{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:16:31Z","timestamp":1767852991018,"version":"3.49.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>While initial data for transcatheter aortic valve replacement (TAVR) in aortic stenosis patients with mitral stenosis (MS) suggested a poor short-term prognosis, outcomes for contemporary balloon-expandable valves remain unknown. The aim of this retrospective multicenter registry study was to compare the potential impact of MS on TAVR outcomes with balloon-expandable valves.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>\n              Society of Thoracic Surgeons\/American College of Cardiology Transcatheter Valve Therapies Registry and Centers for Medicare &amp; Medicaid Services claims data were used to obtain a cohort of 327\u2005925 patients who underwent TAVR with current balloon-expandable valves (SAPIEN 3, SAPIEN 3 Ultra, or SAPIEN 3 Ultra Resilia) between June 2015 and December 2022 across 791 sites. Severe MS (defined as &gt;10 mm\u2005Hg mean gradient or &lt;1.5 cm\n              <jats:sup>2<\/jats:sup>\n              area) was compared with mild or less MS (defined as &lt;5 mm\u2005Hg mean gradient and &gt;2 cm\n              <jats:sup>2<\/jats:sup>\n              area) using propensity matching to minimize confounding variables.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Patients with severe MS (n=8500; 2.6%) had a higher number of comorbid conditions, Society of Thoracic Surgeons risk scores, and were more often women than patients with mild or less MS at the time of index TAVR. While patients with severe MS had worse outcomes at 30 days, when propensity-matched, patients exhibited similar 30-day rates of death (3.2% versus 3.0%), stroke (2.4% versus 2.2%), major vascular complications (1.6% versus 1.6%), device implant success (98.9% versus 99.2%), and new dialysis (0.7% versus 0.5%), with higher rates of pacemaker implantation (11.3% versus 9.4%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). By 1 year, there was no difference in the change in the KCCQ (Kansas City Cardiomyopathy Questionnaire) overall score from baseline to 1 year (30.7\u00b127.0 versus 31.9\u00b127.0;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.07). By 3 years, an increase in the mortality rate (45.1% versus 40.9%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) of patients with severe MS was observed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>MS in isolation is not associated with worsened short-term outcomes among patients undergoing contemporary TAVR with balloon-expandable valves.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014216","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T10:03:49Z","timestamp":1732269829000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Contemporary Outcomes of TAVR Using a Balloon-Expandable Valve in Patients With Severe Mitral Stenosis: Insights From the Transcatheter Valve Therapies Registry"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4413-5439","authenticated-orcid":true,"given":"Anirudh","family":"Kumar","sequence":"first","affiliation":[{"name":"Division of Cardiology, Northwestern Medicine Central DuPage Hospital, Winfield, IL (A.K., I.N.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran N.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern Medicine Central DuPage Hospital, Winfield, IL (A.K., I.N.A.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6707-8414","authenticated-orcid":true,"given":"James D.","family":"Flaherty","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Northwestern University, Evanston, IL (J.D.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6579-6244","authenticated-orcid":true,"given":"Vinayak","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Rochester, MN (V.N., M.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0151-5471","authenticated-orcid":true,"given":"Chetan P.","family":"Huded","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (C.P.H.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8234-3135","authenticated-orcid":true,"given":"Grant W.","family":"Reed","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (G.W.R., R.P., A.K., S.R.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-7426","authenticated-orcid":true,"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (G.W.R., R.P., A.K., S.R.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Rassi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Kaiser Permanente San Francisco Medical Center, CA (A.N.R.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-3876","authenticated-orcid":true,"given":"Sachin S.","family":"Goel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Houston Methodist DeBakey Heart and Vascular Center, TX (S.S.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-358X","authenticated-orcid":true,"given":"Hani","family":"Jneid","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Texas Medical Branch, Galveston (H.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-2327","authenticated-orcid":true,"given":"James M.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, University of Washington, Seattle (J.M.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":true,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mayo Clinic, Rochester, MN (V.N., M.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8448-8880","authenticated-orcid":true,"given":"Firas","family":"Zahr","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Oregon Health and Science University, Portland (F.Z.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-7955","authenticated-orcid":true,"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (G.W.R., R.P., A.K., S.R.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":true,"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Heart, Vascular and Thoracic Institute, Cleveland Clinic, OH (G.W.R., R.P., A.K., S.R.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw229"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/IMI.0000000000000028"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezy205"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60290-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.113.003885"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.573"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.05.065"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.01.245"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy834"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2022.05.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2019-0084"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.120.009407"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2021.07.030"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.060"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00531-3"},{"key":"e_1_3_3_20_2","doi-asserted-by":"crossref","DOI":"10.1201\/9781439821862","volume-title":"Analysis of Incomplete Multivariate Data","author":"Schafer JL","year":"1997","unstructured":"Schafer JL. Analysis of Incomplete Multivariate Data. Chapman & Hall; 1997."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2307\/2337177"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.946533"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.08.024"},{"key":"e_1_3_3_24_2","unstructured":"Centers for Medicare & Medicaid Services. National Coverage Determination (NCD) for Transcatheter Aortic Valve Replacement (TAVR) (20.32). 2019. Accessed March 27 2024. https:\/\/www.cms.gov\/medicare-coverage-database\/details\/ncd-details.aspx?NCDid=355"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.120.007187"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.02.054"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.09.037"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.119.040679"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.124.014216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:28Z","timestamp":1748552968000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.124.014216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.124.014216"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.124.014216","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}