{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:39:53Z","timestamp":1792521593657,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n BACKGROUND:<\/jats:title>\n Studies on mitral transcatheter edge-to-edge repair for atrial functional mitral regurgitation (AFMR) and ventricular functional mitral regurgitation (VFMR) are limited.<\/jats:p>\n <\/jats:sec>\n \n METHODS:<\/jats:title>\n We report 1-year outcomes of mitral transcatheter edge-to-edge repair for AFMR and VFMR using the PASCAL transcatheter valve repair system in the MiCLASP (Transcatheter Repair of Mitral Regurgitation With Edwards Pascal Transcatheter Valve Repair System) multicenter European postmarket clinical follow-up study.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n Analysis included 295 patients with FMR (75.5\u00b19.93 years old, 59.3% male) from the first 600 enrolled in the MiCLASP study, with AFMR in 17.6% (52) and VFMR in 82.4% (243). Patients with AFMR were older (79.7\u00b16.67 versus 74.6\u00b110.30 years), majority female (75.0% versus 33.3%), and had higher rates of hypertension (98.1% versus 82.3%) and atrial fibrillation (82.7% versus 60.1%) than patients with VFMR (all\n P<\/jats:italic>\n <0.05). Patients with VFMR had higher NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels (3350 [1720\u20136564] versus 1562 [790\u20132286];\n P<\/jats:italic>\n <0.001) and more severe mitral regurgitation (\u22653+) at baseline (71.9% versus 46.2%;\n P<\/jats:italic>\n <0.001). Procedural success was high (AFMR, 96.2%; VFMR, 97.1%;\n P<\/jats:italic>\n =0.661), and patients with AFMR had shorter procedure duration (73.5 versus 85.5 minutes;\n P<\/jats:italic>\n =0.044). One-year Kaplan-Meier estimate of freedom from all-cause mortality or heart failure hospitalization was 79.3% in AFMR and 70.9% in VFMR (\n P<\/jats:italic>\n =0.267). Both AFMR and VFMR groups demonstrated significant mitral regurgitation reduction (mitral regurgitation \u22641+, 93.1% and 81.3%), low mean transmitral gradients (3.5 and 3.1 mm\u2009Hg), significant proportional reductions in left ventricular end-diastolic volume (\u221212.9% and \u221216.4%) and left atrial volume (\u22129.6% and \u221210.9%), high proportions at New York Heart Association class I\/II (76.5% and 64.6%), and significant increases in Kansas City Cardiomyopathy Questionnaire Overall Summary score (+18.0 and +11.6 points), respectively (all\n P<\/jats:italic>\n <0.05 from baseline).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n One-year MiCLASP results support the safety of mitral transcatheter edge-to-edge repair with the PASCAL system in both AFMR and VFMR, with comparable echocardiographic, functional, and quality-of-life changes, despite baseline differences in clinical presentation.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION:<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n ; Unique identifier: NCT04430075.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/circinterventions.126.016563","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T09:00:28Z","timestamp":1787648428000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["One-Year Outcomes of M-TEER With the PASCAL System in Atrial and Ventricular FMR: Insights From the MiCLASP Postmarket Clinical Follow-Up Study"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2336-7991","authenticated-orcid":true,"given":"Amir A.","family":"Mahabadi","sequence":"first","affiliation":[{"name":"West German Heart and Vascular Center, Clinic of Cardiology and Vascular Medicine, University Hospital Essen, University of Duisburg-Essen, Germany (A.A.M., T.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienush","family":"Rassaf","sequence":"additional","affiliation":[{"name":"West German Heart and Vascular Center, Clinic of Cardiology and Vascular Medicine, University Hospital Essen, University of Duisburg-Essen, Germany (A.A.M., T.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2571-5024","authenticated-orcid":true,"given":"Tobias","family":"Kister","sequence":"additional","affiliation":[{"name":"Universit\u00e4t Leipzig, Germany (T.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Contilia Herz- und Gef\u00e4\u00dfzentrum, Elisabeth-Krankenhaus Essen, Germany (T.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8864-6038","authenticated-orcid":true,"given":"Tobias","family":"Geisler","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum T\u00fcbingen, Germany (T.G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Kath. Marienkrankenhaus Hamburg gGmbH, Germany (E.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2909-7961","authenticated-orcid":true,"given":"J\u00f6rg","family":"Hausleiter","sequence":"additional","affiliation":[{"name":"Medizinische Klinik und Poliklinik I, LMU Klinikum, Munich, Germany (J.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-246X","authenticated-orcid":true,"given":"Ingo","family":"Eitel","sequence":"additional","affiliation":[{"name":"Universitaetsklinikum Schleswig Holstein, L\u00fcbeck, Germany (I.E.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-0037","authenticated-orcid":true,"given":"Ralph Stephen","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"University medicine at the Johannes Gutenberg University in Mainz, Germany (R.S.v.B., P.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5244-0556","authenticated-orcid":true,"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[{"name":"Fondazione Toscana Gabriele Monasterio, Pisa, Italy (S. Berti)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0173-3903","authenticated-orcid":true,"given":"Axel","family":"Linke","sequence":"additional","affiliation":[{"name":"Herzzentrum Dresden, Universit\u00e4tsklinik an der Technischen Universit\u00e4t Dresden, Germany (A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-2994","authenticated-orcid":true,"given":"Christian","family":"Hengstenberg","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4t Wien\/AKH Wien, Vienna, Austria (C.H.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-6839","authenticated-orcid":true,"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinik der Ruhr-Universit\u00e4t Bochum-Bad Oeynhausen, Germany (V.R.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9889-1264","authenticated-orcid":true,"given":"Bernhard","family":"Uns\u00f6ld","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Giessen, Germany (B.U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-0203","authenticated-orcid":true,"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele, Milan, Italy (P.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8259-1737","authenticated-orcid":true,"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Herzzentrum der UniKlinik K\u00f6ln, Cologne, Germany (S. 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