{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:27:11Z","timestamp":1772832431280,"version":"3.50.1"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>The impact of age on outcomes after revascularization for chronic limb-threatening ischemia has not been studied in a prospective trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>A total of 1780 patients were grouped into age quartiles (\u226455 years, 55&lt; age \u226465 years, 65&lt; age \u226475 years, and &gt;75 years) and by type of revascularization (open bypass or endovascular). The primary outcome was major adverse limb events (MALE) or death, and the secondary outcomes were above-ankle amputation, reintervention, and major adverse cardiovascular events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>Death and major adverse cardiovascular events were significantly higher in the oldest quartile (&gt;75 years), whereas MALE and above-ankle amputation were highest in the youngest cohort (\u226455 years). Younger patients (\u226455 years) had the lowest adjusted risk of MALE or all-cause death with open bypass compared with endovascular revascularization. There was no difference in MALE or all-cause death by treatment strategy in patients &gt;75 years of age.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Older age was associated with the highest risks of death and major adverse cardiovascular events and the lowest risks of MALE and above-ankle amputation among patients enrolled in BEST-CLI (Best Endovascular Versus Best Surgical Therapy in Patients With Chronic Limb-Threatening Ischemia). Age also had a differential impact by revascularization strategy: youngest patients had the lowest risk of MALE and all-cause death with bypass surgery compared with endovascular revascularization, while there was no difference among those &gt;75 years. These data should be used to facilitate shared decision-making in patients with chronic limb-threatening ischemia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>REGISTRATION:<\/jats:title>\n            <jats:p>\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/biolincc.nhlbi.nih.gov\/studies\/best_cli\/\">https:\/\/biolincc.nhlbi.nih.gov\/studies\/best_cli\/<\/jats:ext-link>\n              ; Unique identifier: HLB02932424a.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014833","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T18:00:21Z","timestamp":1750183221000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Age-Related Outcomes After Revascularization for Chronic Limb-Threatening Ischemia: An Analysis of BEST-CLI"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8244-8236","authenticated-orcid":true,"given":"Khanjan B.","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville (K.B.S.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-3104","authenticated-orcid":true,"given":"Hanaa","family":"Aridi","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis (H.A., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2817-0875","authenticated-orcid":true,"given":"Michael D.","family":"Dake","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, University of Arizona Health Sciences, Tucson (M.D.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe","family":"Doros","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Boston University, School of Public Health, MA (G.D.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7231-4189","authenticated-orcid":true,"given":"Alik","family":"Farber","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, MA (A.F.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2470-7978","authenticated-orcid":true,"given":"Matthew T.","family":"Menard","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Brigham and Women\u2019s Hospital (M.T.M., M.B.S.), Harvard Medical School, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-2832","authenticated-orcid":true,"given":"Raghu","family":"Motaganahalli","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Indiana University School of Medicine, Indianapolis (H.A., R.M.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassius","family":"Ochoa Chaar","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT (C.O.C.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5633-6983","authenticated-orcid":true,"given":"Kenneth","family":"Rosenfield","sequence":"additional","affiliation":[{"name":"Section of Vascular Medicine and Intervention Massachusetts General Hospital (K.R.), Harvard Medical School, Boston."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8128-3203","authenticated-orcid":true,"given":"Salvatore T.","family":"Scali","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville (S.T.S., S.K.S., G.R.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6474-1455","authenticated-orcid":true,"given":"Samir K.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery and Endovascular Therapy, University of Florida, Gainesville (S.T.S., S.K.S., G.R.U.)."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-6806","authenticated-orcid":true,"given":"Michael B.","family":"Strong","sequence":"additional","affiliation":[{"name":"Division of Vascular and Endovascular Surgery, Brigham and Women\u2019s Hospital (M.T.M., M.B.S.), 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