{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:27:38Z","timestamp":1789118858481,"version":"build-2803163510"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The presence of tricuspid regurgitation (TR) may affect prognosis in patients with primary mitral regurgitation. This study sought to investigate the impact of concomitant TR on clinical outcomes in patients with primary mitral regurgitation undergoing mitral transcatheter edge-to-edge repair (M-TEER).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The PRIME-MR registry (Outcomes of Patients Treated With Mitral Transcatheter Edge-to-edge Repair for Primary Mitral Regurgitation) included 3083 patients with severe primary mitral regurgitation undergoing M-TEER from 2008 to 2022 at 25 international sites. Only patients with successful M-TEER procedures (mitral regurgitation\u2264Moderate) were analyzed. The study population was stratified by baseline TR severity: TR\u2264Moderate (TR\u2264Mod) versus TR\u2265Severe (TR\u2265Sev). The primary end point was 2-year all-cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      A total of 2155 patients were analyzed: TR\u2265Sev (n=421 [20%]) versus TR\u2264Mod (n=1734 [80%]). Patients with TR\u2265Sev were more likely to be New York Heart Association III\/IV (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.003), have shorter 6-minute walk distance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), higher NT-proBNP (N-terminal pro-B-type natriuretic peptide;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), higher creatinine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), higher pulmonary artery pressures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), atrial fibrillation (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), and more diuretics (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) than those with TR\u2264Mod. At 2 years, patients with TR\u2265Sev had higher mortality (29.6% versus 19.6%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>log-rank<\/jats:sub>\n                      &lt;0.0001) and heart failure hospitalization (21.1% versus 16.8%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>Gray<\/jats:sub>\n                      =0.018) than TR\u2264Mod. Baseline TR\u2265Sev was an independent predictor of 2-year mortality (adjusted hazard ratio, 2.01 [95% CI, 1.35\u20133.00];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). Although TR\u2265Sev decreased in 30% of patients after successful M-TEER, residual TR\u2265Sev was still associated with higher mortality (30.4% versus 19.9%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      <jats:sub>log-rank<\/jats:sub>\n                      =0.0037) than TR\u2264Mod.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In the PRIME-MR registry, 20% of patients with primary mitral regurgitation had severe TR at baseline. TR severity improved in 30% of TR\u2265Sev patients after successful M-TEER. The presence of TR\u2265Sev was independently associated with increased all-cause mortality at 2 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.126.016634","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:00:21Z","timestamp":1789117221000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Tricuspid Regurgitation on Outcomes After Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation: The PRIME-MR Registry"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-4384","authenticated-orcid":true,"given":"Andrea","family":"Scotti","sequence":"first","affiliation":[{"name":"Interventional Cardiology, Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (A.S., D.F., A.A.A., A.L.)."},{"name":"Interventional Cardiology, White Plains Hospital, NY (A.S., A.L.)."},{"name":"Department of Cardiology, Hospital Universitario de Salamanca, CIBERCV, IBSAL, Spain (A.S., I.C.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5752-4951","authenticated-orcid":true,"given":"Sebastian","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany (S.L., B.K., J.W., A.H., D.K.)."},{"name":"DZHK, German Center for Cardiovascular Research, Partner Site Hamburg\/Kiel\/L\u00fcbeck, Germany (S.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Feldman","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (A.S., D.F., A.A.A., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3607-2977","authenticated-orcid":true,"given":"Benedikt","family":"Koell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany (S.L., B.K., J.W., A.H., D.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2414-8766","authenticated-orcid":true,"given":"Jessica","family":"Weimann","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart &amp; Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Germany (S.L., B.K., J.W., A.H., D.K.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4548-3897","authenticated-orcid":true,"given":"Philipp","family":"von Stein","sequence":"additional","affiliation":[{"name":"Department III of Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany (P.v.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6038-4411","authenticated-orcid":true,"given":"Alejandro","family":"Araujo Adams","sequence":"additional","affiliation":[{"name":"Interventional Cardiology, Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY (A.S., D.F., A.A.A., A.L.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Heinze","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart &amp; 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