{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:54:57Z","timestamp":1789613697520,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Coronary vasomotor dysfunction is diagnosed by a coronary function testing (CFT). However, protocols vary, and the influence of access site and concomitant vasodilator medication on the diagnostic yield and safety of CFT is unclear. This study assessed the diagnostic yield and safety of CFT by radial access with intraarterial calcium channel blockers compared with CFT by femoral access.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Data were obtained from the Netherlands Registry of Invasive Coronary Vasomotor Function Testing, a Dutch multicenter collaboration on CFT. Patients who underwent CFT between December 2020 and July 2025 were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 1885 patients were included, 1436 (76.2%) with primary radial access and 380 (20.2%) with primary femoral access. In 69 (3.7%) patients conversion from radial to femoral access was necessary. The conversion group was analyzed separately. The total diagnostic yield of coronary vasomotor dysfunction was 78.5%. There was no significant difference in the prevalence of coronary vasomotor dysfunction between patients with primary radial versus femoral access (79.2% versus 75.3%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.1). There was also no difference in total diagnostic yield between the group without conversion and the conversion group (78.4% versus 82.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.4); however, spasm was more prevalent in the conversion group (67.7% versus 79.4%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04). There were no differences in CFT complication rates between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Primary radial access with routine administration of calcium channel blockers was not associated with a lower diagnostic yield in CFT than primary femoral access. Procedural safety was comparable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.016450","type":"journal-article","created":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T16:00:14Z","timestamp":1774800014000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnostic Yield and Safety of Invasive Coronary Function Testing After Radial Versus Femoral Access"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6130-8353","authenticated-orcid":true,"given":"Fleur W.","family":"Adriaansen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9253-5154","authenticated-orcid":true,"given":"Ca\u00efa","family":"Crooijmans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9615-9491","authenticated-orcid":true,"given":"Tijn P.J.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6785-3348","authenticated-orcid":true,"given":"Behruz","family":"Yosofi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., S.E.E.-S., A.C.D.-L., P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3261-9361","authenticated-orcid":true,"given":"Joan G.","family":"Meeder","sequence":"additional","affiliation":[{"name":"Department of Cardiology, VieCuri Medical Center, Venlo, The Netherlands (J.G.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-7105","authenticated-orcid":true,"given":"Yolande","family":"Appelman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, The Netherlands (Y.A., M.A.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7984-3021","authenticated-orcid":true,"given":"Marcel A.M.","family":"Beijk","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amsterdam University Medical Center, The Netherlands (Y.A., M.A.M.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0682-0619","authenticated-orcid":true,"given":"Tim P.","family":"van de Hoef","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (T.P.v.d.H., T.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2952-4849","authenticated-orcid":true,"given":"Timo","family":"Nijkamp","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands (T.P.v.d.H., T.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9762-014X","authenticated-orcid":true,"given":"Hester M.","family":"den Ruijter","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, University Medical Center Utrecht, The Netherlands (H.M.d.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-6774","authenticated-orcid":true,"given":"Annemiek M.J.","family":"de Vos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Catharina Hospital, Eindhoven, The Netherlands (A.M.J.d.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-7819","authenticated-orcid":true,"given":"Valeria","family":"Paradies","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maasstad Hospital, Rotterdam, The Netherlands (V.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5421-5205","authenticated-orcid":true,"given":"Martijn","family":"Meuwissen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Amphia Hospital, Breda, The Netherlands (M.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola S.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands (N.S.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els G.M.","family":"Olde Bijvank","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Haaglanden Medical Center, Den Haag, The Netherlands (E.G.M.O.B.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibtihal","family":"Al Amri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, The Netherlands (I.A.A., M.C.d.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4835-5268","authenticated-orcid":true,"given":"Melina C.","family":"den Haan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, The Netherlands (I.A.A., M.C.d.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Halim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn C.H.","family":"van den Oord","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Rijnstate Hospital, Arnhem, The Netherlands (S.C.H.v.d.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Arkenbout","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tergooi Medical Center, Hilversum, The Netherlands (K.A.)."},{"name":"Department of Cardiology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands (K.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-2217","authenticated-orcid":true,"given":"Marlies M.","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical Spectrum Twente, Enschede, The Netherlands (M.M.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5870-9923","authenticated-orcid":true,"given":"Pier","family":"Woudstra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Frisius Medical Center, Leeuwarden, The Netherlands (P.W., T.N.E.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-2429","authenticated-orcid":true,"given":"Tessel N.E.","family":"Vossenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Frisius Medical Center, Leeuwarden, The Netherlands (P.W., T.N.E.V.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1005-7293","authenticated-orcid":true,"given":"Nick D.","family":"Fagel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Noordwest Hospital Group, Alkmaar, The Netherlands (N.D.F., T.A.C.M.H., J.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton A.C.M.","family":"Heestermans","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Noordwest Hospital Group, Alkmaar, The Netherlands (N.D.F., T.A.C.M.H., J.H.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1006-2112","authenticated-orcid":true,"given":"Jan H.","family":"Cornel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands (F.W.A., C.C., T.P.J.J., B.Y., J.H.C., N.v.R., 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Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.125.016450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T18:00:52Z","timestamp":1782064852000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.125.016450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.125.016450"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.125.016450","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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