{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T16:55:22Z","timestamp":1778172922714,"version":"3.51.4"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["K23HL150315"],"award-info":[{"award-number":["K23HL150315"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["T32HL098129"],"award-info":[{"award-number":["T32HL098129"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Coronary slow flow (CSF) by invasive coronary angiography is frequently understood to be an indicator of coronary microvascular dysfunction (CMD) in patients with ischemia with nonobstructive coronary arteries. However, the relationship between visual estimates of CSF and quantitative wire-based invasive diagnosis of CMD is uncertain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>We prospectively enrolled adults aged \u226518 years with stable ischemic heart disease who were referred for invasive coronary angiography. Individuals with \u226550% epicardial coronary artery stenosis were excluded. Invasive coronary angiography was reviewed for CSF, defined as \u22653 cardiac cycles to opacify distal vessels with contrast. Coronary function testing was performed in the left anterior descending coronary artery using bolus coronary thermodilution techniques to measure coronary flow reserve (CFR) and the index of microcirculatory resistance (IMR). Invasively determined CMD was defined as abnormal CFR (&lt;2.5), abnormal IMR (\u226525), or both.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Among 104 participants, the median age was 61.5 years and 79% were female. The median CFR was 3.6 (interquartile range, 2.5\u20134.7) and the median IMR was 21 (interquartile range, 13.3\u201328.0). Overall, 24.0% of participants had abnormal CFR, 34.6% had abnormal IMR, and 48.1% had a final diagnosis of invasively determined CMD. CSF was present in 23 participants (22.1%). The proportions of patients with CMD (56.5% versus 45.7%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.36), abnormal CFR (17.4% versus 25.9%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.40), and abnormal IMR (43.5% versus 32.1%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.31) were not different in patients with versus without CSF.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Among patients with ischemia with nonobstructive coronary artery, CSF was not associated with abnormal CFR, IMR, or either abnormal CFR or IMR. CSF is not a reliable angiographic surrogate of abnormal CFR or IMR as determined by invasive, wire-based physiology testing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT03537586.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.123.013902","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T18:15:06Z","timestamp":1712513706000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Visual Estimates of Coronary Slow Flow Are Not Associated With Invasive Wire-Based Diagnoses of Coronary Microvascular Dysfunction"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct03537586","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Kenneth L.","family":"Harkin","sequence":"first","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research (K.L.H., A.J., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethan","family":"Loftspring","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-6025","authenticated-orcid":true,"given":"William","family":"Beaty","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7133-9307","authenticated-orcid":true,"given":"Amanda","family":"Joa","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research (K.L.H., A.J., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Serrano-Gomez","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Farid","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana\u00efs","family":"Hausvater","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research (K.L.H., A.J., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-0655","authenticated-orcid":true,"given":"Harmony R.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research (K.L.H., A.J., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-2815","authenticated-orcid":true,"given":"Nathaniel R.","family":"Smilowitz","sequence":"additional","affiliation":[{"name":"Sarah Ross Soter Center for Women\u2019s Cardiovascular Research (K.L.H., A.J., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."},{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (E.L., W.B., C.S.-G., A.F., A.H., H.R.R., N.R.S.), New York University Grossman School of Medicine."},{"name":"Veterans Affairs New York Harbor Health Care System, Department of Medicine, Section of Cardiology (N.R.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907272"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2022.06.015"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.726562"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024534"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr331"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.09.047"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.040"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008126"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.06.044"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.122.012568"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.06.043"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001168"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.068"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198504043121435"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-12-0205"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000063121"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.93.5.879"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(72)90307-9"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/ac.67.5.2174134"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.18502\/jthc.v17i4.11608"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy185"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046791"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.50"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(03)00124-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.055"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027664"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707673"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.123.013902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:26Z","timestamp":1748552966000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.123.013902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.123.013902"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.123.013902","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}