{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T20:12:03Z","timestamp":1775851923806,"version":"3.50.1"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","funder":[{"name":"NIH","award":["R01AG068633"],"award-info":[{"award-number":["R01AG068633"]}]},{"name":"NIH","award":["R01AG082991"],"award-info":[{"award-number":["R01AG082991"]}]},{"name":"NIH","award":["R01MD013913"],"award-info":[{"award-number":["R01MD013913"]}]},{"name":"NIH","award":["R03AG073993"],"award-info":[{"award-number":["R03AG073993"]}]}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Percutaneous microaxial ventricular assist devices (pVADs) have the potential to reduce mortality of patients with cardiogenic shock (CS). However, the association between the distribution of pVAD-performing centers and outcomes of CS has not been explored.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>This observational study included Medicare fee-for-service beneficiaries aged 65 to 99 years treated with pVAD for CS from 2016 to 2020. It examined the associations between patient outcomes and 2 exposure variables: hospitals\u2019 procedure volumes of pVAD and patient-hospital distances (in quintiles [Qn]). We developed Cox proportional hazards regression for 180-day mortality and heart failure readmission rates, and multivariable logistic regression for in-hospital outcomes, adjusting for patient demographics, comorbidities, concomitant treatments, and hospital characteristics, including CS volume, teaching status, and the ability to perform extracorporeal membrane oxygenation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              A total of 6637 patients with CS underwent pVAD at 1041 hospitals, with the annualized hospital volume ranging widely from 0.3 to 55.6 cases\/year. Patients treated at higher-volume centers experienced lower 180-day mortality compared with those treated at lower-volume centers (Qn1=reference; Qn2: adjusted hazard ratio [aHR], 0.88 [95% CI, 0.79\u20130.97]; Qn3: aHR, 0.88 [95% CI, 0.79\u20130.98]; Qn4: aHR, 0.88 [95% CI, 0.78\u20130.99]; Qn5: aHR, 0.84 [95% CI, 0.74\u20130.95];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              for trend, 0.026), while we found no evidence that patient-hospital distances were associated with mortality (Qn1=reference; Qn2: aHR, 0.99 [95% CI, 0.89\u20131.09]; Qn3: aHR, 0.94 [95% CI, 0.85\u20131.04]; Qn4: aHR, 1.01 [95% CI, 0.92\u20131.11]; Qn5: aHR, 0.91 [95% CI, 0.82\u20131.01];\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              for trend, 0.160). We found no evidence that the hospital volume and patient-hospital distances were associated with in-hospital bleeding, intracranial hemorrhage, or renal replacement therapy initiation.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Hospital volume was more strongly associated with mortality than patient-hospital distances, suggesting that rational distribution of pVAD-performing centers while ensuring adequate procedure volumes may optimize patient mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014738","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T14:50:12Z","timestamp":1730213412000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Impacts of Hospital Volume and Patient-Hospital Distances on Outcomes of Older Adults Receiving Percutaneous Microaxial Ventricular Assist Devices for Cardiogenic Shock"],"prefix":"10.1161","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8781-0329","authenticated-orcid":true,"given":"Atsuyuki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Medicine, Mount Sinai Morningside and West, Icahn School of Medicine at Mount Sinai, New York, NY (A.W.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2852-2946","authenticated-orcid":true,"given":"Yoshihisa","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Real-World Evidence, The University of Tokyo, Japan (Y.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki A.","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Emory University School of Medicine, Atlanta, GA (H.A.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4238-0171","authenticated-orcid":true,"given":"Hiroshi","family":"Gotanda","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, CA (H.G.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6366-2859","authenticated-orcid":true,"given":"Jacob C.","family":"Jentzer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (J.C.J.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8302-6796","authenticated-orcid":true,"given":"Navin K.","family":"Kapur","sequence":"additional","affiliation":[{"name":"The Cardiovascular Center, Tufts Medical Center, Boston, MA (N.K.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9476-6466","authenticated-orcid":true,"given":"Ulrich P.","family":"Jorde","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY (U.P.J., T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1937-4833","authenticated-orcid":true,"given":"Yusuke","family":"Tsugawa","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine at The University of California, Los Angeles (Y.T.)."},{"name":"Department of Health Policy and Management, The University of California, Los Angeles Fielding School of Public Health (Y.T.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-8366","authenticated-orcid":true,"given":"Toshiki","family":"Kuno","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY (U.P.J., T.K.)."},{"name":"Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston (T.K.)."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021061"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2019.03.004"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-020-01781-z"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208410"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307227"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066179"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2312572"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.2735"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.044007"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.034645"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.014"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000375"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa012337"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000233"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.028"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61069-2"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.047654"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2705-1"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.1643"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.7875"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjqs-2018-008087"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004623"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.05.012"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04385-x"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1195"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199507000-00025"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032607"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13180"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.044"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040931"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.031"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2023.09.009"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10411011"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.017719"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02035"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx104"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872616683526"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.027"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-021-10140-7"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2024.07.014"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.124.014738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T21:09:31Z","timestamp":1748552971000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.124.014738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.124.014738"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.124.014738","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}