{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:53:43Z","timestamp":1793825623190,"version":"4.6.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The best management of coronary artery disease in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) is debated. We investigated the clinical impact of the residual extent of myocardium at risk in patients undergoing TAVI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Patients enrolled in the REVASC-TAVI (Management of Myocardial Revascularization in Patients Undergoing TAVI With Coronary Artery Disease) international multicenter registry were stratified according to the myocardium jeopardized by coronary artery disease using the British Cardiovascular Intervention Society Jeopardy Score (BCIS-JS) after a planned coronary revascularization. A planned revascularization included percutaneous coronary interventions performed before TAVI, during TAVI, or within 1 month after TAVI. The study population was divided according to the residual BCIS-JS (rBCIS-JS): patients with extensive residual myocardial at risk (rBCIS-JS &gt;4 group) and patients without extensive residual myocardial at risk (rBCIS-JS \u22644 group). The primary study end point was the composite of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and rehospitalization for heart failure at 2 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among the 2407 patients enrolled, 294 pairs of patients were selected by propensity matching and compared. At 2-year follow-up, the incidence of the primary end point was higher in patients with rBCIS-JS &gt;4 compared with patients with rBCIS-JS \u22644 (37.5% versus 23.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.004). A significantly lower rate of myocardial infarction was reported in patients with BCIS-JS \u22644 (8.2% versus 2.6%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.011). At multivariate analysis, rBCIS-JS &gt;4 (hazard ratio, 1.43 [95% CI, 1.11\u20131.84];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.005) independently predicted 2-year major adverse cardiac and cerebrovascular events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with concomitant coronary artery disease and severe aortic stenosis, the residual myocardial risk significantly affects TAVI outcomes. In particular, a rBCIS-JS &gt;4 is associated with higher rates of major adverse cardiac and cerebrovascular events at 2 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015770","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:01:19Z","timestamp":1779267679000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Impact of Myocardium at Risk in Transcatheter Aortic Valve Implantation"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6391-422X","authenticated-orcid":true,"given":"Cristina","family":"Aurigemma","sequence":"first","affiliation":[{"name":"Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy (C.A., M.L., F. Burzotta)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":true,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.U. Policlinico G. Rodolico-San Marco, Catania, Italy (G.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-9045","authenticated-orcid":true,"given":"Giulia","family":"Laterra","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Enna Kore, Italy (G.L., M. Barbanti)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8721-4068","authenticated-orcid":true,"given":"Thomas","family":"Pilgrim","sequence":"additional","affiliation":[{"name":"Bern University Hospital, Inselspital, University of Bern, Switzerland (T. Pilgrim, D. Tomii)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2311-4129","authenticated-orcid":true,"given":"Ignacio J.","family":"Amat Santos","sequence":"additional","affiliation":[{"name":"Centro de investigaci\u00f3n Biom\u00e9dica en red-Enfermedades Cardiovasculares (CIBERCV). Hospital Cl\u00ednico Universitario de Valladolid, Spain (I.J.A.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0278","authenticated-orcid":true,"given":"Ole","family":"De Backer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Algemeen Ziekenhuis Turnhout, Belgium (O.D.B., P.N.)."},{"name":"Department of Clinical Medicine, Copenhagen University, Denmark (O.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0799-7478","authenticated-orcid":true,"given":"Won-Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Justus-Liebig University of Giessen, Cardiology &amp; Angiology, Germany (W.-K.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1273-1823","authenticated-orcid":true,"given":"Henrique","family":"Barbosa Ribeiro","sequence":"additional","affiliation":[{"name":"Heart Institute of Sao Paulo (InCor), University of Sao Paulo, Brazil (H.B.R., S.F.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-2649","authenticated-orcid":true,"given":"Francesco","family":"Saia","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiac Thoracic and Vascular Department, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Italy (F.S., T. Palmerini, M.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7269-8944","authenticated-orcid":true,"given":"Matjaz","family":"Bunc","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana, Slovenia (M. Bunc, K.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7243-9408","authenticated-orcid":true,"given":"Didier","family":"Tchetche","sequence":"additional","affiliation":[{"name":"Clinique Pasteur, Toulouse, France (D. Tchetche, V.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8960-7006","authenticated-orcid":true,"given":"Philippe","family":"Garot","sequence":"additional","affiliation":[{"name":"Institut Cardio-vasculaire Paris Sud (ICPS), H\u00f4pital Priv\u00e9 Jacques Cartier, Ramsay-Sant\u00e9, Massy, France (P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-0304","authenticated-orcid":true,"given":"Flavio Luciano","family":"Ribichini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Azienda Ospedaliera Universitaria Integrata di Verona, Italy (F.L.R., P.A.D.S., A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mylotte","sequence":"additional","affiliation":[{"name":"Galway University Hospital, Ireland (D.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5303","authenticated-orcid":true,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan (Y.W., H.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Division of Cardiology, IRCSS Policlinico San Donato, Italy (F. 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