{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:29:15Z","timestamp":1787077755173,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients with Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) was superior to clinical surveillance (CS) in asymptomatic severe aortic stenosis. The relative impact of early TAVR versus CS strategy by age is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The study population of the EARLY TAVR trial was stratified into 4 age groups: 65 to 69 years (n=141), 70 to 74 years (n=263), 75 to 79 years (n=250), and \u226580 years (n=247). Associations between age and the trial primary end point of death, stroke, or unplanned cardiovascular hospitalization; the composite end point of death, stroke, or heart failure hospitalization; and its individual components were examined. Interaction tests evaluated whether the treatment effect of early TAVR versus CS differed by age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      No interaction was detected between age and the treatment effect of early TAVR versus CS for the composites or individual outcomes. We observed lower stroke rates with early TAVR compared with CS in the youngest (65\u201369 years, absolute risk reduction, 13%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.008) and oldest (\u226580 years; absolute risk reduction, 12.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.029) age groups. The absolute difference in heart failure hospitalization rates between the early TAVR and CS arms at 2 years was greatest in the oldest patients (\u226580 years, 9.1%; 75\u201379 years, 5.9%; 70\u201374 years, 5.1%; 65\u201369 years, 4.4%). In the CS group, time to conversion to AVR was similar across all age groups (median, 11 months;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.73). Approximately one-third of younger patients (65\u201369 years) in the CS arm presented with acute valve syndrome at the time of conversion, the frequency of which tended to increase with age (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In the EARLY TAVR trial, the relative benefit of early TAVR over CS was consistent among all age groups. The greatest absolute reduction in stroke rate with early TAVR compared with CS appeared in the youngest and oldest groups, whereas reduction in heart failure hospitalization was most pronounced in the oldest patients. These data suggest that early TAVR should be considered in all age groups above 65 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>REGISTRATION:<\/jats:title>\n                    <jats:p>\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03042104.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.016370","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:00:13Z","timestamp":1780477213000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial"],"prefix":"10.1161","volume":"19","clinical-trial-number":[{"clinical-trial-number":"nct03042104","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3457-6887","authenticated-orcid":true,"given":"Kashish","family":"Goel","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine (K.G., B.R.L.), Vanderbilt University Medical Center, Nashville, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6879-5343","authenticated-orcid":true,"given":"Brian R.","family":"Lindman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine (K.G., B.R.L.), Vanderbilt University Medical Center, Nashville, TN."},{"name":"Structural Heart and Valve Center (B.R.L.), Vanderbilt University Medical Center, Nashville, TN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5576-2385","authenticated-orcid":true,"given":"Allan","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center\/NewYork-Presbyterian Hospital (A.S., D.J.C., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":true,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center\/NewYork-Presbyterian Hospital (A.S., D.J.C., M.B.L.)."},{"name":"Cardiovascular Research Foundation, New York, NY (D.J.C., M.B.L.)."},{"name":"St. Francis Hospital and Heart Center, Roslyn, NY (D.J.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gennaro","family":"Giustino","sequence":"additional","affiliation":[{"name":"Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (G.G., P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4817-024X","authenticated-orcid":true,"given":"J. Bradley","family":"Oldemeyer","sequence":"additional","affiliation":[{"name":"University of Colorado Health, Loveland (J.B.O., J. Strote)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Strote","sequence":"additional","affiliation":[{"name":"University of Colorado Health, Loveland (J.B.O., J. Strote)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-0846","authenticated-orcid":true,"given":"Vasilis","family":"Babaliaros","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, GA (V.B., C.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-9411","authenticated-orcid":true,"given":"Chandan M.","family":"Devireddy","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, GA (V.B., C.M.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0638-2025","authenticated-orcid":true,"given":"Michael P.","family":"Fischbein","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA (M.P.F., W.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-1368","authenticated-orcid":true,"given":"William F.","family":"Fearon","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Stanford University School of Medicine, CA (M.P.F., W.F.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Daniels","sequence":"additional","affiliation":[{"name":"Division of Cardiology, California Pacific Medical Center, San Francisco (D.D., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Spies","sequence":"additional","affiliation":[{"name":"Division of Cardiology, California Pacific Medical Center, San Francisco (D.D., C.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5309-3058","authenticated-orcid":true,"given":"Adnan K.","family":"Chhatriwalla","sequence":"additional","affiliation":[{"name":"Saint Luke\u2019s Mid America Heart Institute, Kansas City, MO (A.K.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6012-9648","authenticated-orcid":true,"given":"Hussam S.","family":"Suradi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center, Chicago, IL (H.S.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7557","authenticated-orcid":true,"given":"Pinak","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women\u2019s Hospital, Boston, MA (P. Shah)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-1825","authenticated-orcid":true,"given":"Molly","family":"Szerlip","sequence":"additional","affiliation":[{"name":"Baylor Scott and White The Heart Hospital Plano, TX (M.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2882-2597","authenticated-orcid":true,"given":"Thom","family":"Dahle","sequence":"additional","affiliation":[{"name":"CentraCare Heart &amp; Vascular Center, St. Cloud, MN (T.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4387-9038","authenticated-orcid":true,"given":"Dimitrios","family":"Apostolou","sequence":"additional","affiliation":[{"name":"Center for Structural Heart Disease, Henry Ford Health System, Detroit, MI (D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7763-2602","authenticated-orcid":true,"given":"Raj","family":"Makkar","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA (R.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0783-9995","authenticated-orcid":true,"given":"Charles J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine, Chicago, IL (C.J.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tej","family":"Sheth","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, McMaster University and Hamilton Health Sciences, Ontario, Canada (T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-854X","authenticated-orcid":true,"given":"Paul","family":"Sorajja","sequence":"additional","affiliation":[{"name":"Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, MN (P. Sorajja)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3920-5831","authenticated-orcid":true,"given":"James T.","family":"DeVries","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Section of Cardiovascular Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH (J.T.D.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-8888","authenticated-orcid":true,"given":"Jeffrey","family":"Southard","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, UC Davis Health System, University of California-Davis, Sacramento (J. Southard)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5095-2649","authenticated-orcid":true,"given":"Jeremiah P.","family":"Depta","sequence":"additional","affiliation":[{"name":"Sands-Constellation Heart Institute, Rochester Regional Health, NY (J.P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Cardiology, AMITA Alexian Brothers Medical Center, Elk Grove Village, IL (A.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Atrium Health Sanger Heart &amp; Vascular Institute, Charlotte, NC (M.J. Rinaldi)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-3002","authenticated-orcid":true,"given":"Salem","family":"Badr","sequence":"additional","affiliation":[{"name":"Prairie Education and Research Cooperative, Springfield, IL (S.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew R.","family":"Williams","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center (M.R.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Russo","sequence":"additional","affiliation":[{"name":"Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ (M.J. Russo)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9151-8096","authenticated-orcid":true,"given":"Mayra","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (M.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0452-2327","authenticated-orcid":true,"given":"James M.","family":"McCabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA (J.M.M.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":true,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Qu\u00e9bec Heart and Lung Institute, Laval University, Canada (P.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1870-0019","authenticated-orcid":true,"given":"Yizhuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Edwards Lifesciences, Irvine, CA (Y.W.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-7492","authenticated-orcid":true,"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center\/NewYork-Presbyterian Hospital (A.S., D.J.C., M.B.L.)."},{"name":"Cardiovascular Research Foundation, New York, NY (D.J.C., M.B.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5507-3712","authenticated-orcid":true,"given":"Philippe","family":"G\u00e9n\u00e9reux","sequence":"additional","affiliation":[{"name":"Gagnon Cardiovascular Institute, Morristown Medical Center, NJ (G.G., P.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2405880"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912846"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae585"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.22730"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.11.006"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2023.11.019"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.shj.2024.100377"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.125.074251"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.043486"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2024.100959"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx381"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.05.006"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.124.014945"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.028389"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.125.016370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:00:30Z","timestamp":1787076030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.125.016370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.125.016370"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.125.016370","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}