{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:58:27Z","timestamp":1783382307588,"version":"3.54.6"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The current study aims to describe outcomes after transcatheter valve replacement in adults with congenital heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Retrospective study of adults with congenital heart disease who underwent transcatheter valve replacement and had a 1-year follow-up postintervention at Mayo Clinic (2010\u20132024). The study period was divided into early (2010\u20132014), mid (2015\u20132019), and late (2020\u20132024) eras. The primary outcome was valve reintervention. The secondary outcomes were all-cause mortality and temporal change in prosthetic valve gradient and clinical indices of disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Overall, 341 patients (age 38\u00b117 years; 175 [51%] men) received 346 prostheses (pulmonary [N=236, 68%], tricuspid [N=75, 22%], aortic [N=22, 8%], and mitral [N=7, 2%]). The prostheses were Sapien (N=181, 52%), Melody (N=142, 41%), and Harmony prostheses (N=23, 7%). The number of transcatheter valve implantations increased from the early era (N=75), mid era (N=109), to the late era (N=162). The 10-year incidence of valve reintervention was 35%, and was similar between Sapien versus Melody prosthesis (41% versus 33%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.11). The 10-year incidence of all-cause mortality was 13%. There was a temporal increase in prosthetic valve Doppler mean gradient (baseline versus 10 years) for pulmonary (12\u00b15 versus 28\u00b111 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), tricuspid (3\u00b11 versus 8\u00b13 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and aortic prosthesis (13\u00b15 versus 26\u00b112 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). There was a temporal increase in predicted peak oxygen consumption (absolute \u2206, 9% [95% CI, 4\u201313];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.006) and a decrease in NT-proBNP (N-terminal pro-B-type natriuretic peptide) level (absolute \u2206, \u2212138 pg\/mL [95% CI, \u2212209 to \u221264];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) at 1-year postintervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>There has been a temporal increase in the number of transcatheter valve implantations over time. Transcatheter valve replacement was associated with clinical improvement across multiple domains. However, there was a significant increase in prosthetic valve gradient within 10 years of follow-up, suggesting limited prosthesis longevity. There is a need for strategies to improve prosthetic valve longevity, which in turn may improve outcomes in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015667","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T09:00:19Z","timestamp":1761555619000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Transcatheter Valve Replacement in Adults With Congenital Heart Disease\u2014The Mayo Clinic Experience"],"prefix":"10.1161","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8810-3631","authenticated-orcid":true,"given":"Alexander C.","family":"Egbe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine (A.C.E., M.F.E., C.S.R.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-0003","authenticated-orcid":true,"given":"Allison K.","family":"Cabalka","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology (A.K.C., N.W.T., D.J.H., J.H.A.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-8207","authenticated-orcid":true,"given":"Nathaniel W.","family":"Taggart","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology (A.K.C., N.W.T., D.J.H., J.H.A.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0331-3294","authenticated-orcid":true,"given":"Donald J.","family":"Hagler","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology (A.K.C., N.W.T., D.J.H., J.H.A.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-5379","authenticated-orcid":true,"given":"Mackram F.","family":"Eleid","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (A.C.E., M.F.E., C.S.R.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2044-4664","authenticated-orcid":true,"given":"Charanjit S.","family":"Rihal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine (A.C.E., M.F.E., C.S.R.), Mayo Clinic Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-0707","authenticated-orcid":true,"given":"Jason H.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology (A.K.C., N.W.T., D.J.H., J.H.A.), Mayo Clinic Rochester, 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