"Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, South Korea (M.G.K., J.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-7411","authenticated-orcid":true,"given":"Jin-Sin","family":"Koh","sequence":"additional","affiliation":[{"name":"Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju, South Korea (M.G.K., J.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-0971","authenticated-orcid":true,"given":"Yun-Kyeong","family":"Cho","sequence":"additional","affiliation":[{"name":"Keimyung University Dongsan Medical Center, Daegu, South Korea (Y.-K.C., 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Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.123.013844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T17:09:13Z","timestamp":1748538553000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.123.013844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.123.013844"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.123.013844","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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