{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:20:48Z","timestamp":1784575248606,"version":"3.55.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The 1.5 mm Baby J hydrophilic narrow J-tipped wire is a development of the standard 0.035\u201d 3-mm J-tipped peripheral guidewire, designed to improve efficiency of transradial coronary procedures by safely navigating small caliber radial arteries to the aorta. There is currently a lack of evidence comparing the procedural success and safety of different peripheral guidewires used in transradial cardiac procedures. We compared the efficacy and safety of a narrow J-tipped hydrophilic 0.035\u201d wire (intervention, Radifocus Baby J guidewire; TERUMO Co, Tokyo, Japan) versus a standard fixed-core 0.035\u201d J wire (control).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>Investigator-initiated, blinded, Australian, multicenter randomized trial in patients undergoing clinically indicated coronary angiography or percutaneous coronary intervention. Patients were randomized 1:1 to use either the control guidewire or the intervention guidewire. The primary end point (technical success) was defined as gaining aortic root access with the randomized guidewire.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              In all, 330 patients were randomized between October 2022 and June 2023 (median age was 69 years, 36% were female, and body mass index was 29 kg\/m\n              <jats:sup>2<\/jats:sup>\n              ). The primary end point was achieved more frequently in the intervention group (96% versus 84%; absolute risk reduction 12% [95% CI, 5.7\u201318.3];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). Women assigned to the control wire experienced a higher failure rate compared with men (31% versus 8% in men;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001). Fluoroscopy time was significantly lower in the Baby J group (median, 344 versus 491 seconds;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.024). The main mechanisms of failure using the control wire were radial artery spasm (15\/26; 57%) and subclavian tortuosity (5\/26; 19.2%). There were no differences in overall procedure times, major adverse cardiovascular events, or vascular complications between guidewires.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>A narrow 1.5 mm J-tipped hydrophilic guidewire resulted in greater technical success and reduced fluoroscopy time compared with the standard 3-mm J-tipped nonhydrophilic guidewire. The guidewire is safe and demonstrated key incremental benefits for the transradial approach, particularly in women.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.anzctr.org.au\/\">https:\/\/www.anzctr.org.au\/<\/jats:ext-link>\n              ; Unique identifier: ACTRN12622001557729.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014529","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T07:00:46Z","timestamp":1725087646000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Enhancing Guidewire Efficacy for Transradial Access: The EAGER Randomized Controlled Trial"],"prefix":"10.1161","volume":"17","clinical-trial-number":[{"clinical-trial-number":"actrn12622001557729","registry":"10.18810\/anzctr"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-9137","authenticated-orcid":true,"given":"Adam C.","family":"Bland","sequence":"first","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Meere","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-1801","authenticated-orcid":true,"given":"Philopatir","family":"Mikhail","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3482-8159","authenticated-orcid":true,"given":"Eunice","family":"Chuah","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8563-1353","authenticated-orcid":true,"given":"Eleanor","family":"Redwood","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-4503","authenticated-orcid":true,"given":"David","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiology Department, John Hunter Hospital, Hunter New England Local Health District, Newcastle, Australia (D.F., N.C., A.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicklas","family":"Howden","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7582-5611","authenticated-orcid":true,"given":"Adam","family":"Perkovic","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9473-2012","authenticated-orcid":true,"given":"Samantha L.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2379-6239","authenticated-orcid":true,"given":"Amy","family":"Kelty","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Kull","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hill","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Spina","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Sarathy","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin","family":"May","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3542-8638","authenticated-orcid":true,"given":"Michael","family":"Parkinson","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ishak","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Collins","sequence":"additional","affiliation":[{"name":"Cardiology Department, John Hunter Hospital, Hunter New England Local Health District, Newcastle, Australia (D.F., N.C., A.B.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3919-5269","authenticated-orcid":true,"given":"Andrew","family":"Boyle","sequence":"additional","affiliation":[{"name":"Cardiology Department, John Hunter Hospital, Hunter New England Local Health District, Newcastle, Australia (D.F., N.C., A.B.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maged","family":"William","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6156-9012","authenticated-orcid":true,"given":"Prajith","family":"Jeyaprakash","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4009-6652","authenticated-orcid":true,"given":"Tom J.","family":"Ford","sequence":"additional","affiliation":[{"name":"Cardiology Department, Gosford Hospital, Central Coast Local Health District, Australia (A.C.B., W.M., P.M., E.C., E.R., N.H., A.P., S.L.S., A.K., T.K., A.H., R.S., K.S., A.M., M.P., M.I., M.W., P.J., T.J.F.)."},{"name":"School of Medicine and Public Health, The University of Newcastle, Australia (A.C.B., S.L.S., N.C., A.B., M.W., T.J.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.08.023"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22978"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-018534"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq102"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.12659\/msm.939429"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.10586"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.150474"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2021.12.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22448"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.31579\/2641-0419\/239"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2024.03.006"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2007.09.017"},{"key":"e_1_3_3_16_2","first-page":"159","article-title":"Prevention and management of radial artery spasm.","volume":"18","author":"Kiemeneij F","year":"2006","unstructured":"Kiemeneij F. Prevention and management of radial artery spasm. J Invasive Cardiol. 2006;18:159\u2013160.","journal-title":"J Invasive Cardiol"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03042-z"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v12.i1.26"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.124.014529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:20Z","timestamp":1748552960000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.124.014529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.124.014529"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.124.014529","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}