{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:29:38Z","timestamp":1787574578615,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["Circ: Cardiovascular Interventions"],"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve replacement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We analyzed data from an international, multicenter registry including consecutive patients undergoing transcatheter aortic valve replacement at 13 centers. The primary outcome was BVF according to Valve Academic Research Consortium-3 criteria. The cumulative incidence of BVF was estimated using a competing-risk approach. The association between BVF and clinical outcomes was assessed using competing-risk models with BVF as a time-dependent covariate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 7501 patients, BVF occurred in 380 (5.1%) patients over a median follow-up of 4 (interquartile range, 2\u20135) years. The cumulative incidence of BVF increased over time, reaching 1.4% at 1 year, 4.6% at 5 years, and 8.3% at 10 years. Independent predictors of BVF included younger age, smoking, balloon-expandable valve, prosthesis size &lt;26 mm, valve-in-valve procedure, mean gradient at discharge \u226515 mm\u2009Hg, moderate or severe aortic regurgitation at discharge, and early hemodynamic valve deterioration. BVF was independently associated with an increased risk of all-cause mortality (adjusted hazard ratio, 1.72 [95% CI, 1.47\u20132.01];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), cardiovascular mortality (adjusted hazard ratio, 3.23 [95% CI, 2.73\u20133.82];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001), stroke (adjusted hazard ratio, 2.08 [95% CI, 1.02\u20134.23];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.043), and heart failure hospitalization (adjusted hazard ratio, 1.43 [95% CI, 1.03\u20131.98];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.032). Consistent findings were observed in different sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>BVF is a clinically relevant event associated with adverse long-term outcomes. These findings support the implementation of tailored surveillance and preventive strategies to mitigate BVF-related risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/circinterventions.126.016892","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:07:49Z","timestamp":1787573269000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-4220","authenticated-orcid":true,"given":"Antonin","family":"Trimaille","sequence":"first","affiliation":[{"name":"Quebec Heart &amp; Lung Institute, Laval University, Canada (A.T., P.C.-G., M.A., J.R.-C.)."},{"name":"Department of Cardiovascular Medicine, Nouvel H\u00f4pital Civil Strasbourg University Hospital, France (A.T., A.C., O.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-7039","authenticated-orcid":true,"given":"Pedro","family":"Cepas-Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Quebec Heart &amp; Lung Institute, Laval University, Canada (A.T., P.C.-G., M.A., J.R.-C.)."},{"name":"Cardiology Department, Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic, Institut d\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain (P.C.-G., A.R., E.F.-U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4150-290X","authenticated-orcid":true,"given":"Marina","family":"Urena","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bichat\u2013Claude Bernard Hospital, Assistance Publique-H\u00f4pitaux de Paris, France (M.U., Q.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9939-8949","authenticated-orcid":true,"given":"Alberto","family":"Alperi","sequence":"additional","affiliation":[{"name":"\u00c1rea del Coraz\u00f3n. Hospital Universitario Central de Asturias, Oviedo, Spain (A.A., P.A.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, Oviedo, Spain (A.A., P.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-3820","authenticated-orcid":true,"given":"Gabriela","family":"Veiga-Fernandez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain (G.V.-F., V.F.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-8907","authenticated-orcid":true,"given":"Luis","family":"Nombela-Franco","sequence":"additional","affiliation":[{"name":"Cardiology Department, Instituto Cardiovascular, Hospital Clinico San Carlos, IdISSC, Madrid, Spain (L.N.-F., I.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-5963","authenticated-orcid":true,"given":"Victoria","family":"Vilalta","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Germans Trias i Pujol, Badalona, Spain (V.V., M. Trichilo)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8276-7325","authenticated-orcid":true,"given":"Maria","family":"del Trigo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Puerta de Hierro, Madrid, Spain (M. del Trigo, J.F.O.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio J.","family":"Mu\u00f1oz-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Virgen de la Victoria, Malaga, Spain (A.J.M.-G.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-7127","authenticated-orcid":true,"given":"Giovanni","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy (G.E., A.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-2120","authenticated-orcid":true,"given":"Vincent","family":"Auffret","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Rennes, Rennes University Hospital, France (V.A., M.N.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-5501","authenticated-orcid":true,"given":"David","family":"del Val","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de La Princesa, Madrid, Spain (D.V., F.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicen\u00e7","family":"Serra","sequence":"additional","affiliation":[{"name":"Cardiology Department, Vall d\u2019Hebron University Hospital, Barcelona, Spain (V.S., P.D.P.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8269-2244","authenticated-orcid":true,"given":"Jorge","family":"Nuche","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario 12 de Octubre, Instituto de Investigaci\u00f3n Sanitaria 12 de Octubre (imas12), Madrid, Spain (J.N., R.R.-S.)."},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica En Red de enfermedades CardioVasculares (CIBERCV), Madrid, Spain (J.N., R.R.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-5834","authenticated-orcid":true,"given":"Lluis","family":"Asmarats","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de la Santa Creu i Sant Pau, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain (L.A., D.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ander","family":"Regueiro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Institut Cl\u00ednic Cardiovascular, Hospital Cl\u00ednic, Institut d\u2019Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS), Barcelona, Spain (P.C.-G., A.R., E.F.-U.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3477-208X","authenticated-orcid":true,"given":"Adrien","family":"Carmona","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Nouvel H\u00f4pital Civil Strasbourg University Hospital, France (A.T., A.C., O.M.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-6868","authenticated-orcid":true,"given":"Quentin","family":"Fisher","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bichat\u2013Claude Bernard Hospital, Assistance Publique-H\u00f4pitaux de Paris, France (M.U., Q.F.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-6108","authenticated-orcid":true,"given":"Pablo","family":"Avanzas","sequence":"additional","affiliation":[{"name":"\u00c1rea del Coraz\u00f3n. Hospital Universitario Central de Asturias, Oviedo, Spain (A.A., P.A.)."},{"name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias, ISPA, Oviedo, Spain (A.A., P.A.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4434-0264","authenticated-orcid":true,"given":"V\u00edctor","family":"Fradejas-Sastre","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, Santander, Spain (G.V.-F., V.F.-S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0297-9409","authenticated-orcid":true,"given":"Ivan","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Instituto Cardiovascular, Hospital Clinico San Carlos, IdISSC, Madrid, Spain (L.N.-F., I.S.)."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Trichilo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Germans Trias i Pujol, Badalona, Spain (V.V., M. 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