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Much of the societal guidance regarding revascularization with coronary artery bypass grafting in ischemic cardiomyopathy comes from the STICH trial (Surgical Treatment for Ischemic Heart Failure) which predates improvements in medical therapy. More recently, the REVIVED-BCIS2 trial (Revascularization for Ischemic Ventricular Dysfunction-British Cardiovascular Intervention Society) failed to show a benefit of percutaneous coronary intervention on heart failure hospitalization and mortality in ischemic cardiomyopathy over contemporary medical therapy alone. Yet, there are outstanding questions regarding the role and modality of revascularization required to improve outcomes. We review current data and future directions in the management of ischemic cardiomyopathy and the potential role of revascularization.<\/jats:p>","DOI":"10.1161\/circinterventions.125.014625","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T09:00:15Z","timestamp":1757926815000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Current Concepts in Revascularization for Ischemic Heart Disease With Reduced Ejection Fraction"],"prefix":"10.1161","volume":"18","author":[{"given":"Ramya C.","family":"Mosarla","sequence":"first","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine, New York, NY (R.C.M., J.S.H., L.A., S.D.K., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-5981","authenticated-orcid":true,"given":"Judith S.","family":"Hochman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine, New York, NY (R.C.M., J.S.H., L.A., S.D.K., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-4690","authenticated-orcid":true,"given":"Leon","family":"Axel","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine, New York, NY (R.C.M., J.S.H., L.A., S.D.K., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravichandran","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY (R.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2340-2021","authenticated-orcid":true,"given":"Stuart D.","family":"Katz","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine, New York, NY (R.C.M., J.S.H., L.A., S.D.K., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-0652","authenticated-orcid":true,"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Division of Cardiology, NYU Grossman School of Medicine, New York, NY (R.C.M., J.S.H., L.A., S.D.K., S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.623199"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(01)01738-7"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.049755"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001303"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2451061219"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001168"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)00431-O"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.069"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.073"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200010193431602"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2018.00178"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00506-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01766-6"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065300"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10090362"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.066605"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000109691.16944.DA"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908263410901"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.021092"},{"key":"e_1_3_2_25_2","first-page":"V102","article-title":"Coronary artery surgery study (CASS): a randomized trial of coronary bypass surgery. 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