{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:15:22Z","timestamp":1793330122563,"version":"4.5.0"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Evidence suggests that drug-coated balloons may benefit in-stent restenosis (ISR) treatment. However, the efficacy of new-generation sirolimus-coated balloon (SCB) compared with the latest generation drug-eluting stents (DESs) has not been studied in this setting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>All patients in the EASTBORNE (The All-Comers Sirolimus-Coated Balloon European Registry) and DEB-DRAGON (DEB vs Thin-DES in DES-ISR: Long Term Outcomes) registries undergoing percutaneous coronary intervention for DES-ISR were included in the study. The primary study end point was target lesion revascularization at 24 months. Secondary end points were major adverse cardiovascular events, all-cause death, myocardial infarction, and target vessel revascularization at 24 months. Our goal was to evaluate the efficacy and safety of SCB versus thin-struts DES in ISR at long-term follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 1545 patients with 1679 ISR lesions were included in the pooled analysis, of whom 621 (40.2%) patients with 621 lesions were treated with thin-strut DES and 924 (59.8%) patients with 1045 lesions were treated with SCB. The unmatched cohort showed no differences in the incidence of target lesion revascularization (10.8% versus 11.8%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.568); however, there was a trend toward lower rates of myocardial infarction (7.4% versus 5.0%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.062) and major adverse cardiovascular events (20.8% versus 17.1%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.072) in the SCB group. After propensity score matching (n=335 patients per group), there were no significant differences in the rates of target lesion revascularization (11.6% versus 11.8%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.329), target vessel revascularization (14.0% versus 13.1%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.822), myocardial infarction (7.2% versus 4.5%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.186), all-cause death (5.7% versus 4.2%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.476), and major adverse cardiovascular event (21.5% versus 17.6%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.242) between DES and SCB treatment.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients with ISR, angioplasty with SCB compared with thin-struts DES is associated with comparable rates of target lesion revascularization, target vessel revascularization, myocardial infarction, all-cause death, and major adverse cardiovascular events at 2 years.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014064","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T09:01:49Z","timestamp":1721898109000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Long-Term Outcomes Following Sirolimus-Coated Balloon or Drug-Eluting Stents for Treatment of In-Stent Restenosis"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-9496","authenticated-orcid":true,"given":"Wojciech","family":"Wa\u0144ha","sequence":"first","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland (W. Wa\u0144ha, P.P., T.Z.P., W. Wojakowski)."},{"name":"DCB Academy, Milano, Italy (W. Wa\u0144ha, S.I., B.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-6075","authenticated-orcid":true,"given":"Sylwia","family":"Iwa\u0144czyk","sequence":"additional","affiliation":[{"name":"DCB Academy, Milano, Italy (W. Wa\u0144ha, S.I., B.C.)."},{"name":"Department of Cardiology, Pozna\u0144 University of Medical Sciences, Poland (S.I., M.L., M. Grygier)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6591-1919","authenticated-orcid":true,"given":"Rafa\u0142","family":"Januszek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jagiellonian University Medical College, Krak\u00f3w, Poland (R.J., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-7563","authenticated-orcid":true,"given":"Rafa\u0142","family":"Wolny","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland (R.W., A.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-3560","authenticated-orcid":true,"given":"Brunon","family":"Tomasiewicz","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroc\u0142aw University Hospital, Poland (B.T., W.K., K.R., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6284-0820","authenticated-orcid":true,"given":"Wiktor","family":"Kuliczkowski","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroc\u0142aw University Hospital, Poland (B.T., W.K., K.R., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1699-739X","authenticated-orcid":true,"given":"Krzysztof","family":"Reczuch","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroc\u0142aw University Hospital, Poland (B.T., W.K., K.R., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Pawlus","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland (W. Wa\u0144ha, P.P., T.Z.P., W. Wojakowski)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz Z.","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland (W. Wa\u0144ha, P.P., T.Z.P., W. Wojakowski)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-5695","authenticated-orcid":true,"given":"\u0141ukasz","family":"Ku\u017ama","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Medical University of Bia\u0142ystok, Poland (L.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-0475","authenticated-orcid":true,"given":"Piotr","family":"Kubler","sequence":"additional","affiliation":[{"name":"Institute of Heart Diseases, Wroc\u0142aw University Hospital, Poland (B.T., W.K., K.R., P.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-9730","authenticated-orcid":true,"given":"Piotr","family":"Niezgoda","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland (P.N., J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8250-754X","authenticated-orcid":true,"given":"Jacek","family":"Kubica","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Internal Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland (P.N., J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9041-3313","authenticated-orcid":true,"given":"Robert J.","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland (R.J.G., T.F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz F.","family":"Paw\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Invasive Cardiology, Center of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of Interior and Administration, Warsaw, Poland (R.J.G., T.F.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"G\u0105sior","sequence":"additional","affiliation":[{"name":"Third Department of Cardiology, Medical University of Silesia, Zabrze, Poland (M. G\u0105sior)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2555-593X","authenticated-orcid":true,"given":"Mi\u0142osz","family":"Jaguszewski","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Medical University of Gda\u0144sk, Poland (M.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1151-8385","authenticated-orcid":true,"given":"Maciej","family":"Wybraniec","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Poland (M. Wybraniec)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-2047","authenticated-orcid":true,"given":"Adam","family":"Witkowski","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland (R.W., A.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariusz","family":"Kowalewski","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery and Transplantology, National Medical Institute of the Ministry of Interior and Administration, Warsaw, Poland (M.K.)."},{"name":"Cardio-Thoracic Surgery Department, Heart and Vascular Centre, Maastricht University Medical Centre (MUMC), Cardiovascular Research Centre Maastricht (CARIM), the Netherlands (M.K.)."},{"name":"Department for the Treatment and Study of Cardiothoracic Diseases and Cardiothoracic Transplantation, IRCCS-ISMETT, Palermo, Italy (M.K.)."},{"name":"Thoracic Research Centre, Collegium Medicum Nicolaus Copernicus University, Innovative Medical Forum, Bydgoszcz, Poland (M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":true,"given":"Fabrizio","family":"D\u2019Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cardiovascular and Thoracic Department, \u201cCitta della Salute e della Scienza\u201d Hospital, Turin, Italy (F.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2926-9428","authenticated-orcid":true,"given":"Antonio","family":"Greco","sequence":"additional","affiliation":[{"name":"A.O.U. 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