{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:46Z","timestamp":1792521586546,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Coronary stenting of bifurcation lesions has been associated with an increased risk of thrombotic events. However, the optimal duration of dual antiplatelet therapy (DAPT) after treatment of bifurcations, particularly among patients with high bleeding risk, is unknown. We aimed to evaluate the safety and efficacy of abbreviated DAPT in patients with high bleeding risk undergoing percutaneous coronary intervention (PCI) of bifurcation lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The MASTER DAPT trial (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Standard DAPT Regimen) randomized patients with high bleeding risk who were free from ischemic or bleeding events after 1 month of PCI to discontinue DAPT (abbreviated regimen) or continue DAPT for a minimum of 2 additional months (standard regimen). Coprimary outcomes were net adverse clinical outcomes events, major adverse cardiac and cerebral events, and BARC (Bleeding Academic Research Consortium) type 2, 3, or 5 bleeding at 335 days after randomization. This prespecified substudy evaluates the outcomes of abbreviated versus standard DAPT according to treatment of bifurcation lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 4579 patients randomized, 976 (21.2%) underwent bifurcation PCI. Net adverse clinical event and major adverse cardiac and cerebral events did not differ between abbreviated and standard DAPT in both patients with (hazard ratio [HR], 0.98 [95% CI, 0.73\u20131.17] and HR, 0.92 [95% CI, 0.63\u20131.54], respectively) and without bifurcation PCI (HR, 1.14 [95% CI, 0.67\u20131.93] and HR, 0.96 [95% CI, 0.74\u20131.25];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      interaction=0.803 and 0.563, respectively). Abbreviated DAPT consistently reduced BARC 2, 3, or 5 bleeding in patients with (HR, 0.83 [95% CI, 0.53\u20131.30]) or without (HR, 0.65 [95% CI, 0.51\u20130.82]) bifurcation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      interaction=0.321).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Among patients with high bleeding risk with or without bifurcation PCI, abbreviated DAPT was associated with lower bleeding risk without an excess of ischemic or net adverse events compared with standard DAPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03023020.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.016222","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T09:00:17Z","timestamp":1783933217000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Abbreviated Dual Antiplatelet Therapy in Patients With High Bleeding Risk Undergoing PCI of Bifurcation Lesions: A Prespecified Substudy of the MASTER DAPT Trial"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"nct03023020","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Bernard","family":"Chevalier","sequence":"first","affiliation":[{"name":"Institut Cardiovasculaire Paris-Sud, H\u00f4pital Priv\u00e9 Jacques Cartier, Ramsay-Sant\u00e9, Massy, France (B.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7755-4069","authenticated-orcid":true,"given":"Davide","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy (D.C.)."},{"name":"Department of Cardiology, Humanitas Gavazzeni, Bergamo, Italy (D.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9164-720X","authenticated-orcid":true,"given":"Pieter C.","family":"Smits","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maasstad Hospital, Rotterdam, the Netherlands (P.C.S., V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Brunel","sequence":"additional","affiliation":[{"name":"Cardiology Department, H\u00f4pital Priv\u00e9 Dijon-Bourgogne, Dijon, France (P.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Frigoli","sequence":"additional","affiliation":[{"name":"Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland (E.F., A.L., M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8766-7945","authenticated-orcid":true,"given":"Dik","family":"Heg","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Bern, Switzerland (D.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-3407","authenticated-orcid":true,"given":"Yoshiharu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Osaka Keisatsu Hospital, Japan (Y.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floris","family":"Kauer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Albert Schweitzer Hospital, Dordrecht, the Netherlands (F.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Landi","sequence":"additional","affiliation":[{"name":"Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland (E.F., A.L., M.V.)."},{"name":"Faculty of Biomedical Sciences, University of Italian Switzerland, Lugano, Switzerland (A.L., M.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2999-4961","authenticated-orcid":true,"given":"Renato D.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC (R.D.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Mainar","sequence":"additional","affiliation":[{"name":"Hospital General Alicante, Spain (V.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":true,"given":"Mamas","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele Cardiovascular Research Group, School of Medicine, Keele University, United Kingdom (M.A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hristo","family":"Mateev","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, National Heart Hospital, Sofia, Bulgaria (H.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Cardiology, East Lancashire Hospitals National Health Service Trust, Royal Blackburn Hospital, Blackburn, Lancashire, United Kingdom (J.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4851-9503","authenticated-orcid":true,"given":"E\u00f9gene P.","family":"McFadden","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Cork University Hospital, Ireland (E.P.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2968-0057","authenticated-orcid":true,"given":"Ajit","family":"Mulassari","sequence":"additional","affiliation":[{"name":"The Madras Medical Mission Hospital, Chennai, India (A.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahzad","family":"Munir","sequence":"additional","affiliation":[{"name":"Royal Wolverhampton National Health Service Trust, Wolverhampton, United Kingdom (S.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawed","family":"Polad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Jeroen Bosch Hospital, Den Bosch, the Netherlands (J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9890-5582","authenticated-orcid":true,"given":"Bernhard","family":"Reimers","sequence":"additional","affiliation":[{"name":"Cardio Center, Humanitas Research Hospital Istituto di Ricovero e Cura a Carattere Scientifico, Rozzano-Milan, Italy (B.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Sardella","sequence":"additional","affiliation":[{"name":"Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Italy (G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2011-0069","authenticated-orcid":true,"given":"Imre","family":"Ungi","sequence":"additional","affiliation":[{"name":"Division of Invasive Cardiology, Department of Internal Medicine, Center of Cardiology, University of Szeged, Hungary 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