{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T14:11:46Z","timestamp":1792159906831,"version":"4.4.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Calcified nodules (CNs) remain a major challenge in percutaneous coronary intervention (PCI). We sought to compare procedural and clinical outcomes after orbital atherectomy (OA) versus intravascular lithotripsy (IVL)-facilitated PCI in patients with CNs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We identified patients with optical coherence tomography (OCT)-defined CNs who underwent PCI with either OA or IVL between 2012 and 2022 and had both pre- and post-PCI OCT images available. The imaging end point was the minimal stent area on final post-PCI OCT. The clinical end point was 2-year target-lesion failure, a composite of cardiac death, target-vessel myocardial infarction, or clinically driven target-lesion revascularization. A multivariable Cox proportional hazards regression model was used to estimate hazard ratio and 95% CI. Sensitivity analyses were performed using propensity score matching, incorporating covariates such as age, sex, diabetes, and pre-PCI calcium burden assessed by OCT (length, arc, and thickness).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 4856 patients with evaluable pre- and post-PCI OCT images, 493 patients (10.2%) had CNs, and 167 patients underwent PCI with either OA (n=83) or IVL (n=84). The 2 groups had similar baseline demographic and lesion characteristics. After PCI, final minimal stent area was comparable between the 2 groups (OA, 5.6 mm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 4.8\u20136.7] versus IVL, 5.5 mm\n                      <jats:sup>2<\/jats:sup>\n                      [interquartile range, 4.8\u20137.0];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.75). At a median follow-up of 2.4 years, there was no difference in target-lesion failure between the OA and IVL groups (12.0% versus 9.8%, respectively; log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.64; adjusted hazard ratio, 1.10 [95% CI, 0.28\u20134.31];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.89). Overall results remained consistent in the propensity score-matched population (n=68 per group), with similar minimal stent area (5.6 mm\n                      <jats:sup>2<\/jats:sup>\n                      [4.8\u20136.7] versus 5.5 mm\n                      <jats:sup>2<\/jats:sup>\n                      [4.7\u20136.8];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.73) and comparable 2-year target-lesion failure rate (9.8% versus 8.8%; log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.82).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with OCT-defined CNs, OA- and IVL-assisted PCI resulted in comparable post-PCI minimal stent area and 2-year clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015254","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T09:00:15Z","timestamp":1755248415000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Procedural and Clinical Outcomes After Orbital Atherectomy Versus Intravascular Lithotripsy in Patients With Calcified Nodules"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6117-9970","authenticated-orcid":true,"given":"Ali H.","family":"Dakroub","sequence":"first","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-5732","authenticated-orcid":true,"given":"Doosup","family":"Shin","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0343-9740","authenticated-orcid":true,"given":"Mandeep","family":"Singh","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"New York Institute of Technology, Old Westbury, NY (M.S., Y.C., O.K.K., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5311-1164","authenticated-orcid":true,"given":"Sarah","family":"Malik","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7471-1006","authenticated-orcid":true,"given":"Rick H.J.A.","family":"Volleberg","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"Radboud University Medical Center, Nijmegen, the Netherlands (R.H.J.A.V., T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6847-8057","authenticated-orcid":true,"given":"Jonathan","family":"Weber","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4646-4113","authenticated-orcid":true,"given":"Yasemin","family":"Ciftcikal","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"New York Institute of Technology, Old Westbury, NY (M.S., Y.C., O.K.K., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysse","family":"Fazal","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-6497","authenticated-orcid":true,"given":"Koshiro","family":"Sakai","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9606-3246","authenticated-orcid":true,"given":"Takao","family":"Sato","sequence":"additional","affiliation":[{"name":"Radboud University Medical Center, Nijmegen, the Netherlands (R.H.J.A.V., T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-8447","authenticated-orcid":true,"given":"Akiko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M.M., J.W.M., G.S.M.)."},{"name":"Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York City, NY (A.M., J.W.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2082-0247","authenticated-orcid":true,"given":"Mitsuaki","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M.M., J.W.M., G.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8842-7919","authenticated-orcid":true,"given":"Jeffrey W.","family":"Moses","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M.M., J.W.M., G.S.M.)."},{"name":"Department of Medicine, Division of Cardiology, Columbia University Irving Medical Center, New York City, NY (A.M., J.W.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3296-8705","authenticated-orcid":true,"given":"Gary S.","family":"Mintz","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation, New York, NY (A.M., M.M., J.W.M., G.S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1850-8665","authenticated-orcid":true,"given":"Omar K.","family":"Khalique","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"New York Institute of Technology, Old Westbury, NY (M.S., Y.C., O.K.K., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Sosa","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0907-5258","authenticated-orcid":true,"given":"Evan","family":"Shlofmitz","sequence":"additional","affiliation":[{"name":"St Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., 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Francis Hospital and Heart Center, Roslyn, NY (A.H.D., D.S., M.S., S.M., R.H.J.A.V., J.W., Y.C., A.F., K.S., J.W.M., O.K.K., F.S., E.S., A.J., R.A.S., Z.A.A.)."},{"name":"New York Institute of Technology, Old Westbury, NY (M.S., Y.C., O.K.K., Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.016"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.02.015"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.09.079"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.91.7.1959"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.03.009"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.012898"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0241836"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.63667"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6456695"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28896"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.03.032"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-24-00282"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.125.015254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:08:25Z","timestamp":1781791705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.125.015254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.125.015254"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.125.015254","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}