{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:41:47Z","timestamp":1792698107876,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Lipid content in untreated nonobstructive coronary artery lesions is associated with adverse clinical outcomes, and residual in-stent or stent edge lipid may worsen outcomes after percutaneous coronary intervention (PCI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Near-infrared spectroscopy-intravascular ultrasound was performed before and after PCI in patients with myocardial infarction. We evaluated the impact of lipid assessed by near-infrared spectroscopy (maximal lipid core burden index over 4 mm [maxLCBI\n              <jats:sub>4mm<\/jats:sub>\n              ]) along with intravascular ultrasound information including residual plaque burden on in-stent or edge-related major adverse cardiac events (MACE) in de novo PCI-treated culprit coronary artery lesions. The primary end point was culprit lesion-related MACE (CL-MACE), defined as cardiac death, myocardial infarction, or unstable or progressive angina either requiring revascularization or with rapid lesion progression and classified as in-stent or stent edge\u2013related.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              During a median follow-up of 3.8 years, 25 CL-MACE (11 stent edge\u2013related, 13 in-stent, and 1 in-lesion without a stent) occurred in 1041 PCI-treated lesions in 768 patients. Pre-PCI or post-PCI measures of lipid content were not related to in-stent CL-MACE. However, stent edge\u2013related CL-MACE was increased if both the post-PCI stent edge maxLCBI\n              <jats:sub>4mm<\/jats:sub>\n              was greater than the upper quartile (108.7) and the stent edge plaque burden was &gt;50% (adjusted odds ratio, 4.11 [95% CI, 1.12\u201315.2];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.03).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In PROSPECT II (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), CL stent implantation leaving behind greater stent edge\u2013related lipid and uncovered plaque burden was associated with an increased risk of stent edge\u2013related CL-MACE during follow-up. In contrast, CL lipid content was not related to in-stent CL-MACE.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique identifier: NCT02171065.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014215","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T11:43:57Z","timestamp":1727264637000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Lipidic Plaque on In-Stent and Stent Edge\u2013Related Events After PCI in Myocardial Infarction: A PROSPECT II Substudy"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"nct02171065","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0819-5792","authenticated-orcid":true,"given":"Lars","family":"Kj\u00f8ller-Hansen","sequence":"first","affiliation":[{"name":"Zealand University Hospital, Roskilde, Denmark (L.K.-H., H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8447","authenticated-orcid":true,"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center, New York, NY (A.M.)."},{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M. Matsumura, G.S.M., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-3733","authenticated-orcid":true,"given":"Henning","family":"Kelb\u00e6k","sequence":"additional","affiliation":[{"name":"Zealand University Hospital, Roskilde, Denmark (L.K.-H., H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0247","authenticated-orcid":true,"given":"Mitsuaki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M. Matsumura, G.S.M., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4310-6433","authenticated-orcid":true,"given":"Michael","family":"Maeng","sequence":"additional","affiliation":[{"name":"Aarhus University Hospital and Aarhus University, Denmark (M. Maeng)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5436-9194","authenticated-orcid":true,"given":"Thomas","family":"Engstr\u00f8m","sequence":"additional","affiliation":[{"name":"Rigshospitalet, University of Copenhagen, Denmark (T.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-345X","authenticated-orcid":true,"given":"Ole","family":"Fr\u00f6bert","sequence":"additional","affiliation":[{"name":"\u00d6rebro University, Aarhus University, Denmark (O.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-8745","authenticated-orcid":true,"given":"Jonas","family":"Persson","sequence":"additional","affiliation":[{"name":"Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden (J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-4554","authenticated-orcid":true,"given":"Rune","family":"Wiseth","sequence":"additional","affiliation":[{"name":"St. Olavs University Hospital, Norway (R.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-0499","authenticated-orcid":true,"given":"Alf Inge","family":"Larsen","sequence":"additional","affiliation":[{"name":"Stavanger University Hospital, Norway (A.I.L.)."},{"name":"University of Bergen, Norway (A.I.L., J.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4838-2429","authenticated-orcid":true,"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[{"name":"Odense University Hospital, Denmark (L.O.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Erik","family":"Nordrehaug","sequence":"additional","affiliation":[{"name":"University of Bergen, Norway (A.I.L., J.E.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-8621","authenticated-orcid":true,"given":"Elmir","family":"Omerovic","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital, Gothenburg, Sweden (E.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9402-7404","authenticated-orcid":true,"given":"Claes","family":"Held","sequence":"additional","affiliation":[{"name":"Uppsala University and Uppsala Clinical Research Center, Uppsala, Sweden (C.H., S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-9736","authenticated-orcid":true,"given":"Stefan","family":"James","sequence":"additional","affiliation":[{"name":"Uppsala University and Uppsala Clinical Research Center, Uppsala, Sweden (C.H., S.J.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-8705","authenticated-orcid":true,"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M. 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