{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:47:57Z","timestamp":1787870877629,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Right heart catheterization plays a pivotal role in the preprocedural evaluation of patients considered for transcatheter tricuspid valve edge-to-edge repair. This study aimed to explore the potential impact of hemodynamic parameters obtained through right heart catheterization on patient-centered outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This study represents a subanalysis from the multicenter EuroTR registry (European Registry of Transcatheter Repair for Tricuspid Regurgitation). Patients with invasive hemodynamic data who underwent isolated transcatheter tricuspid valve edge-to-edge repair for significant tricuspid regurgitation were included. Outcomes of interest were a composite of 2-year all-cause death or hospitalization for heart failure (HFH) and a patient-centered composite of 6-month all-cause mortality, HFH, New York Heart Association class IV\/worsening New York Heart Association class compared with baseline. Secondary outcome included postprocedural New York Heart Association class improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Seven hundred and eleven patients were included in the analysis. Two-year survival free from death and HFH was 63%. Optimal prognostic thresholds identified for death and HFH at 2 years were: mean pulmonary artery pressure\u226532 mm\u2009Hg, pulmonary capillary wedge pressure (PCWP)\u226520 mm\u2009Hg, and pulmonary vascular resistance\u22655 wood units (WU). The early patient-centered composite outcome occurred in 25% of cases. PCWP\u226520 mm\u2009Hg was independently associated with an early clinical deterioration (hazard ratio, 2.77 [95% CI, 1.47\u20135.28];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and with 2-year death\/HFH (hazard ratio, 1.75 [95% CI, 1.03\u20133.02];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04). No invasive parameter was associated with residual tricuspid regurgitation \u22653+. New York Heart Association class improved significantly throughout the follow-up (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), although patients with elevated mean pulmonary artery pressure (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04) or PCWP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01) experienced less symptomatic benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients undergoing transcatheter tricuspid valve edge-to-edge repair, invasive hemodynamics\u2014especially elevated PCWP\u2014are independently associated with early patient-centered outcomes and late adverse clinical events. Despite overall improvement of the functional status and no impact on residual tricuspid regurgitation, patients with higher mean pulmonary artery pressure or PCWP benefit less. These findings support the role of comprehensive right heart catheterization in preprocedural risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT06307262.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015964","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:00:18Z","timestamp":1763114418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Invasive Hemodynamics and Risk Stratification in T-TEER: Moving Beyond ESC Thresholds - EuroTR Registry Insights"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"nct06307262","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4209-6824","authenticated-orcid":true,"given":"Giulia","family":"Masiero","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padua, Italy (G.M., F.A., S.C., A. Panza, G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4679-6773","authenticated-orcid":true,"given":"Federico","family":"Arturi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padua, Italy (G.M., F.A., S.C., A. Panza, G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ceni","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padua, Italy (G.M., F.A., S.C., A. Panza, G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7854-0583","authenticated-orcid":true,"given":"Andrea","family":"Panza","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padua, Italy (G.M., F.A., S.C., A. Panza, G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-6751","authenticated-orcid":true,"given":"Karl-Patrik","family":"Kresoja","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Cardiology I, University Medical Center of the Johannes Gutenberg-University Mainz, Germany (K.-P.K., S.R., P. Lurz)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3871-164X","authenticated-orcid":true,"given":"Jennifer","family":"von Stein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, University of Cologne, Germany (J.S., C.I.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Fortmeier","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz- und Diabeteszentrum NRW, Universit\u00e4tsklinik der Ruhr-Universit\u00e4t Bochum, Med. Fakult\u00e4t OWL (Universit\u00e4t Bielefeld), Bad Oeynhausen, Germany (V.F., M. Kassar, V.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Koell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart and Vascular Centre Hamburg, Germany (B.K., D.K.)."},{"name":"German Center of Cardiovascular Research (DZHK), Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany (B.K., D.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rottbauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center Ulm, Germany (W.R., M. Kessler)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kassar","sequence":"additional","affiliation":[{"name":"Clinic for General and Interventional Cardiology\/Angiology, Herz- und Diabeteszentrum NRW, Universit\u00e4tsklinik der Ruhr-Universit\u00e4t Bochum, Med. Fakult\u00e4t OWL (Universit\u00e4t Bielefeld), Bad Oeynhausen, Germany (V.F., M. Kassar, V.R.)."},{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Switzerland (M. Kassar, F.P.)."},{"name":"Graduate School for Health Sciences, University of Bern, Switzerland (M. Kassar)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Goebel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Center, Zentralklinik Bad Berka, Germany (B.G., P. Lauten)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-0203","authenticated-orcid":true,"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Heart Valve Center, Cardio-Thoracic-Vascular Department, IRCCS San Raffaele Scientific Institute, Milan, Italy (P.D., F.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-6820","authenticated-orcid":true,"given":"Paul","family":"Achouh","sequence":"additional","affiliation":[{"name":"Cardiology Department, European Hospital Georges Pompidou, Universit\u00e9 Paris Cit\u00e9, France (P.A., N.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"University Hospital Essen, University of Duisburg-Essen, West German Heart and Vascular Center, Department of Cardiology and Vascular Medicine, Germany (T.R., A.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7489-2935","authenticated-orcid":true,"given":"Manuel","family":"Barreiro-Perez","sequence":"additional","affiliation":[{"name":"Hospital \u00c1lvaro Cunqueiro, Vigo, Spain (M.B.-P., R.E.-L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2243-9809","authenticated-orcid":true,"given":"Peter","family":"Boekstegers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Helios Klinikum Siegburg, Germany (P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2920-6574","authenticated-orcid":true,"given":"Andreas","family":"R\u00fcck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden (A.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0754-8015","authenticated-orcid":true,"given":"Monika","family":"Zdanyte","sequence":"additional","affiliation":[{"name":"Medical Clinic III, University Hospital T\u00fcbingen, Germany (M.Z., T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-1815","authenticated-orcid":true,"given":"Marianna","family":"Adamo","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padua, Italy (G.M., F.A., S.C., A. Panza, G.T.)."},{"name":"ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Italy (M.A., M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-1473","authenticated-orcid":true,"given":"Flavien","family":"Vincent","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centre Hospitalier Universitaire De Lille, France (F. 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Voss, A. Polzin)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5891-9672","authenticated-orcid":true,"given":"Amin","family":"Polzin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Pulmonology and Angiology, Medical Faculty, Heinrich Heine University of D\u00fcsseldorf, Germany (F. Voss, A. 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