{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:16:24Z","timestamp":1791861384896,"version":"4.3.4"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Clot-in-transit is associated with high mortality, but optimal management strategies remain uncertain. The aim of this study was to compare the outcomes of different treatment strategies in patients with clot-in-transit.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This is a retrospective study of patients with documented clot-in-transit in the right heart on echocardiography across 2 institutions between January 2020 and October 2023. The primary outcome was a composite of in-hospital mortality, resuscitated cardiac arrest, or hemodynamic decompensation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Among 35 patients included in the study, 10 patients (28.6%) received anticoagulation alone and 2 patients (5.7%) received systemic thrombolysis, while 23 patients (65.7%) underwent catheter-based therapy (CBT; 22 mechanical thrombectomy and 1 catheter-directed thrombolysis). Over a median follow-up of 30 days, 9 patients (25.7%) experienced the primary composite outcome. Compared with anticoagulation alone, patients who received CBT or systemic thrombolysis had significantly lower rates of the primary composite outcome (12% versus 60%; log-rank\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001; hazard ratio, 0.13 [95% CI, 0.03\u20130.54];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.005) including a lower rate of death (8% versus 50%; hazard ratio, 0.10 [95% CI, 0.02\u20130.55];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.008), resuscitated cardiac arrest (4% versus 30%; hazard ratio, 0.12 [95% CI, 0.01\u20131.15];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.067), or hemodynamic deterioration (4% versus 30%; hazard ratio, 0.12 [95% CI, 0.01\u20131.15];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.067).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In this study of CBT in patients with clot-in-transit, CBT or systemic thrombolysis was associated with a significantly lower rate of adverse clinical outcomes, including a lower rate of death compared with anticoagulation alone driven by the CBT group. CBT has the potential to improve outcomes. Further large-scale studies are needed to test these associations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014109","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T09:01:10Z","timestamp":1717664470000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Comparing Management Strategies in Patients With Clot-in-Transit"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-6094","authenticated-orcid":true,"given":"Robert S.","family":"Zhang","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2263-9297","authenticated-orcid":true,"given":"Eugene","family":"Yuriditsky","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7466-8213","authenticated-orcid":true,"given":"Peter","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine (P.Z., E.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Elbaum","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Medicine (P.Z., E.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-4448","authenticated-orcid":true,"given":"Muhammad H.","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Department of Cardiology, DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX (M.H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu","family":"Postelnicu","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine (R.P., N.E.A.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy E.","family":"Amoroso","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Critical Care and Sleep Medicine (R.P., N.E.A.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2915-5658","authenticated-orcid":true,"given":"Thomas S.","family":"Maldonado","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Department of Surgery, New York University School of Medicine (T.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamed","family":"Saric","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos L.","family":"Alviar","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-5434","authenticated-orcid":true,"given":"James M.","family":"Horowitz","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (R.S.Z., E.Y., L.E., M.S., C.L.A., J.M.H., S.B.), New York 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