{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:30:50Z","timestamp":1788820250589,"version":"build-2803163510"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Drug-coated balloons (DCBs) are now a Food and Drug Administration-approved treatment option for the management of in-stent restenosis (ISR) based on superior outcomes compared with plain old balloon angioplasty (POBA) alone. However, the efficacy of DCB compared with drug-eluting stent (DES; repeat stenting) for ISR is uncertain, with prior studies showing inferiority of DCB. We aimed to compare the outcomes of DES, DCB, or POBA in patients with coronary ISR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, EMBASE, and\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      databases (until August 1, 2025) for randomized clinical trials that compared DCB, DES, or POBA alone for ISR. Outcomes included major adverse cardiovascular events, target lesion revascularization, all-cause mortality, cardiovascular mortality, stent thrombosis, late lumen loss, and postprocedure minimum lumen diameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>From 18 randomized clinical trials that randomized 3820 patients with ISR, at mean follow-up of 18 months, compared with POBA, both DCB and DES were associated with reduction in major adverse cardiovascular events (odds ratio, 0.34 [95% CI, 0.24\u20130.50]; odds ratio, 0.37 [95% CI, 0.25\u20130.54]) driven by reduction in target lesion revascularization (odds ratio, 0.28 [95% CI, 0.15\u20130.50]; odds ratio, 0.21 [95% CI, 0.10\u20130.42]). DCB had a lower postprocedure minimum lumen diameter but lower late lumen loss (mean difference, \u22120.16 [95% CI, \u22120.29 to \u22120.04] mm) compared with DES with no difference in other clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with ISR, DCB reduced major adverse cardiovascular events\/target lesion revascularization compared with POBA. There was no significant difference in clinical outcomes between DCB and DES.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/PROSPERO\">https:\/\/www.crd.york.ac.uk\/PROSPERO<\/jats:ext-link>\n                      ; Unique identifier: CRD42024598433.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015161","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T10:00:53Z","timestamp":1762941653000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Drug-Eluting Stent, Drug-Coated Balloon, or Plain Old Balloon Angioplasty for In-Stent Coronary Restenosis: Insights From a Mixed Treatment Comparison Meta-Analysis of Randomized Trials"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-4448","authenticated-orcid":true,"given":"M. Haisum","family":"Maqsood","sequence":"first","affiliation":[{"name":"Department of Cardiology (M.H.M.), DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7946-6094","authenticated-orcid":true,"given":"Robert S.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine (R.S.Z.), New York Presbyterian Hospital, Weill Cornell Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nil","family":"Rawal","sequence":"additional","affiliation":[{"name":"Department of Medicine (N.R.), New York Presbyterian Hospital, Weill Cornell Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-6471","authenticated-orcid":true,"given":"Gal","family":"Sella","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, Department of Cardiology (G.S., N.S.K.), DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-8133","authenticated-orcid":true,"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology, Department of Cardiology (G.S., N.S.K.), DeBakey Heart and Vascular Center, Houston Methodist Hospital, TX."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-0652","authenticated-orcid":true,"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, New York University Grossman School of Medicine 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