{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:29:10Z","timestamp":1787077750424,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>AGENT is the only coronary drug-coated balloon (DCB) approved for treatment of in-stent restenosis (ISR) in the United States to date. In this study, we describe trends in DCB use and compare characteristics and in-hospital outcomes between patients who received DCB versus alternative treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We included patients in the American College of Cardiology National Cardiovascular Disease Registry CathPCI Registry who underwent percutaneous coronary intervention between April 2024 and June 2025 and received DCB, drug-eluting stent (DES), or plain old balloon angioplasty. Treatment groups were compared using standard mean differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Between April 2024 and June 2025, 14\u2009946 DCBs were used in 12\u2009337 patients across 704 CathPCI Registry sites. The monthly rate of DCB use for ISR percutaneous coronary intervention grew from &lt;1% to 17.5% during the study period. Of 96\u2009452 ISR procedures performed overall, 9269 (9.61%) involved the use of DCB. DCB procedures were more likely to involve the use of specialty balloons (DCB 45.3% versus DES 17.5% versus plain old balloon angioplasty 28.3%), intravascular imaging (DCB 54.5% versus DES 35.1% versus plain old balloon angioplasty 30.9%), and atherectomy (DCB 14.9% versus DES 6.0% versus plain old balloon angioplasty 7.3%). Among patients treated with DCB, 0.4% experienced myocardial infarction, 0.7% developed cardiogenic shock, 0.2% had an ischemic stroke, and 0.9% died. DCB was separately used in 3459 of 810\u2009483 (0.43%) non-ISR percutaneous coronary interventions. Unadjusted rates of in-hospital adverse outcomes after ISR and non-ISR DCB use were like those for DES (standard mean difference &lt;10%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Real-world DCB use is increasing rapidly in the United States, driven by use in ISR lesions but also with growth among non-ISR lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.126.016625","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:00:23Z","timestamp":1778576423000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Use of Paclitaxel-Coated Balloons in the United States: Early Results From the AGENT Postapproval Study"],"prefix":"10.1161","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7340-8111","authenticated-orcid":true,"given":"Christina","family":"Lalani","sequence":"first","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA (C.L., E.S., R.W.Y.)."},{"name":"Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.L., E.S., Y.S., H.D., R.W.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3861-3163","authenticated-orcid":true,"given":"Eric A.","family":"Secemsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA (C.L., E.S., R.W.Y.)."},{"name":"Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.L., E.S., Y.S., H.D., R.W.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8052-8395","authenticated-orcid":true,"given":"Yang","family":"Song","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.L., E.S., Y.S., H.D., R.W.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaying","family":"Dong","sequence":"additional","affiliation":[{"name":"Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.L., E.S., Y.S., H.D., R.W.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0061-1058","authenticated-orcid":true,"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center\/New York-Presbyterian Hospital (A.J.K.)."},{"name":"Cardiovascular Research Foundation, New York, NY (A.J.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Neupane","sequence":"additional","affiliation":[{"name":"Banner University Medical Center, Phoenix, AZ (S.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-7955","authenticated-orcid":true,"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Foundation, OH (A.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-2430","authenticated-orcid":true,"given":"Matthew J.","family":"Price","sequence":"additional","affiliation":[{"name":"Scripps Clinic, La Jolla, CA (M.J.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5973-5162","authenticated-orcid":true,"given":"Rhian E.","family":"Davies","sequence":"additional","affiliation":[{"name":"WellSpan York Hospital, PA (R.D.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod D.","family":"Frizzell","sequence":"additional","affiliation":[{"name":"Christ Hospital, Cincinnati, OH (J.D.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1360-9216","authenticated-orcid":true,"given":"Kathleen E.","family":"Kearney","sequence":"additional","affiliation":[{"name":"University of Washington Medical Center, Seattle (K.E.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan G.","family":"Safirstein","sequence":"additional","affiliation":[{"name":"Morristown Medical Center, NJ (J.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2482-3197","authenticated-orcid":true,"given":"Ziad A.","family":"Ali","sequence":"additional","affiliation":[{"name":"St Francis Hospital, Roslyn, NY (Z.A.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Boston Scientific Corporation, MA (R.C.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-4468","authenticated-orcid":true,"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA (C.L., E.S., R.W.Y.)."},{"name":"Richard A. and Susan F. Smith Center for Outcomes Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.L., E.S., Y.S., H.D., R.W.Y.)."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.123.013302"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.4244"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf002"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz594"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf083"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.1361"},{"key":"e_1_3_3_9_2","volume-title":"AGENT paclitaxel-coated balloon catheter \u2013 P230035","author":"FDA","year":"2024","unstructured":"FDA. AGENT paclitaxel-coated balloon catheter \u2013 P230035. 2024; Accessed November 4, 2025. https:\/\/www.fda.gov\/medical-devices\/recently-approved-devices\/agent-paclitaxel-coated-balloon-catheter-p230035"},{"key":"e_1_3_3_10_2","unstructured":"CathPCI Registry. Accessed August 11 2024. https:\/\/cvquality.acc.org\/NCDR-Home\/registries\/hospital-registries\/cathpci-registry"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.045"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001038"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001309"},{"key":"e_1_3_3_14_2","volume-title":"AGENT IDE: DCB performance for in-stent restenosis lasts out to 2 years","year":"2025","unstructured":"AGENT IDE: DCB performance for in-stent restenosis lasts out to 2 years. 2025; Accessed November 5, 2025. TCTMD.comhttps:\/\/www.tctmd.com\/news\/agent-ide-dcb-performance-stent-restenosis-lasts-out-2-years"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1028007"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.07.049"}],"container-title":["Circulation: Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/CIRCINTERVENTIONS.126.016625","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T18:00:22Z","timestamp":1787076022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/CIRCINTERVENTIONS.126.016625"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1161\/CIRCINTERVENTIONS.126.016625"],"URL":"https:\/\/doi.org\/10.1161\/circinterventions.126.016625","relation":{},"ISSN":["1941-7640","1941-7632"],"issn-type":[{"value":"1941-7640","type":"print"},{"value":"1941-7632","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}