{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:42:54Z","timestamp":1791492174880,"version":"4.3.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Drug-coated balloons (DCBs) are increasingly adopted in percutaneous coronary intervention. Bail-out drug-eluting stent (DES) implantation due to suboptimal immediate results after DCB angioplasty is not infrequent, and the clinical outcomes of percutaneous coronary intervention with DCB angioplasty followed by bail-out DES implantation remain unexplored. The aim of this study was to evaluate the safety of bail-out DES implantation following DCB angioplasty in percutaneous coronary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The BAILOUT registry included consecutive patients undergoing bail-out DES implantation after DCB angioplasty at 17 European centers between 2011 and 2024. The primary end point was target lesion failure (TLF) at 1 year, defined as the composite of target lesion revascularization, target vessel myocardial infarction, and cardiac death. The TLF rate was compared with a performance goal of 7.0% for an upfront DES-only strategy, derived from a meta-analysis of contemporary randomized controlled trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 733 patients were included, accounting for 5.5% of all DCB-based percutaneous coronary interventions. At 1 year, the cumulative TLF incidence in the overall population was 7.0% (95% CI, 5.2%\u20139.3%), which was comparable to the performance goal (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.916). This was mainly driven by target lesion revascularization (4.1%), while cardiac death and target vessel myocardial infarction occurred both in 1.9% of patients. The incidence of stent thrombosis was 0.6%. Independent predictors of 1-year TLF included lesion length (hazard ratio, 1.02 per mm increase [95% CI, 1.01\u20131.03];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), moderate-to-severe calcification (hazard ratio, 2.82 [95% CI, 1.48\u20135.40];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.002), and the use of paclitaxel- versus sirolimus-coated balloons (hazard ratio, 1.99 [95% CI, 1.01\u20134.05];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.048).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In cases of suboptimal angiographic results after DCB angioplasty, bail-out DES implantation is safe, with no increased risk of TLF at 1 year compared with the expected performance goal for an upfront DES-only strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.125.016461","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:00:35Z","timestamp":1777539635000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Outcomes of Bail-Out Stenting After Drug-Coated Balloon Angioplasty: The International Multicenter BAILOUT Registry"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-3860","authenticated-orcid":true,"given":"Mauro","family":"Gitto","sequence":"first","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy (M. Gitto, G.C., F.T., M.C., D.R., A.M., G.G., B.R., G.G.S., A.C.)."},{"name":"Department of Biomedical Sciences; Humanitas University; Pieve Emanuele-Milan, Italy (M. Gitto, G.C., F.T., M.C., G.G.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-4760","authenticated-orcid":true,"given":"Pier Pasquale","family":"Leone","sequence":"additional","affiliation":[{"name":"Montefiore Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (P.P.L., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-2282","authenticated-orcid":true,"given":"Tuomas T.","family":"Rissanen","sequence":"additional","affiliation":[{"name":"Heart Center, Central Hospital of North Karelia, Joensuu, and the University of Eastern Finland (T.T.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6837-5787","authenticated-orcid":true,"given":"Natasha","family":"Corballis","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital, United Kingdom (N.C., I.M., V.S.V., S.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianmaria","family":"Calamita","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy (M. 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