{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:08:46Z","timestamp":1792195726395,"version":"4.4.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The optimal duration of dual antiplatelet therapy (DAPT) after complex percutaneous coronary intervention (PCI) remains unclear. We aim to investigate the efficacy and safety of 3 to 6 months of DAPT over 12 months after complex PCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>A post hoc analysis of the HOST-IDEA (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-Coronary Intervention With Next-Generation Drug-Eluting Stent Platforms and Abbreviated Dual Antiplatelet Therapy) randomized trial which enrolled patients undergoing PCI with third-generation drug-eluting stents was performed. Complex PCI was defined by any of the following: \u22653 stents implanted, \u22653 lesions treated, bifurcation PCI with 2-stenting, total stent length \u226560 mm, left main PCI, or heavy calcification. The major end points were target lesion failure, a composite of cardiac death, target vessel myocardial infarction, and clinically driven target lesion revascularization for ischemic outcomes, and major bleeding, defined as BARC (Bleeding Academic Research Consortium) type 3 or 5, for bleeding outcomes at 12 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              Among 1992 patients, 624 underwent complex PCI. The complex PCI group had clinical features associated with high bleeding risk. A shortened DAPT duration did not increase the risk of target lesion failure, with hazard ratios of 0.818 (95% CI, 0.403\u20131.659) for the complex PCI group and 1.282 (95% CI, 0.506\u20133.249) for the noncomplex PCI group (\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.451). Conversely, it decreased the risk of major bleeding in the complex PCI group (hazard ratio, 0.269 [95% CI, 0.075\u20130.965]), but not in the noncomplex PCI group (hazard ratio, 1.534 [95% CI, 0.627\u20133.754], showing a significant interaction;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              <jats:sub>interaction<\/jats:sub>\n              =0.029).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>In patients undergoing complex PCI with a third-generation drug-eluting stent, a 3- to 6-month duration of DAPT was associated with a reduced risk of bleeding without an increased risk of ischemic events compared with 12-month DAPT.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              ; Unique Identifier: NCT02601157.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014623","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T09:12:29Z","timestamp":1743412349000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Short-Term DAPT After Complex PCI With Third-Generation DES: A Post Hoc Analysis of the HOST-IDEA Trial"],"prefix":"10.1161","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct02601157","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-0747","authenticated-orcid":true,"given":"Jung-Kyu","family":"Han","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keehwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Division of Cardiology, Department of Medicine, Gangneung Asan Hospital, South Korea (K.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-4146","authenticated-orcid":true,"given":"Sang-Hyeon","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, Daejeon Eulji Medical Center, Eulji University School of Medicine, Republic of Korea (Sang-Hyun Park)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-3930","authenticated-orcid":true,"given":"Seokhun","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doyeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeehoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-2351","authenticated-orcid":true,"given":"Han-Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-4432","authenticated-orcid":true,"given":"Kyung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3500-1746","authenticated-orcid":true,"given":"Hyun-Jae","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-3348","authenticated-orcid":true,"given":"Bon-Kwon","family":"Koo","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."},{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1915","authenticated-orcid":true,"given":"Seung-Ho","family":"Hur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Republic of Korea (S.-H.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1264-9870","authenticated-orcid":true,"given":"Weon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Seoul, Republic of Korea (W.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-3487","authenticated-orcid":true,"given":"Sang-Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Seoul National University Hospital, Republic of Korea (J.-K.H., K.L., Sang-Hyeon Park, S.Y., D.H., J.K., H.-M.Y., K.W.P., H.-J.K., B.-K.K., H.-S.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7315-7557","authenticated-orcid":true,"given":"Seung Hwan","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea (S.H.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-1582","authenticated-orcid":true,"given":"Sang-Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Seoul National University, Republic of Korea (J.-K.H., H.-M.Y., K.W.P., H.-J.K., B.-K.K., S.-H.K., H.-S.K.)."},{"name":"Division of Cardiology, Department of Internal Medicine, Seoul National University Boramae Medical Center, Republic of Korea (S.-H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-3598","authenticated-orcid":true,"given":"Yong Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Republic of Korea 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