{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:57:45Z","timestamp":1790668665288,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Evidence regarding prosthesis\u2013patient mismatch (PPM), measured (mPPM), and predicted (pPPM), after transcatheter aortic valve replacement in bicuspid aortic valve stenosis remains limited. This study sought to evaluate the incidence, predictors, and prognostic implications of mPPM and pPPM in patients with Sievers type 1 bicuspid aortic valve undergoing transcatheter aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The AD-HOC registry is a retrospective, multicenter study including 781 patients with severe aortic stenosis and bicuspid aortic valve treated with transcatheter aortic valve replacement between 2016 and 2023 across 24 centers. PPM was defined according to Valve Academic Research Consortium-3 criteria. The primary outcome was all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Moderate-to-severe mPPM was more frequent than pPPM (22% versus 8%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Balloon-expandable valves were independently associated with both mPPM and pPPM, while smaller valve size and supra-annular sizing predicted only pPPM. During a mean follow-up of 621\u00b1470 days, neither mPPM nor pPPM was associated with mortality in the overall cohort. Among patients with a small annulus (\u2264430 mm\n                      <jats:sup>2<\/jats:sup>\n                      ; n=145), pPPM occurrence was significantly higher (19% versus 5.5%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and was associated with increased all-cause mortality, but not with cardiovascular mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In patients with Sievers type 1 bicuspid aortic valve undergoing transcatheter aortic valve replacement, pPPM occurred less frequently than mPPM and was predominantly driven by anatomic characteristics and sizing strategies. Although pPPM was associated with increased all-cause mortality among patients with small annuli, this association did not extend to cardiovascular mortality and should be considered hypothesis-generating. Further prospective investigations are warranted to better delineate the impact of anatomic constraints on clinical outcomes in this anatomically challenging subset.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.015994","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:00:32Z","timestamp":1778576432000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Measured Versus Predicted Prosthesis\u2013Patient Mismatch after TAVR in Sievers Type 1 BAV: Incidence, Determinants, and Outcomes From the AD-HOC Registry"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0818-3094","authenticated-orcid":true,"given":"Tommaso","family":"Fabris","sequence":"first","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua Medical School, Italy (T.F., F.A., M.N., C.F., L.N.F., G.M., F.C., F.P., A.P., G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4679-6773","authenticated-orcid":true,"given":"Federico","family":"Arturi","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua Medical School, Italy (T.F., F.A., M.N., C.F., L.N.F., G.M., F.C., F.P., A.P., G.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-7416","authenticated-orcid":true,"given":"Andrea","family":"Buono","sequence":"additional","affiliation":[{"name":"Valve Center, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy (A.B., M. Bellamoli, L. Bettari, A. Messina, M.L.D.R., D. Maffeo)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-3246","authenticated-orcid":true,"given":"Chiara","family":"de Biase","sequence":"additional","affiliation":[{"name":"Clinique Pasteur, Toulouse, France (C. de Biase, M. Boiago, D.T.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2272-1282","authenticated-orcid":true,"given":"Michele","family":"Bellamoli","sequence":"additional","affiliation":[{"name":"Valve Center, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy (A.B., M. Bellamoli, L. Bettari, A. Messina, M.L.D.R., D. Maffeo)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-6749","authenticated-orcid":true,"given":"Andrea","family":"Zito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy (A.Z., C.T., F.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3239-4046","authenticated-orcid":true,"given":"Antonio","family":"Mangieri","sequence":"additional","affiliation":[{"name":"Cardio Center, IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy (A. Mangieri, A. Latini)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-4063","authenticated-orcid":true,"given":"Nicholas","family":"Montarello","sequence":"additional","affiliation":[{"name":"The Heart Center, Rigshospitalet, Copenhagen University Hospital, Denmark (N.M., O.D.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":true,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"U.O.C. Cardiologia, Centro Alte Specialita\u0300 e Trapianti, P.O. G. Rodolico, A.O.U. Policlinico\u2013V. Emanuele, Universita\u0300 di Catania, Italy (Giuliano Costa)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-279X","authenticated-orcid":true,"given":"Mesfer","family":"Alfadhel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leeds Teaching Hospitals NHS Trust, United Kingdom (M. Alfadhel, D.J.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-8276","authenticated-orcid":true,"given":"Ofi","family":"Koren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (O.K., R.R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Fezzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospitals Galway, Ireland (S.F., D. 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