{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T04:37:24Z","timestamp":1780720644476,"version":"3.54.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>There were no previous studies comparing aspirin with clopidogrel on top of oral anticoagulation (OAC) within 1 year after percutaneous coronary intervention when dual therapy with OAC and clopidogrel was recommended.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We conducted a subgroup analysis stratified by OAC in the 1-year follow-up of the STOPDAPT-3 trial (Short and Optimal Duration of Dual Antiplatelet Therapy-3), which randomly compared 1-month dual antiplatelet therapy followed by aspirin monotherapy (aspirin group) with 1-month prasugrel monotherapy followed by clopidogrel monotherapy (clopidogrel group). This subgroup analysis compared aspirin with clopidogrel in patients with or without OAC by the 30-day landmark analysis. The coprimary end points were the cardiovascular (a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, or ischemic stroke), and bleeding end points (Bleeding Academic Research Consortium 3 or 5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In the 30-day landmark analysis (N=5809), there were 788 patients (13.6%) with OAC at discharge. Regardless of OAC, the incidence rates beyond 30 days up to 1 year were similar between the aspirin and clopidogrel groups for cardiovascular end point (OAC: 3.7% versus 3.9%, hazard ratio, 0.92 [95% CI, 0.44\u20131.93]; no OAC: 3.7% versus 3.6%; hazard ratio, 1.03 [95% CI, 0.77\u20131.38];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      interaction=0.78) and for bleeding end point (OAC: 3.5% versus 4.2%, hazard ratio, 0.82 [95% CI, 0.39\u20131.73]; no OAC 1.5% versus 1.4%, hazard ratio, 1.07 [95% CI, 0.66\u20131.72];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      interaction=0.57).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Aspirin compared with clopidogrel was associated with similar cardiovascular and bleeding outcomes beyond 30 days and up to 1 year after percutaneous coronary intervention regardless of OAC at discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04609111.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015495","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:00:15Z","timestamp":1758704415000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Aspirin Versus Clopidogrel Beyond 1 Month After PCI in Patients With Oral Anticoagulation"],"prefix":"10.1161","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct04609111","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Masahiro","family":"Natsuaki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Saga University, Japan (M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9443-5915","authenticated-orcid":true,"given":"Hirotoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital, Japan (H.W., H.T., Takeshi Kimura)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6844-739X","authenticated-orcid":true,"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan (T.M., Tomoya Kimura)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9291-9617","authenticated-orcid":true,"given":"Ko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan (K.Y., K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0387-8877","authenticated-orcid":true,"given":"Yuki","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan (Y.O., R.N., K.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5038-1292","authenticated-orcid":true,"given":"Ryusuke","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan (Y.O., R.N., K.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5575-9035","authenticated-orcid":true,"given":"Tomoya","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan (T.M., Tomoya Kimura)."},{"name":"Department of Cardiology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan (Tomoya Kimura)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0699-4248","authenticated-orcid":true,"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyusyu, Japan (K.Y., K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7614-0937","authenticated-orcid":true,"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Juntendo University Shizuoka Hospital, Izunokuni, Japan (S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-0344","authenticated-orcid":true,"given":"Tsuyoshi","family":"Isawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kousei Hospital, Japan (T. Isawa)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital, Japan (H.W., H.T., Takeshi Kimura)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-5165","authenticated-orcid":true,"given":"Tetsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan (T. Ishikawa)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8655-0203","authenticated-orcid":true,"given":"Toshihiro","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tenri Hospital, Japan (T.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kandoh","family":"Kawahatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Teine Keijinkai Hospital, Japan (K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3062-3981","authenticated-orcid":true,"given":"Fujio","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Center, Japanese Red Cross Osaka Hospital (F.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-7646","authenticated-orcid":true,"given":"Masaharu","family":"Akao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kyoto Medical Center, Japan (M.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Serikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka Wajiro Hospital, Japan (T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-3485","authenticated-orcid":true,"given":"Hiroyoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Showa University Fujigaoka Hospital, Yokohama, Japan (H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kindai University Faculty of Medicine, Osakasayama, Japan (T. Kawamura)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-1968","authenticated-orcid":true,"given":"Arata","family":"Hagikura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Tsukazaki Hospital, Himeji, Japan (A.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6748-1505","authenticated-orcid":true,"given":"Naoki","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ogaki Municipal Hospital, Japan (N.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4163-980X","authenticated-orcid":true,"given":"Koh","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan (Y.O., R.N., K.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5665-4076","authenticated-orcid":true,"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital, Japan (H.W., H.T., Takeshi Kimura)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61751-7"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001168"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001309"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611594"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817083"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30315-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae617"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.066720"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68845-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392303"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl488"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00449-0"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.31.7.1779"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01063-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.013"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.17242"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.125.015495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T19:00:28Z","timestamp":1763492428000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.125.015495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.125.015495"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.125.015495","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}