{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:47:01Z","timestamp":1781009221694,"version":"3.54.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND:<\/jats:title>\n            <jats:p>Coronary stenting alters vessel dynamics, displacing hinge movement closer to stent edges. We aimed to investigate whether calcified nodules (CNs) are more frequent at stent edges associated with calcium.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS:<\/jats:title>\n            <jats:p>In vessels with previously implanted stents evaluated by optical coherence tomography, 4 different calcified lesions were studied: stent-edge calcified lesions with or without a CN, and unstented native calcified lesions with or without a CN.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS:<\/jats:title>\n            <jats:p>\n              In 801 patients, 989 stent-edge calcified lesions and 354 unstented native calcified lesions were identified. Stent-edge calcified lesions exhibited a higher prevalence of CNs versus native calcified lesions (15.7% versus 5.1%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              &lt;0.001) and were observed in locations (mid left anterior descending artery, mid left circumflex, or branches) where no unstented native vessel CNs were seen. Stent-edge (versus native vessel) location (odds ratio [OR], 4.58 [95% CI, 2.23\u20139.43]) predicted the presence of a CN. Correspondingly, greater angiographic (systole-diastole) \u2206angle at the stent edge or unstented lesion (per 10\u00b0, OR, 2.27 [95% CI, 1.43\u20133.60]) and greater calcium burden: calcium length (per 10 mm, OR, 4.04 [95% CI, 2.36\u20136.92]), maximum calcium arc (per 90\u00b0, OR, 1.65 [95% CI, 1.25\u20132.17]), and maximum calcium thickness (per 0.1 mm, OR, 1.25 [95% CI, 1.15\u20131.36]) were associated with the presence of a CN. Stent-edge CNs were associated with a higher rate of stent-edge calcified lesion-related major adverse cardiac events (a composite of cardiac death, target vessel-related myocardial infarction, clinically driven target lesion revascularization, or definite\/probable stent thrombosis) compared with stent edges without a CN (15.9% versus 6.5%;\n              <jats:italic toggle=\"yes\">P<\/jats:italic>\n              =0.01), mainly driven by target lesion revascularization.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS:<\/jats:title>\n            <jats:p>Stent-edge calcium may predispose to the development of a CN. Stent-edge CNs were associated with a higher major adverse cardiac events rate than stent edges without a CN, whether treated or untreated.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/circinterventions.124.015028","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T05:00:20Z","timestamp":1747026020000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Stent-Edge Hinge Movement in a Calcified Lesion Is Associated With Increased Prevalence of a Calcified Nodule at Follow-Up"],"prefix":"10.1161","volume":"18","author":[{"given":"Yoichiro","family":"Sugizaki","sequence":"first","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0247","authenticated-orcid":true,"given":"Mitsuaki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takunori","family":"Tsukui","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Kido","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-5732","authenticated-orcid":true,"given":"Doosup","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-6497","authenticated-orcid":true,"given":"Koshiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-9970","authenticated-orcid":true,"given":"Ali","family":"Dakroub","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Granville","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genie M.","family":"Miraglia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylee","family":"Bressler","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin C.","family":"Magee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-7919","authenticated-orcid":true,"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-8665","authenticated-orcid":true,"given":"Omar K.","family":"Khalique","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":true,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-8705","authenticated-orcid":true,"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9422-048X","authenticated-orcid":true,"given":"Richard A.","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-4686","authenticated-orcid":true,"given":"Allen","family":"Jeremias","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-3197","authenticated-orcid":true,"given":"Ziad A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Department of Cardiology, St. Francis Hospital, Roslyn, NY (Y.S., E.S., D.S., K.S., A.D., M.J.G., G.M.M., K.B., C.T., J.C.M., J.W.M., O.K.K., D.J.C., R.A.S., A.J., Z.A.A.)."},{"name":"New York Institute of Technology, Old Westbury (Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8447","authenticated-orcid":true,"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Clinical Trials Center, Cardiovascular Research Foundation, New York, NY (Y.S., M.M., Y.-W.C., T.T., T.K., J.W.M., O.K.K., D.J.C., G.S.M., A.J., Z.A.A., A.M.)."},{"name":"Division of Cardiology, Columbia University Medical Center\/NewYork-Presbyterian Hospital (Y.S., Y.-W.C., T.T., T.K., J.W.M., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.03.009"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.071"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2017.05.013"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-01120"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030412"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.09.002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.016"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004231"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-24-00362"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1114\/1.1458594"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9149(97)00016-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00570-2"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-20-1233"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.055004"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.02.025"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20942"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.05.075"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0021-9290(00)00066-x"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.124.014215"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2020.07.005"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_3_3_23_2","volume-title":"Textbook of Interventional Cardiology","author":"Andalib A","year":"2016","unstructured":"Andalib A, Almonacid A, Popma J. Qualitative and quantitative coronary angiography. In: Topol E, ed. Textbook of Interventional Cardiology, 7th edition. Elsevier Health Sciences; 2016.","edition":"7"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.7.1959"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029289"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2305861"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000617"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.124.015028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T18:00:21Z","timestamp":1752602421000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.124.015028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.124.015028"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.124.015028","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}