{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:51:07Z","timestamp":1780995067883,"version":"3.54.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Transcatheter aortic valve replacement (TAVR) pushes aside the diseased native aortic valve and creates a native neo-sinus bordered by the aortic root wall and the displaced native valve. There are limited data on the progression of native valve disease post-TAVR and no previous analysis of the native neo-sinus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Native aortic valves and native neo-sinus explants obtained post-TAVR were evaluated histologically (hematoxylin and eosin, Movat pentachrome, and Martius Scarlet Blue stains) and by immunohistochemistry (TGF-\u03b21 [transforming growth factor-beta 1], FAP [fibroblast activation protein], and ALP [alkaline phosphatase]) to assess disease mechanisms.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Native aortic valves were obtained from 20 patients from 0 to 2583 days (7.08 years) post-TAVR. Native leaflets showed persistent calcific aortic stenosis-like disease activity with positivity for ALP and FAP. Native valve remodeling was observed as changes in architecture evident in explants &gt;1.5 years, which was observed as crumpling of the leaflets. Disease activity was also present in native neo-sinuses with transcatheter heart valve implant durations &gt;1 year with positive staining for TGF-\u03b21, FAP, and ALP. Extensive native neo-sinus remodeling occurred with replacement and filling-in of this space with contiguous extracellular matrix, calcific deposits, and microvessels.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Following TAVR, there is ongoing calcific aortic stenosis-like disease with architectural changes to native leaflets and extensive remodeling of the native neo-sinus, evidenced by replacement and contiguous filling-in of the native neo-sinus blood pool space with increasing implant duration. The dynamic nature of these tissues has potential implications for neo-sinus flow, valve degeneration, and re-intervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014379","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T19:00:58Z","timestamp":1734462058000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Native Valve and Native Neo-Sinus Remodeling Following Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0830-1521","authenticated-orcid":true,"given":"Joshua","family":"Yoon","sequence":"first","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacina","family":"Gill","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Department of Medicine, University of British Columbia, Experimental Medicine Program, Vancouver, Canada (H.G., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Jelisejevas","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Centre for Cardiovascular Innovation, St Paul\u2019s and Vancouver General Hospital, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."},{"name":"Centre for Heart Valve Innovation and Division of Cardiology, St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Althea","family":"Lai","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6099-0753","authenticated-orcid":true,"given":"Jaffar M.","family":"Khan","sequence":"additional","affiliation":[{"name":"St. Francis Hospital and Heart Centre, Roslyn, NY (J.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"Payne","sequence":"additional","affiliation":[{"name":"University of Northern British Columbia, Prince George, Canada (G.W.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Centre for Cardiovascular Innovation, St Paul\u2019s and Vancouver General Hospital, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."},{"name":"Centre for Heart Valve Innovation and Division of Cardiology, St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janarthanan","family":"Sathananthan","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Centre for Cardiovascular Innovation, St Paul\u2019s and Vancouver General Hospital, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."},{"name":"Centre for Heart Valve Innovation and Division of Cardiology, St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-827X","authenticated-orcid":true,"given":"Michael A.","family":"Seidman","sequence":"additional","affiliation":[{"name":"Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada (M.A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5524-5844","authenticated-orcid":true,"given":"David","family":"Meier","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Department of Cardiology, Lausanne University Hospital and University of Lausanne, Switzerland (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-5730","authenticated-orcid":true,"given":"Stephanie L.","family":"Sellers","sequence":"additional","affiliation":[{"name":"Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.)."},{"name":"Department of Medicine, University of British Columbia, Experimental Medicine Program, Vancouver, Canada (H.G., S.L.S.)."},{"name":"Centre for Cardiovascular Innovation, St Paul\u2019s and Vancouver General Hospital, British Columbia, Canada (J.J., J.G.W., J.S., S.L.S.)."},{"name":"Centre for Heart Valve Innovation and Division of Cardiology, St. Paul\u2019s Hospital, Vancouver, British Columbia, Canada (J.J., J.G.W., 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