{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:46:10Z","timestamp":1793817970322,"version":"4.6.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Myocardial injury detected after percutaneous coronary intervention (PCI) is associated with increased mortality. Predictors of post-PCI myocardial injury are not well established. The long-term prognostic relevance of post-PCI myocardial injury remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Consecutive adults aged \u226518 years with stable ischemic heart disease who underwent elective PCI at NYU Langone Health between 2011 and 2020 were included in a retrospective, observational study. Patients with acute myocardial infarction or creatinine kinase myocardial band (CKMB) or troponin concentrations &gt;99% of the upper reference limit before PCI were excluded. All patients had routine measurement of CKMB concentrations at 1 and 3 hours post-PCI. Post-PCI myocardial injury was defined as a peak CKMB concentration &gt;99% upper reference limit. Linear regression models were used to identify clinical factors associated with post-PCI myocardial injury. Cox proportional hazard models were generated to evaluate relationships between post-PCI myocardial injury and all-cause mortality at long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 10\u2005807 patients undergoing elective PCI, the median age was 67 years (interquartile range, 15.6), and 24.9% were of female sex. Post-PCI myocardial injury occurred in 1813 (16.8%) patients. Myocardial injury was less common among female than male patients (14.1% versus 17.7%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Older age, longer lesion lengths, multivessel PCI, severe coronary calcification, and thrombectomy device use were independently associated with post-PCI myocardial injury with CKMB levels \u226599% upper reference limit. Over 46\u2005071 patient-years of follow-up (mean 4.3 years), 472 patients died (4.4%). A greater proportion of patients with versus without post-PCI myocardial injury died during follow-up (7.9% versus 3.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). After adjustment for demographics and clinical covariates, post-PCI myocardial injury was associated with an excess hazard for long-term mortality (hazard ratio, 1.46 [95% CI, 1.20\u20131.78]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Myocardial injury defined by elevated CKMB early after PCI is common and associated with all-cause, long-term mortality. More complex coronary anatomy is predictive of post-PCI myocardial injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.124.014934","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T06:16:41Z","timestamp":1743401801000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Periprocedural Myocardial Injury Using CKMB Following Elective PCI: Incidence and Associations With Long-Term Mortality"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4765-4250","authenticated-orcid":true,"given":"Nina","family":"Talmor","sequence":"first","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Graves","sequence":"additional","affiliation":[{"name":"Department of Medicine, Columbia University Medical Center, New York, NY (C.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Kozloff","sequence":"additional","affiliation":[{"name":"Department of Medicine (S.K.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2604-3458","authenticated-orcid":true,"given":"Vincent J.","family":"Major","sequence":"additional","affiliation":[{"name":"Department of Population Health (V.J.M., Y.X.) New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5723-7648","authenticated-orcid":true,"given":"Yuhe","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Population Health (V.J.M., Y.X.) New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-8001","authenticated-orcid":true,"given":"Binita","family":"Shah","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."},{"name":"Veterans Affairs New York Harbor Healthcare System, NY (B.S., N.R.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anvar","family":"Babaev","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0306-6182","authenticated-orcid":true,"given":"Louai","family":"Razzouk","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2914-0894","authenticated-orcid":true,"given":"Sunil V.","family":"Rao","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Attubato","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Feit","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1478-3447","authenticated-orcid":true,"given":"James","family":"Slater","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-2815","authenticated-orcid":true,"given":"Nathaniel R.","family":"Smilowitz","sequence":"additional","affiliation":[{"name":"Leon H. 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